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US4216155A Expired / Lapsed US ⏱️ 0.0 years remaining

Process for the preparation of novel benzopyrane derivatives

Assignee: Novartis Corp
•
Filing: 1978-07-11
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Granted: 1980-08-05
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Expires: 1998-07-11
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Abstract

Abstract The present invention relates to novel benzopyrane derivatives, especially 3-oxaloamino-4-oxo-4H-1-benzopyrane derivatives of the formula I ##STR1## in which Ph is substituted or unsubstituted 1,2-phenylene, R is free, esterified or amidated carboxyl and R 1 is hydrogen or a substituted or substituted hydrocarbon radical, in the free form or in the form of a salt, exhibit antiallergic activities and are accordingly useful as active ingredients of antiallergic pharmaceutical preparations.

Inventors

  • 👤 Georges Haas
  • 👤 Alberto Rossi
  • 👤 Knut A. Jaeggi
  • 👤 Alex Sele

Bibliographic Details

Application Number —
Jurisdiction US
Data Source google_patents
Last Synchronized 2026-11-05 21:35
CPC Classifications
C; C07; C07D; C07D311/00; C07D311/02; C07D311/04; C07D311/22; C07D311/26; C07D311/28; C07D311/30; C07D311/94

Claims Analysis

Total Claims: 4
Claim 1
Independent Claim 164 words
A 3-glycoloylamino-4-oxo-4H-1-benzopyrane derivative of the formula I' ##STR9## wherein R is lower alkanoyloxy methyl, benzoyloxy methyl, benzoyloxy methyl mono- or di-substituted by lower alkyl, lower alkoxy or halogen, lower alkoxy-methyl, lower alkoxy-methyl mono- or di-substituted by hydroxyl, lower alkoxy or di-lower alkylamino, phenyl-lower alkoxy-methyl, phenyl-lower alkoxy-methyl mono- or di-substituted by lower alkyl, lower alkoxy or halogen; Ph is 1,2-phenylene which is unsubstituted or mono-substituted in one of the free positions by lower alkyl having not more than 4 carbon atoms, lower alkoxy having not more than 4 carbon atoms, lower alkanoyl having not more than 7 carbon atoms, hydroxyl or halogen with an atomic number of not more than 35 or is disubstituted on two adjacent free positions by 3-membered or 4-membered lower alkylene having not more than 4 carbon atoms or 3-membered or 4-membered lower alkylenedioxy, and R 1 is hydrogen, lower alkyl having not more than 4 carbon atoms or phenyl, in the free form or in the form of a salt.
Claim 2
Dependent Claim 164 words
A 3-glycoloylamino-4-oxo-4H-1-benzopyrane derivative of the formula I' ##STR9## wherein R is lower alkanoyloxy methyl, benzoyloxy methyl, benzoyloxy methyl mono- or di-substituted by lower alkyl, lower alkoxy or halogen, lower alkoxy-methyl, lower alkoxy-methyl mono- or di-substituted by hydroxyl, lower alkoxy or di-lower alkylamino, phenyl-lower alkoxy-methyl, phenyl-lower alkoxy-methyl mono- or di-substituted by lower alkyl, lower alkoxy or halogen; Ph is 1,2-phenylene which is unsubstituted or mono-substituted in one of the free positions by lower alkyl having not more than 4 carbon atoms, lower alkoxy having not more than 4 carbon atoms, lower alkanoyl having not more than 7 carbon atoms, hydroxyl or halogen with an atomic number of not more than 35 or is disubstituted on two adjacent free positions by 3-membered or 4-membered lower alkylene having not more than 4 carbon atoms or 3-membered or 4-membered lower alkylenedioxy, and R 1 is hydrogen, lower alkyl having not more than 4 carbon atoms or phenyl, in the free form or in the form of a salt.
Claim 3
Dependent Claim 9 words
A compound as claimed in claim 1 being 3-Glycoloylamino-4-oxo-4,6,7,8-tetrahydro-cyclopenta[g]-1-benzopyrane.
Claim 4
Dependent Claim 9 words
A compound as claimed in claim 1 being 3-Acetoxyglycoloylamino-4-oxo-4,6,7,8-tetrahydrocyclopenta[g]-1-benzopyrane.

References Cited (Backward Citations)

US3937719A Cited
US4076729A Cited

USPTO Annuity & Maintenance Windows

Annuity Stage Window Opens Payment Deadline Surcharge Period Until Estimated Fee Status
3.5 Years (Year 4) 1983-08-05 1984-02-04 1984-08-05 $2000.00 Window Closed / Lapsed
7.5 Years (Year 8) 1987-08-05 1988-02-04 1988-08-05 $3760.00 Window Closed / Lapsed
11.5 Years (Year 12) 1991-08-05 1992-02-04 1992-08-05 $7700.00 Window Closed / Lapsed

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