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US4888366A
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Inductive collagen-based bone repair preparations
Assignee: Collagen Aesthetics Inc
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Filing: 1987-09-25
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Granted: 1989-12-19
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Expires: 2007-09-25
Abstract
Abstract An improved process for the preparation of mineral/collagen/OF (osteogenic factor) inductive implants for bone repair utilizes drying, under ambient pressure conditions, a suspension of 75-95% mineral particles, 5-25% collagen, and an effective amount of OF, such as 0.5-4% partially purified OFE or its equivalent wherein the concentration of collagen in the suspension subjected to drying is 30-100 mg/ml. The resulting implants are improved. They are homogeneous in composition and have a high compressive modulus as well as containing OF in a biologically active and available form.
Inventors
- 👤 George Chu
- 👤 Ranga Nathan
- 👤 Saeid Seyedin
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 21:34
CPC Classifications
A; A61; A61L; A61L27/00; A61L27/14; A61L27/22; A61L27/227; A61L27/36; A61L27/3641; A61L27/3645; A61L27/365; A61L27/40; A61L27/44; A61L27/46; C; C07; C07K; C07K14/00; C07K14/435; C07K14/475; C07K14/51; A61K; A61K38/00; A61L2430/00; A61L2430/02; Y; Y10; Y10S; Y10S623/00; Y10S623/92; Y10S623/923
Claims Analysis
Total Claims: 22
Claim 1
Independent Claim
110 words
A process for preparing a hypoimmunogenic composition suitable for implantation to effect bone repair in a vertebrate wherein the composition comprises an osteoinductively effective amount of a protein osteoinductive factor (OF), which OF is sufficiently pure to be hypoimmunogenic in a xenogeneic host, and a carrier having components which consist essentially of mineral constituting 60-98% and collagen constituting 2-40% of the composition, which process comprises: (a) preparing a uniform suspension in water of the collagen, mineral, and OF components of the composition so that the concentration of collagen in the suspension is 30-100 mg/ml; and (b) subjecting the suspension to controlled drying under ambient pressure to obtain a rigid solid.
Claim 2
Dependent Claim
110 words
A process for preparing a hypoimmunogenic composition suitable for implantation to effect bone repair in a vertebrate wherein the composition comprises an osteoinductively effective amount of a protein osteoinductive factor (OF), which OF is sufficiently pure to be hypoimmunogenic in a xenogeneic host, and a carrier having components which consist essentially of mineral constituting 60-98% and collagen constituting 2-40% of the composition, which process comprises: (a) preparing a uniform suspension in water of the collagen, mineral, and OF components of the composition so that the concentration of collagen in the suspension is 30-100 mg/ml; and (b) subjecting the suspension to controlled drying under ambient pressure to obtain a rigid solid.
Claim 3
Dependent Claim
15 words
The process of claim 1 wherein the carrier is 75-95% mineral and 5-25% of collagen.
Claim 4
Dependent Claim
18 words
The process of claim 1 wherein the drying is conducted in air at a temperature of 1°-40° C.
Claim 5
Dependent Claim
18 words
The process of claim 1 wherein the drying is conducted in air at a temperature of 15°-37° C.
Claim 6
Dependent Claim
23 words
The process of claim 1 wherein the drying is continued until the solid has a compressive modulus of at least 20N/cm 2 .
Claim 7
Dependent Claim
15 words
The process of claim 1, which further includes heat curing of the product of (b).
Claim 8
Dependent Claim
24 words
The process of claim 6 wherein the heat curing is conducted until the solid has a compressive modulus of at least 50N/cm 2 .
Claim 9
Dependent Claim
17 words
The process of claim 6 wherein the heat curing is conducted at 50°-120° C. for 4-168 hours.
Claim 10
Dependent Claim
41 words
The process of claim 1 wherein the suspension of (a) is prepared by mixing a dilute solution of OF with mineral particles, drying the mixture, and mixing the dried mixture with reconstituted atelopeptide fibrillar collagen suspension containing 30-100 mg/ml of collagen.
Claim 11
Dependent Claim
21 words
The process of claim 9 wherein the mixture of the solution of OF and mineral particles is dried by air drying.
Claim 12
Dependent Claim
20 words
The process of claim 9 wherein the mixture of the solution of OF and mineral particles is dried by lyophilization.
Claim 13
Dependent Claim
46 words
The process of claim 1 wherein the suspension of (a) is prepared by adding a solution of OF to collagen in solution, precipitating the collagen and OF, resuspending the precipitate to a collagen concentration of 30-100 mg/ml, and then mixing the resulting suspension with mineral particles.
Claim 14
Dependent Claim
12 words
A bone repair composition prepared according to the process of claim 1.
Claim 15
Dependent Claim
12 words
A bone repair composition prepared according to the process of claim 2.
Claim 16
Dependent Claim
12 words
A bone repair composition prepared according to the process of claim 6.
Claim 17
Dependent Claim
68 words
A hypoimmunogenic composition suitable for implantation to effect bone repair in a vertebrate, which consists essentially of 60-98% mineral particles; 2-40% of atelopeptide hypoimmunogenic collagen; and an effective amount of an OF preparation, wherein the implant is a porous rigid solid of compressive modulus greater than 20N/cm 2 , is homogeneous with respect to its components, and wherein the OF is in a biologically active and available form.
Claim 18
Dependent Claim
68 words
A hypoimmunogenic composition suitable for implantation to effect bone repair in a vertebrate, which consists essentially of 60-98% mineral particles; 2-40% of atelopeptide hypoimmunogenic collagen; and an effective amount of an OF preparation, wherein the implant is a porous rigid solid of compressive modulus greater than 20N/cm 2 , is homogeneous with respect to its components, and wherein the OF is in a biologically active and available form.
Claim 19
Dependent Claim
14 words
The composition of claim 16 having a compressive modulus greater than 50N/cm 2 .
Claim 20
Dependent Claim
21 words
The composition of claim 16 wherein the effective amount of OF preparation is 0.5%-4% of partially purified OFE or its equivalent.
Claim 21
Dependent Claim
18 words
The composition of claim 18 wherein the effective amount of OF preparation is 0.5%-4% of partially purified OFE.
Claim 22
Dependent Claim
27 words
The composition of claim 16 wherein the composition consists essentially of 75-95% mineral particles; 5-25% of atelopeptide hypimmunogenic collagen; and an effective amount of an OF preparation.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1992-12-18 | 1993-06-19 | 1993-12-19 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1996-12-18 | 1997-06-19 | 1997-12-19 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2000-12-18 | 2001-06-19 | 2001-12-19 | $7700.00 | Window Closed / Lapsed |