US4216155A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Process for the preparation of novel benzopyrane derivatives
Assignee: Novartis Corp
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Filing: 1978-07-11
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Granted: 1980-08-05
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Expires: 1998-07-11
Abstract
Abstract The present invention relates to novel benzopyrane derivatives, especially 3-oxaloamino-4-oxo-4H-1-benzopyrane derivatives of the formula I ##STR1## in which Ph is substituted or unsubstituted 1,2-phenylene, R is free, esterified or amidated carboxyl and R 1 is hydrogen or a substituted or substituted hydrocarbon radical, in the free form or in the form of a salt, exhibit antiallergic activities and are accordingly useful as active ingredients of antiallergic pharmaceutical preparations.
Inventors
- 👤 Georges Haas
- 👤 Alberto Rossi
- 👤 Knut A. Jaeggi
- 👤 Alex Sele
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-05 21:35
CPC Classifications
C; C07; C07D; C07D311/00; C07D311/02; C07D311/04; C07D311/22; C07D311/26; C07D311/28; C07D311/30; C07D311/94
Claims Analysis
Total Claims: 4
Claim 1
Independent Claim
164 words
A 3-glycoloylamino-4-oxo-4H-1-benzopyrane derivative of the formula I' ##STR9## wherein R is lower alkanoyloxy methyl, benzoyloxy methyl, benzoyloxy methyl mono- or di-substituted by lower alkyl, lower alkoxy or halogen, lower alkoxy-methyl, lower alkoxy-methyl mono- or di-substituted by hydroxyl, lower alkoxy or di-lower alkylamino, phenyl-lower alkoxy-methyl, phenyl-lower alkoxy-methyl mono- or di-substituted by lower alkyl, lower alkoxy or halogen; Ph is 1,2-phenylene which is unsubstituted or mono-substituted in one of the free positions by lower alkyl having not more than 4 carbon atoms, lower alkoxy having not more than 4 carbon atoms, lower alkanoyl having not more than 7 carbon atoms, hydroxyl or halogen with an atomic number of not more than 35 or is disubstituted on two adjacent free positions by 3-membered or 4-membered lower alkylene having not more than 4 carbon atoms or 3-membered or 4-membered lower alkylenedioxy, and R 1 is hydrogen, lower alkyl having not more than 4 carbon atoms or phenyl, in the free form or in the form of a salt.
Claim 2
Dependent Claim
164 words
A 3-glycoloylamino-4-oxo-4H-1-benzopyrane derivative of the formula I' ##STR9## wherein R is lower alkanoyloxy methyl, benzoyloxy methyl, benzoyloxy methyl mono- or di-substituted by lower alkyl, lower alkoxy or halogen, lower alkoxy-methyl, lower alkoxy-methyl mono- or di-substituted by hydroxyl, lower alkoxy or di-lower alkylamino, phenyl-lower alkoxy-methyl, phenyl-lower alkoxy-methyl mono- or di-substituted by lower alkyl, lower alkoxy or halogen; Ph is 1,2-phenylene which is unsubstituted or mono-substituted in one of the free positions by lower alkyl having not more than 4 carbon atoms, lower alkoxy having not more than 4 carbon atoms, lower alkanoyl having not more than 7 carbon atoms, hydroxyl or halogen with an atomic number of not more than 35 or is disubstituted on two adjacent free positions by 3-membered or 4-membered lower alkylene having not more than 4 carbon atoms or 3-membered or 4-membered lower alkylenedioxy, and R 1 is hydrogen, lower alkyl having not more than 4 carbon atoms or phenyl, in the free form or in the form of a salt.
Claim 3
Dependent Claim
9 words
A compound as claimed in claim 1 being 3-Glycoloylamino-4-oxo-4,6,7,8-tetrahydro-cyclopenta[g]-1-benzopyrane.
Claim 4
Dependent Claim
9 words
A compound as claimed in claim 1 being 3-Acetoxyglycoloylamino-4-oxo-4,6,7,8-tetrahydrocyclopenta[g]-1-benzopyrane.
References Cited (Backward Citations)
US3937719A
Cited
US4076729A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1983-08-05 | 1984-02-04 | 1984-08-05 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1987-08-05 | 1988-02-04 | 1988-08-05 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1991-08-05 | 1992-02-04 | 1992-08-05 | $7700.00 | Window Closed / Lapsed |