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US4892740A Expired / Lapsed US ⏱️ 0.0 years remaining

Orally administrable pharmaceutical preparation of improved flavoring characteristics

Assignee: Taisho Pharmaceutical Co Ltd
•
Filing: 1988-01-25
•
Granted: 1990-01-09
•
Expires: 2008-01-25
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Abstract

Abstract An orally administrable pharmaceutical preparation of improved flavoring characteristics composed of a core material containing a drug and a coated layer applied to its surface, said coated layer being composed of a particulate polymeric substance having an average particle diameter of not more than 60 microns and being soluble in gastric juice; and a process for producing said orally administrable pharmaceutical preparation, which comprises causing minute liquid droplets of a volatile liquid containing a drug and optionally a gastric juice-soluble polymeric substance to fall onto a powder bed composed of a gastric juice-soluble particulate polymeric substance having an average particle diameter of not more than 60 microns to coat the surface of the liquid droplets with the gastric juice-soluble particulate polymeric substance, and drying the coated particles.

Inventors

  • 👤 Yasuji Takasima
  • 👤 Ikuo Koyama
  • 👤 Kimihide Shimano
  • 👤 Kaoru Maezuru

Bibliographic Details

Application Number —
Jurisdiction US
Data Source google_patents
Last Synchronized 2026-11-01 03:41
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/14; A61K9/16; A61K9/1605; A61K9/1629; A61K9/1635; A61K9/48; A61K9/50; A61K9/5005; A61K9/5021; A61K9/5026; A61K9/5089

Claims Analysis

Total Claims: 9
Claim 1
Independent Claim 52 words
An orally administrable pharmaceutical preparation of improved flavoring characteristics composed of a core material containing a drug and a coating layer applied to its surface, said coating layer being composed of a particulate polymeric substance having an average particle diameter of not more than 60 microns and being soluble in gastric juice.
Claim 2
Dependent Claim 52 words
An orally administrable pharmaceutical preparation of improved flavoring characteristics composed of a core material containing a drug and a coating layer applied to its surface, said coating layer being composed of a particulate polymeric substance having an average particle diameter of not more than 60 microns and being soluble in gastric juice.
Claim 3
Dependent Claim 21 words
The pharmaceutical preparation of claim 1 wherein said gastric juice-soluble polymeric substance is polyvinyl acetal diethylaminoacetate or dimethylaminoethyl methacrylate/methacrylic acid copolymer.
Claim 4
Dependent Claim 22 words
The pharmaceutical preparation of claim 1 wherein said gastric juice-soluble polymeric substance has an average particle diameter of 5 to 20 microns.
Claim 5
Dependent Claim 30 words
The pharmaceutical preparation of claim 1 which has an average particle diameter of at least 10 times as large as the average particle diameter of said gastric juice-soluble polymeric substance.
Claim 6
Dependent Claim 18 words
The pharmaceutical preparation of claim 4 which has an average particle diameter of not more than 600 microns.
Claim 7
Dependent Claim 12 words
A unit dosage form prepared from the pharmaceutical preparation of claim 1.
Claim 8
Dependent Claim 18 words
The unit dosage form of claim 6 which is a granule, pellet, capsule, pill, tablet, sugar-coated tablet or.
Claim 9
Dependent Claim 77 words
A process for producing the orally administrable pharmaceutical preparation of claim 1, which comprises causing minute liquid droplets of a volatile liquid containing a drug and optionally a gastric juice-soluble polymeric substance to fall onto a powder bed composed of a gastric juice-soluble particulate polymeric substance having an average particle diameter of not more than 60 microns to coat the surface of the liquid droplets with the gastric juice-soluble particulate polymeric substance, and drying the coated particles.

References Cited (Backward Citations)

US3202731A Cited
US3968277A Cited
US4150110A Cited
US4443497A Cited

USPTO Annuity & Maintenance Windows

Annuity Stage Window Opens Payment Deadline Surcharge Period Until Estimated Fee Status
3.5 Years (Year 4) 1993-01-08 1993-07-10 1994-01-09 $2000.00 Window Closed / Lapsed
7.5 Years (Year 8) 1997-01-08 1997-07-10 1998-01-09 $3760.00 Window Closed / Lapsed
11.5 Years (Year 12) 2001-01-08 2001-07-10 2002-01-09 $7700.00 Window Closed / Lapsed

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