Apparatus and method for obtaining ultrasonic backcatter measurement from tissue

Claim 2

Apparatus for obtaining an optimal measurement of the absolute magnitude of the ultrasonic backscatter from a selected tissue region in a body of tissue, the tissue of the region forming distributed, unresolved ultrasonic reflectors, said apparatus being couplable to means for applying a transmitted ultrasonic signal to the body exteriorly thereof and for receiving a signal having spectral components of frequency at the exterior of the body, said received signal including the backscatter signal from the tissue region, said apparatus comprising: means for signal processing the backscatter signal form the region for compensating the backscatter signal for the frequency spectrum alterations contained in the backscatter signal resulting from the frequency response characteristics of the apparatus and the signal transmitting/receiving means, the bulk tissue loss, and the tissue of the region to provide an output in which each spectral component is equally weighted; and means coupled to said signal processing means for determining the power of the signal processing means output and providing an output of said power determining means being indicative of the absolute magnitude of the ultrasonic backscatter from the tissue of the region.

Claim 3

The apparatus according to claim 1 including bandpass means for limiting the frequency bandwidth of the signal processing means to a band of the received signal containing energy significant, relative to noise, for power determining purposes.

Claim 4

The apparatus according to claim 1 including scaling means for providing scaling to the output of said power determining means to provide the magnitude of the ultrasonic backscatter.

Claim 5

The apparatus according to claim 3 wherein said scaling means scales by a factor quantifying the indication of the magnitude of the backscatter in a desired manner.

Claim 6

The apparatus according to claim 1 including scaling means for providing scaling to the output of the power determining means by a factor quantifying the indication of the magnitude of the backscatter in a desired manner.

Claim 7

The apparatus according to claim 1 wherein the signal processing means is further defined as spectrally whitening the received signal to provide said compensation.

Claim 8

The apparatus according to claim 6 wherein the signal processing means is further defined as spectrally whitening the received signal for shape and scaling for spectral magnitude to provide said compensation.

Claim 9

The apparatus according to claim 6 wherein the frequency response characteristics of the tissue of the region are expressed by a power law and wherein said signal processing means spectrally whitens the received signal to compensate for such power law frequency response characteristics.

Claim 10

The apparatus according to claim 8 wherein the frequency response characteristics of the tissue of the region are expressed by a power law in which the intensity of the energy of the backscatter signal is proportional to the ultrasonic signal frequency raised by a power substantially equal to four and wherein said signal processing means spectrally whitens the received signal to compensate for such power law frequency response characteristics.

Claim 11

The apparatus according to claim 8 wherein the frequency response characteristics of the tissue of the region are expressed by a power law in which the magnitude of the energy of the backscatter signal is proportional to the ultrasonic signal frequency raised by a power substantially equal to two and wherein said signal processing means spectrally whitens the received signal to compensate for such power law frequency response characteristics.

Claim 12

The apparatus according to claim 6 wherein said signal processing means whitens the spectrum of the received signal for the frequency response effects of diffraction.

Claim 13

The apparatus according to claim 6 wherein said signal processing means whitens the spectrum of the received signal for the frequency response effects of transducer transfer function.

Claim 14

The apparatus according to claim 6 wherein said signal processing means whitens the spectrum of the received signal for the frequency response effects of the transmitted signal characteristics appearing in the received signal.

Claim 15

The apparatus according to claim 13 wherein said apparatus includes means for generating the transmitted signal and wherein said generating means generates a transmitted signal having frequency characteristics producing desired frequency effects in the received signal.

Claim 16

The apparatus according to claim 1 wherein the bulk tissue loss of the body attenuates the received signal and wherein said apparatus included range gain compensation means for overcoming the effects of the attenuation of the received signal.

Claim 17

The apparatus according to claim 1 wherein said power determining means includes means for squaring the output of said signal processing means.

Claim 18

The apparatus according to claim 16 wherein said output of said signal processing means includes outputs corresponding to a plurality of data points in said tissue region and said power determining means includes means coupled to said squaring means for providing an average of the squared outputs from data points of a contiguous portion of the tissue of the region.

Claim 19

The apparatus according to claim 17 wherein said average providing means includes means for summing the squared outputs form the contiguous tissue portion data points and for dividing the sum by the number of data points in the average.

Claim 20

The apparatus according to claim 1 further defined as obtaining the backscatter measurement from th tissue of an organ functioning in a cyclical manner, said apparatus including means for averaging measurements obtained over a plurality of functional cycles of the organ.

Claim 21

The apparatus according to claim 1 further defined as obtaining the backscatter measurement from the tissue of an organ functioning in a cyclical manner, said apparatus including means for averaging measurements obtained over the functional cycle of the organ.

Claim 22

The apparatus according to claim 1 further defined as obtaining the backscatter measurement from the tissue of an organ functioning in a cyclical manner, the magnitude of the backscatter varying during the functional cycle, said apparatus including means for determining the amplitude modulation characteristics of the varying backscatter signal.

Claim 23

The apparatus according to claim 1 further defined as obtaining the backscatter measurement from the tissue of an organ functioning in a cyclical manner, the magnitude of the backscatter signal cyclically varying during the functional cycle of the organ, said apparatus including means for determining the phase of the varying backscatter with respect to the functional cycle of the organ.

Claim 24

Apparatus for ultrasonically determining the physiological condition of myocardial tissue, said apparatus being couplable to means for applying a transmitted ultrasonic signal to the exterior of the thorax and for receiving a signal having spectral components of frequency at the exterior of the thorax, said received signal including the backscatter signal form the myocardial tissue, said apparatus comprising: signal processing means for spectrally whitening the backscatter signal from the myocardial tissue for compensating the backscatter signal for the frequency spectrum alterations contained in the backscatter signal resulting from the frequency response characteristics of the apparatus and the signal transmitting/receiving means, the bulk tissue loss, and the tissue of the myocardium to provide an output in which each spectral component is equally weighted, said output of said signal processing means including outputs corresponding to a plurality of data points in th myocardial tissue; bandpass means for limiting the frequency bandwidth of the signal processing means to a band containing energy significant, relative to noise, for power determining purposes; means for determining the power of the signal processing means output, said power determining means including means for squaring the output of said signal processing means, and means for providing an average of the squared data point outputs from a contiguous portion of the myocardial tissue as the output of said power determining means; scaling means for providing scaling to the output of the power determining means to provide an indication of the absolute magnitude of the ultrasonic backscatter from the myocardial tissue; and means for providing data indicative of the physiological condition of the myocardial tissue from the myocardial tissue ultrasonic backscatter magnitude.

Claim 25

Apparatus for ultrasonically determining the physiological condition of myocardial tissue, said apparatus being couplable to means for applying a transmitted ultrasonic signal to the exterior of the thorax and for receiving a signal having spectral components of frequency at the exterior of the thorax, said received signal including the backscatter signal form the myocardial tissue, said apparatus comprising: signal processing means for spectrally whitening the backscatter signal from the myocardial tissue for compensating the backscatter signal for the frequency spectrum alterations contained in the backscatter signal resulting from the frequency response characteristics of the apparatus and the signal transmitting/receiving means, the bulk tissue loss, and the tissue of the myocardium to provide an output in which each spectral component is equally weighted, said output of said signal processing means including outputs corresponding to a plurality of data points in th myocardial tissue; bandpass means for limiting the frequency bandwidth of the signal processing means to a band containing energy significant, relative to noise, for power determining purposes; means for determining the power of the signal processing means output, said power determining means including means for squaring the output of said signal processing means, and means for providing an average of the squared data point outputs from a contiguous portion of the myocardial tissue as the output of said power determining means; scaling means for providing scaling to the output of the power determining means to provide an indication of the absolute magnitude of the ultrasonic backscatter from the myocardial tissue; and means for providing data indicative of the physiological condition of the myocardial tissue from the myocardial tissue ultrasonic backscatter magnitude.

Claim 26

The apparatus according to claim 23 wherein said scaling means scales the output of the power determining mean by a factor quantifying the backscatter magnitude in a desired manner.

Claim 27

The apparatus according to claim 23 wherein the signal processing means is further defined as spectrally whitening the received signal for shape and scaling for spectral magnitude to provide said compensation.

Claim 28

The apparatus according to claim 23 wherein the frequency response characteristics of the myocardial tissue are expressed by a power law in which the intensity of the energy of the backscatter signal is proportional to the ultrasonic signal frequency raised by a power substantially equal to four and wherein said signal processing means spectrally whitens the received signal to compensate for such power law frequency response characteristics.

Claim 29

The apparatus according to claim 23 wherein said data providing means averages backscatter magnitudes obtained over a plurality of heart beats.

Claim 30

The apparatus according to claim 23 wherein said data providing means averages backscatter magnitudes obtained over a beat of the heart.

Claim 31

The apparatus according to claim 23 wherein said data providing means is further defined as determining the amplitude modulation characteristics of the backscatter magnitude.

Claim 32

The apparatus according to claim 23 wherein said data providing means is further defined as determining the phase of the backscatter signal magnitude with respect to the heart beat.

Claim 35

The method according to claim 31 including the step of limiting the frequency bandwidth of the signal being processed to a band containing energy significant, relative to noise, for power determining purposes.

Claim 36

The method according to claim 31 including the step of scaling to provide the magnitude of the ultrasonic backscatter in the further output.

Claim 37

The method according to claim 33 wherein the scaling step is further defined as scaling by a factor quantifying the indication of the magnitude of the backscatter in a desired manner.

Claim 38

The method according to claim 31 including the step of scaling by a factor quantifying the indication of the magnitude of the backscatter in a desired manner.

Claim 39

The method according to claim 31 wherein the signal processing step is further defined as spectrally whitening the received signal to provide said compensation.

Claim 40

The method according to claim 36 wherein the signal processing step is further defined as spectrally whitening the received signal for shape and scaling for spectral magnitude to provide said compensation.

Claim 41

The method according to claim 36 wherein the frequency response characteristics of the tissue region are expressed by a power law and wherein said signal processing step spectrally whitens the received signal to compensate for such power law frequency response characteristics.

Claim 42

The method according to claim 38 wherein the frequency response characteristics of the tissue of the region are expressed by a power law in which the intensity of the energy of the backscatter signal is proportional to the ultrasonic signal frequency raised by a power substantially equal to four and wherein said signal processing step spectrally whitens the received signal to compensate for such power law frequency response characteristics.

Claim 43

The method according to claim 38 wherein the frequency response characteristics of the tissue of the region are expressed by a power law in which the magnitude of the energy of the backscatter signal is proportional to the ultrasonic signal raised by a power substantially equal to two and wherein said signal processing step spectrally whitens the received signal to compensate for such power law frequency response characteristics.

Claim 44

The method according to claim 36 wherein said signal processing step whitens the spectrum of the received signal for the frequency response effects of diffraction.

Claim 45

The method according to claim 36 wherein said signal processing step whitens the spectrum of the received signal for the frequency response effects of transducer transfer function.

Claim 46

The method according to claim 36 wherein said signal processing step whitens the spectrum of the received signal for the frequency response effects of the transmitted signal characteristic appearing in the received signal.

Claim 47

The method according to claim 43 including the step of generating the transmitted signal with frequency characteristics producing desired frequency effects in the received signal.

Claim 48

The method according to claim 31 wherein the bulk tissue loss of the body attenuates the received signal and wherein the method includes the step of overcoming the effects of the attenuation of the received signal.

Claim 49

The method according to claim 31 wherein said power determining step includes the step of squaring the output of the signal processing step.

Claim 50

The method according to claim 46 wherein said output of said signal processing step includes outputs corresponding to a plurality of data points in said tissue of the region and said power determining step is further defined as providing an average of the squared outputs from data points of a contiguous portion of the tissue of the region.

Claim 51

The method according to claim 47 wherein said average providing step is further defined as summing the squared outputs from the contiguous tissue portion data points and dividing the sum by the number of data points in the average.

Claim 52

The method according to claim 31 further defined as obtaining the backscatter measurement from the tissue of an organ functioning in a cyclical manner, said method including the step of averaging measurements obtained over a plurality of functional cycles of the organ.

Claim 53

The method according to claim 31 further defined as obtaining the backscatter measurement from the tissue of an organ functioning in a cyclical manner, said method including the step of averaging measurements obtained over the functional cycle of the organ.

Claim 54

The method according to claim 31 further defined as obtaining the backscatter measurement from the tissue of an organ functioning in a cyclical manner, the magnitude of the backscatter varying during the functional cycle, said method including the step of determining the amplitude modulation characteristics of the varying backscatter signal.

Claim 55

The method according to claim 31 further defined as obtaining the backscatter measurement from the tissue of an organ functioning in a cyclicla manner, the magnitude of the backscatter signal cyclically varying during the functional cycle of the organ, said method including the step of determining the phase of the varying backscatter signal with respect to the functional cycle of the organ.

Claim 58

The method according to claim 53 including the step of scaling by a factor quantifying the backscatter magnitude in a desired manner.

Claim 59

The method according to claim 53 wherein the spectrally whitened step is further defined as spectrally whitening the received signal for shape and scaling for spectral magnitude to provide said compensation.

Claim 60

The method according to claim 53 wherein the frequency response characteristics of the myocardial tissue are expressed by a power law in which the intensity of the energy of the backscatter signal is proportional to the ultrasonic signal frequency raised by a power substantially equal to four and wherein said signal spectrally whitening spectrally whitens the received signal to compensate for such power law frequency response characteristics.

Claim 61

The method according to claim 53 wherein the data providing step is further defined as averaging measurements obtained over a plurality of heart beats.

Claim 62

The method according to claim 53 wherein the data providing step is further defined as averaging measurements obtained over a beat of the heart.

Claim 63

The method according to claim 53 wherein the data providing step is further defined as determining the amplitude modulation characteristics of the backscatter magnitude.

Claim 64

The method according to claim 53 wherein the data providing step is further defined as determining the phase of the backscatter magnitude with respect to the heart beat.