US4889720A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Sustained release dosage form for use with tissues of the oral cavity
Assignee: Teikoku Seiyaku Co Ltd
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Filing: 1987-08-31
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Granted: 1989-12-26
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Expires: 2007-08-31
Abstract
Abstract A drug reservoir containing an active substance such as a drug is formed on an adhesive layer which can adhere to an oral mucosal membrane. A polymer, which does not dissolve with saliva, is further coated on the drug reservoir as a drug release controlling layer to form an entire oral cavity sustained release dosage form. A drug impermeable layer can be formed between the adhesive layer and the drug reservoir.
Inventors
- 👤 Ryoji Konishi
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-28 16:39
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/0012; A61K9/0053; A61K9/006
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
82 words
A controlled release dosage form for application to oral cavity tissue, comprising: an adhesive layer having a first side adherable to oral cavity tissue; a reservoir containing an active substance positioned over a second side of the adhesive layer; and a controlled release layer covering the reservoir and providing for a delayed release of the active substance into the oral cavity wherein the first side of the adhesive layer adherable to oral cavity tissue is left uncovered by the controlled release layer.
Claim 2
Dependent Claim
82 words
A controlled release dosage form for application to oral cavity tissue, comprising: an adhesive layer having a first side adherable to oral cavity tissue; a reservoir containing an active substance positioned over a second side of the adhesive layer; and a controlled release layer covering the reservoir and providing for a delayed release of the active substance into the oral cavity wherein the first side of the adhesive layer adherable to oral cavity tissue is left uncovered by the controlled release layer.
Claim 3
Dependent Claim
57 words
A controlled release dosage form as claimed in claim 1, wherein said reservoir comprises a layer, and wherein said adhesive layer is positioned along one side of said reservoir layer, and said controlled release layer is positioned along both a side of said reservoir layer opposite said one side and along an edge of said reservoir layer.
Claim 4
Dependent Claim
26 words
A controlled release dosage form as claimed in claim 1, wherein said dosage form includes an impermeable layer positioned between said reservoir and said adhesive layer.
Claim 5
Dependent Claim
16 words
A controlled release dosage form as claimed in claim 1, wherein said dosage form is oval-shaped.
Claim 6
Dependent Claim
39 words
A controlled release dosage form as claimed in claim 4, wherein said oval-shaped dosage form has a shorter diameter of from about 3 to about 10 mm and a longer diameter of from about 5 to about 30 mm.
Claim 7
Dependent Claim
50 words
A controlled release dosage form as claimed in claim 1, wherein said controlled release layer comprises ethyl methacrylate-ethyl trimethylammonium chloride methacrylate copolymer, dimethylaminoethyl methacrylate - methylmethacrylate copolymer, 2-methyl-5-vinylpyridine-2-methacrylic acid - methacrylic acid copolymer, carboxymethylethyl cellulose, cellulose acetate - phthalate, polyvinylacetal diethylamino acetate, polyvinyl alcohol, vinyl acetate resin, cellac or gelatin.
Claim 8
Dependent Claim
32 words
A controlled release dosage form as claimed in claim 6, wherein said controlled release layer includes polyethylene glycol, propylene glycol, glycerin, 1,3-butane diol, glycerin-fatty acid ester, triacetin, or a citric acid ester.
Claim 9
Dependent Claim
24 words
A controlled release dosage form as claimed in claim 3 wherein said impermeable layer comprising ethylcellulose, cellulose acetate, or dimethylaminoethyl methacrylate - methylmethacrylate copolymer.
Claim 10
Dependent Claim
53 words
A controlled release dosage form as claimed in claim 1, wherein said adhesive layer includes at least one water-soluble polymer, a plasticizer and a water-insoluble or sparingly water-soluble compound, and wherein said adhesive layer exhibits adhesiveness to tissue of the oral cavity upon gradual dissolution or gelation of said adhesive layer with saliva.
Claim 11
Dependent Claim
63 words
A controlled release dosage form as claimed in claim 1, wherein said active substance comprises a benzodiazepine, a psychotherapeutic drug, an anti-ulcer drug, a spasmolytic, an antihistamine, a cardiotonic, an antiarrhymic drug, a diuretic, an antihypertensive, a vasoconstrictor, a vasodilator, a nitrous acid drug, a calcium antagonist, a hormone, a vitamin, an anti-smoking drug, an anti-cancer drug, an antibiotic, or a chemotherapeutic agent.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1992-12-25 | 1993-06-26 | 1993-12-26 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1996-12-25 | 1997-06-26 | 1997-12-26 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2000-12-25 | 2001-06-26 | 2001-12-26 | $7700.00 | Window Closed / Lapsed |