Patent US4889850A successfully refreshed from Google Patents.
US4889850A
Expired / Lapsed
US
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Treatment of colic and teething
Assignee: Individual
•
Filing: 1988-12-28
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Granted: 1989-12-26
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Expires: 2008-12-28
Abstract
Abstract Teething and colic are alleviated in infants and toddlers by the administration of a combination of an antihistamine and a benzodiazepine having sedative hypnotic activity. An exemplary antihistamine is hydroxyzine pamoate, and an exemplary benzodiazepine is diazepam.
Inventors
- 👤 Carl R. Thornfeldt
- 👤 Robert E. Thornfeldt
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-08 14:26
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/33; A61K31/395; A61K31/55
Claims Analysis
Total Claims: 14
Claim 1
Independent Claim
273 words
A method for the treatment of a subject suffering from a condition selected from the group consisting of teething and colic, said method comprising administering to said subject a therapeutically effective amount of a composition comprising an ataractic and a benzodiazepine having sedative hypnotic activity; said ataractic having the formula ##STR6## wherein R 1 is a member selected from the group consisting of C 1 -C 6 alkyl, hydroxy-(C 1 -C 6 alkyl), hydroxy-(C 1 -C 6 alkoxy)-(C 1 -C 6 alkyl), phenyl-(C 1 -C 6 alkyl), and (C 1 -C 6 alkyl)-phenyl-(C 1 -C 6 alkyl); and R 2 and R 3 are members independently selected from the group consisting of a hydrogen atom, a halogen atom, and C 1 -C 6 alkyl; or an acid salt thereof; and said benzodiazepine having the formula ##STR7## wherein R 4 is a member selected from the group consisting of hydrogen, C 1 -C 6 alkyl, C 3 -C 6 cycloalkyl, C 1 -C 6 haloalkyl, amino-(C 1 -C 6 alkyl), (C 1 -C 3 alkylamino)-(C 1 -C 3 alkyl), and di-(C 1 -C 3 alkyl)-amino-(C 1 -C 6 alkyl); R 5 is a member selected from the group consisting of a hydrogen atom, hydroxy, and carboxy; R 6 is a member selected from the group consisting of a hydrogen atom, a halogen atom, and C 1 -C 6 alkyl; and R 7 is a member selected from the group consisting of a hydrogen atom, a halogen atom, and C 1 -C 6 alkyl; or a salt thereof; and the mole ratio of said ataractic to said benzodiazepine being from about 0.05 to about 2.0.
Claim 2
Independent Claim
273 words
A method for the treatment of a subject suffering from a condition selected from the group consisting of teething and colic, said method comprising administering to said subject a therapeutically effective amount of a composition comprising an ataractic and a benzodiazepine having sedative hypnotic activity; said ataractic having the formula ##STR6## wherein R 1 is a member selected from the group consisting of C 1 -C 6 alkyl, hydroxy-(C 1 -C 6 alkyl), hydroxy-(C 1 -C 6 alkoxy)-(C 1 -C 6 alkyl), phenyl-(C 1 -C 6 alkyl), and (C 1 -C 6 alkyl)-phenyl-(C 1 -C 6 alkyl); and R 2 and R 3 are members independently selected from the group consisting of a hydrogen atom, a halogen atom, and C 1 -C 6 alkyl; or an acid salt thereof; and said benzodiazepine having the formula ##STR7## wherein R 4 is a member selected from the group consisting of hydrogen, C 1 -C 6 alkyl, C 3 -C 6 cycloalkyl, C 1 -C 6 haloalkyl, amino-(C 1 -C 6 alkyl), (C 1 -C 3 alkylamino)-(C 1 -C 3 alkyl), and di-(C 1 -C 3 alkyl)-amino-(C 1 -C 6 alkyl); R 5 is a member selected from the group consisting of a hydrogen atom, hydroxy, and carboxy; R 6 is a member selected from the group consisting of a hydrogen atom, a halogen atom, and C 1 -C 6 alkyl; and R 7 is a member selected from the group consisting of a hydrogen atom, a halogen atom, and C 1 -C 6 alkyl; or a salt thereof; and the mole ratio of said ataractic to said benzodiazepine being from about 0.05 to about 2.0.
Claim 3
Dependent Claim
84 words
A method in accordance with claim 1 in which R 1 is a member selected from the group consisting of C 1 -C 3 alkyl, hydroxy-(C 1 -C 3 alkyl), hydroxy-(C 1 -C 3 alkoxy)-(C 1 -C 3 alkyl), phenyl-(C 1 -C 3 alkyl), and (C 1 -C 4 alkyl)-phenyl-(C 1 -C 3 alkyl); and R 2 and R 3 are members independently selected from the group consisting of a hydrogen atom, a chlorine atom, a bromine atom, and C 1 -C 3 alkyl.
Claim 4
Dependent Claim
78 words
A method in accordance with claim 1 in which R 1 is a member selected from the group consisting of methyl, hydroxyethoxyethyl, and (C 1 -C 4 alkyl)-phenylmethyl; R 2 is a member selected from the group consisting of a hydrogen atom, a chlorine atom and a bromine atom; R 3 is a hydrogen atom; and said acid salt is a member selected from the group consisting of a hydrochloride salt, a lactate salt and a pamoate salt.
Claim 5
Dependent Claim
31 words
A method in accordance with claim 1 in which R 1 is hydroxyethoxyethyl, R 2 is 4-chloro, R 3 is a hydrogen atom, and said compound is the pamoate salt thereof.
Claim 6
Dependent Claim
109 words
A method in accordance with claim 1 in which R 4 is a member selected from the group consisting of a hydrogen atom, C 1 -C 3 alkyl, cyclopropyl-(C 1 -C 3 alkyl), C 1 -C 3 alkyl substituted by 1 to 3 halogen atoms, and di-(C 1 -C 3 alkyl)-amino-(C 1 -C 3 alkyl); R 5 is a member selected from the group consisting of a hydrogen atom, hydroxy, and carboxy; R 6 is a member selected from the group consisting of a hydrogen atom and a halogen atom; and R 7 is a member selected from the group consisting of a hydrogen atom and a halogen atom.
Claim 7
Dependent Claim
70 words
A method in accordance with claim 1 in which R 4 is a member selected from the group consisting of a hydrogen atom, methyl, cyclopropylmethyl, 2,2,2-trifluoroethyl, and diethylaminoethyl; R 5 is a member selected from the group consisting of a hydrogen atom, hydroxy, and carboxy; R 6 is a member selected from the group consisting of a hydrogen atom and a chlorine atom; and R 7 is a chlorine atom.
Claim 8
Dependent Claim
32 words
A method in accordance with claim 1 in which R 4 is methyl, R 5 is a hydrogen atom, R 6 is a hydrogen atom, and R 7 is a chlorine atom.
Claim 9
Dependent Claim
40 words
A method in accordance with claim 1 in which said ataractic is a member selected from the group consisting of hydroxyzine hydrochloride and hydroxyzine pamoate, and said benzodiazepine is a member selected from the group consisting of diazepam and lorazepam.
Claim 10
Dependent Claim
18 words
A method in accordance with claim 1 in which said mole ratio is about 0.1 to about 1.0.
Claim 11
Dependent Claim
29 words
A method in accordance with claim 1 in which said ataractic is hydroxyzine pamoate and said benzodiazepine is diazepam, and said mole ratio is about 0.1 to about 1.0.
Claim 12
Dependent Claim
29 words
A method in accordance with claim 1 in which said ataractic is hydroxyzine pamoate and said benzodiazepine is diazepam, and said mole ratio is about 0.1 to about 0.5.
Claim 13
Dependent Claim
29 words
A method in accordance with claim 1 in which said ataractic is hydroxyzine pamoate and said benzodiazepine is lorazepam, and said mole ratios is about 0.1 to about 1.0.
Claim 14
Dependent Claim
29 words
A method in accordance with claim 1 in which said ataractic is hydroxyzine pamoate and said benzodiazepine is lorazepam, and said mole ratio is about 0.1 to about 0.5.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1992-12-25 | 1993-06-26 | 1993-12-26 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1996-12-25 | 1997-06-26 | 1997-12-26 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2000-12-25 | 2001-06-26 | 2001-12-26 | $7700.00 | Window Closed / Lapsed |