US4885376A
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New types of organometallic reagents and catalysts for asymmetric synthesis
Assignee: Iowa State University Research Foundation Inc
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Filing: 1987-10-13
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Granted: 1989-12-05
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Expires: 2007-10-13
Abstract
Abstract New chiral catalysts for asymmetric synthesis reactions. The catalysts induce chirality in desired fashion in product molecules. The catalysts are rigid quadruped or triped ligands which provide a rigid asymmetric enantio-face at the active catalyst cite, thus inducing preparation of enantiomer molecules.
Inventors
- 👤 John G. Verkade
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 08:36
CPC Classifications
C; C07; C07F; C07F15/00; C07F15/04; C07F15/045; B; B01; B01J; B01J31/00; B01J31/16; B01J31/24; B01J31/2404; B01J31/2409; C07C; C07C45/00; C07C45/49; C07C45/50; C07C45/505; C07F15/0006; C07F15/006; C07F15/0066; C07F15/0073; C07F15/008; C07F15/0086; C07F15/0093; C07F7/00; C07F7/003; C07F9/00; C07F9/02; C07F9/28; C07F9/50; C07F9/5022; B01J2231/00; B01J2231/20; B01J2231/30; B01J2231/32; B01J2231/323; B01J2231/40; B01J2231/44; B01J2531/00; B01J2531/02; B01J2531/0238; B01J2531/0258; B01J2531/40; B01J2531/80; B01J2531/82; B01J2531/822; B01J2531/824; B01J2531/84; B01J2531/847
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
115 words
Chiral catalysts having quadriped ligands for induction of chirality in reaction product molecules, said catalysts having the formula: ##STR6## wherein M is a transition metal selected from the group consisting of palladium, rhodium, platinum, nickel, titanium, zirconium and hafnium, E, E', E", and E'" corners are selected from the group consisting of organo electron donor moieties of phosphorus, nitrogen, arsenic, oxygen, sulfur, wherein y is from about 1 to about 3, x is from 0 to about 4, R and R' are selected from the group consisting of hydrogen, C 1 to C 10 alkyl, phenyl, and ring systems wherein R and R' are (CH 2 ) z and z is from 1 to 4.
Claim 2
Dependent Claim
115 words
Chiral catalysts having quadriped ligands for induction of chirality in reaction product molecules, said catalysts having the formula: ##STR6## wherein M is a transition metal selected from the group consisting of palladium, rhodium, platinum, nickel, titanium, zirconium and hafnium, E, E', E", and E'" corners are selected from the group consisting of organo electron donor moieties of phosphorus, nitrogen, arsenic, oxygen, sulfur, wherein y is from about 1 to about 3, x is from 0 to about 4, R and R' are selected from the group consisting of hydrogen, C 1 to C 10 alkyl, phenyl, and ring systems wherein R and R' are (CH 2 ) z and z is from 1 to 4.
Claim 3
Dependent Claim
17 words
The catalysts of claim 1 wherein E, E'and E" are the same and all different from E'".
Claim 4
Dependent Claim
26 words
The catalysts of claim 1 wherein E and E"' are the same and E' and E" are different from each other and from E and E'".
Claim 5
Dependent Claim
15 words
The catalysts of claim 1 wherein each of E, E', E" and E'" are different.
Claim 6
Dependent Claim
117 words
Chiral catalysts having triped ligands for induction of asymmetry into reacton product molecules yielded from reactions catalyzed by said catalysts, said catalysts having the formula: ##STR7## wherein M is a transition metal selected from the group consisting of palladium, rhodium, platinum, nickel, titanium, zirconium and hafnium, E, E', and E" are selected from the group consisting of electron donor moieties of phosphorus, nitrogen, arsenic, oxygen, sulfur, and R and R' are selected from the group consisting of hydrogen,, C 1 to C 10 alkyl, phenyl and ring systems wherein R and R' are (CH 2 ) z and z is from 1 to 4, and R"' is a hydrogen, aryl or C 1 to C 10 alkyl.
Claim 7
Dependent Claim
117 words
Chiral catalysts having triped ligands for induction of asymmetry into reacton product molecules yielded from reactions catalyzed by said catalysts, said catalysts having the formula: ##STR7## wherein M is a transition metal selected from the group consisting of palladium, rhodium, platinum, nickel, titanium, zirconium and hafnium, E, E', and E" are selected from the group consisting of electron donor moieties of phosphorus, nitrogen, arsenic, oxygen, sulfur, and R and R' are selected from the group consisting of hydrogen,, C 1 to C 10 alkyl, phenyl and ring systems wherein R and R' are (CH 2 ) z and z is from 1 to 4, and R"' is a hydrogen, aryl or C 1 to C 10 alkyl.
Claim 8
Dependent Claim
18 words
The catalyst of claim 5 wherein each of E 1 , E' and E" are all the same.
Claim 9
Dependent Claim
19 words
The catalyst of claim 5 wherein each of E and E' are the same and both different from E".
Claim 10
Dependent Claim
13 words
The catalyst of claim 5 wherein E, E' and E" are all different.
Claim 11
Dependent Claim
29 words
The catalyst of claim 1 wherein E, E', E" and E"' are diphenylphosphine, where "M" is palladium, "Y" is 1, "X" is 0, and R and R' are hydrogen.
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| 3.5 Years (Year 4) | 1992-12-04 | 1993-06-05 | 1993-12-05 | $2000.00 | Window Closed / Lapsed |
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