US4882144A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Solid, rapidly released medicament preparations containing dihydropyridines, and processes for their preparation
Assignee: Bayer AG
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Filing: 1986-05-19
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Granted: 1989-11-21
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Expires: 2006-05-19
Abstract
Abstract Solid dihydropyridines, e.g. nifedipine and nimodipine preparations having a maximum standard deviation of the active compound content of 3% contain 1 part by weight of nifedipine, 2 to 6 parts by weight of PVP with a mean molecular weight of 15,000 to 50,000, 3.5 to 15 parts by weight of cellulose, 0.25 to 4 parts by weight of starch and 0.5 to 4 parts by weight of cross-linked insoluble PVPP, and, if appropriate, one or more further pharmaceutical auxiliaries and excipients. These preparations show a good release of dihydropyridine with good content uniformity.
Inventors
- 👤 Ahmed Hegasy
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-05 13:22
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/33; A61K31/395; A61K31/435; A61K31/44; A61K9/00; A61K9/14; A61K9/141; A61K9/146; A61K9/16; A61K9/1605; A61K9/1629; A61K9/1652; A61K9/20; A61K9/2072; A61K9/2077
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
102 words
A solid, rapidly absorbable preparation in unit dosage form comprising 1 part by weight of a dihydropyridine as an active compound, 0.2 to 6.0 parts by weight of PVP having a mean molecular weight of 15,000 to 50,000, and a mixture of absorptive excipients comprising 3.5 to 15 parts by weight of cellulose, 0.25 to 4.0 parts by weight of starch, 0.25 to 4.0 parts by weight of crosslinked insoluble PVPP, said preparation provided by (a) coprecipitation of the dihydropyridine and the PVP, (b) granulation of the resultant coprecipitation without removal of the parent solution and (c) admixture with the adsorptive excipients.
Claim 2
Dependent Claim
102 words
A solid, rapidly absorbable preparation in unit dosage form comprising 1 part by weight of a dihydropyridine as an active compound, 0.2 to 6.0 parts by weight of PVP having a mean molecular weight of 15,000 to 50,000, and a mixture of absorptive excipients comprising 3.5 to 15 parts by weight of cellulose, 0.25 to 4.0 parts by weight of starch, 0.25 to 4.0 parts by weight of crosslinked insoluble PVPP, said preparation provided by (a) coprecipitation of the dihydropyridine and the PVP, (b) granulation of the resultant coprecipitation without removal of the parent solution and (c) admixture with the adsorptive excipients.
Claim 3
Dependent Claim
21 words
A solid, rapidly absorbable preparation according to claim 1 in the form of tablets, pills, dragees, granules, powders, capsules or sachets.
Claim 4
Dependent Claim
14 words
A solid rapidly absorbable preparation according to claim 1, wherein said dihydropyridine is nifedipine.
Claim 5
Dependent Claim
14 words
A solid, rapidly absorbable preparation according to claim 1, wherein said dihydropyridine is nimodipine.
Claim 6
Dependent Claim
25 words
A solid, rapidly absorbable preparation according to claim 1, wherein the active compound has a maximum relative standard deviation of 1.413% on a weight basis.
Claim 7
Dependent Claim
44 words
A solid, rapidly absorbable preparation according to claim 1, wherein the absorptive excipients comprise a mixture of 4 to 12 parts by weight of cellulose, 0.25 to 2.0 parts by weight of starch and 1 to 3 parts by weight of crosslinked insoluble PVPP.
Claim 8
Dependent Claim
28 words
A solid, rapidly absorbable preparation according to claim 1, wherein 50% of said dihydropyridine is released in less then 15 minutes as measured by the USP paddle method.
Claim 9
Dependent Claim
30 words
A solid, rapidly absorbable preparation according to claim 1, which further comprises one or more excipients selected from the group consisting of lactose, powdered sugar, mannitol, glycocoll and calcium carbonate.
References Cited (Backward Citations)
US4412986A
Cited
US4216155A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1992-11-20 | 1993-05-22 | 1993-11-21 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1996-11-20 | 1997-05-22 | 1997-11-21 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2000-11-20 | 2001-05-22 | 2001-11-21 | $7700.00 | Window Closed / Lapsed |