US4877774A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Administration of steroid hormones
Assignee: United States Department of Health and Human Services
•
Filing: 1987-09-09
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Granted: 1989-10-31
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Expires: 2007-09-09
Abstract
Abstract Crystalline complexes of steroid hormones with gamma-cyclodextrin are prepared by mixing the components together. Tablets can be formed from the complexes, which can be administered by contact with the mucosa to provide effective transfer of the hormones into the systemic circulation, gradually eliminating the hormones therefrom.
Inventors
- 👤 Josef Pitha
- 👤 Mitchell Harman
- 👤 Kaneto Uekama
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-04 14:22
CPC Classifications
A; A61; A61K; A61K47/00; A61K47/50; A61K47/69; A61K47/6949; A61K47/6951; A61K31/00; A61K31/56; A61K31/565; A61K31/57; B; B82; B82Y; B82Y5/00
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
44 words
A method for administering steroid hormones to a patient needing supplemental steroid hormones by direct contact with mucosa or the conjuctiva comprising contacting the mucosa of said patient needing supplemental steroid hormones with an effective amount of a steroid hormone complexed with crystalline gamma-cyclodextrin.
Claim 2
Independent Claim
44 words
A method for administering steroid hormones to a patient needing supplemental steroid hormones by direct contact with mucosa or the conjuctiva comprising contacting the mucosa of said patient needing supplemental steroid hormones with an effective amount of a steroid hormone complexed with crystalline gamma-cyclodextrin.
Claim 3
Dependent Claim
20 words
The method of claim 1 wherein the steroid hormones are selected from the group consisting of testosterone, estradiol, and progesterone.
Claim 4
Dependent Claim
11 words
The method of claim 2 wherein the steroid hormone is testosterone.
Claim 5
Independent Claim
39 words
A method of treating a mammal needing supplemental steroid hormones by administering steroid hormones comprising contacting the mucosa of said mammal needing supplemental steroid hormones with an effective amount of a crystalline complex of a steroid hormone with gamma-cyclodextrin.
Claim 6
Independent Claim
39 words
A method of treating a mammal needing supplemental steroid hormones by administering steroid hormones comprising contacting the mucosa of said mammal needing supplemental steroid hormones with an effective amount of a crystalline complex of a steroid hormone with gamma-cyclodextrin.
Claim 7
Dependent Claim
20 words
The method of claim 4 wherein the steroid hormone is selected from the group consisting of testosterone, estradiol, and progesterone.
Claim 8
Dependent Claim
11 words
The method of claim 5 wherein the steroid hormone is testosterone.
Claim 9
Dependent Claim
11 words
The method of claim 1 wherein the complex is administered sublingually.
Claim 10
Dependent Claim
11 words
The method of claim 1 wherein the complex is administered buccally.
Claim 11
Dependent Claim
11 words
The method of claim 1 wherein the complex is administered rectally.
Claim 12
Dependent Claim
11 words
The method of claim 1 wherein the complex is administered ocularly.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1992-10-30 | 1993-05-01 | 1993-10-31 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1996-10-30 | 1997-05-01 | 1997-10-31 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2000-10-30 | 2001-05-01 | 2001-10-31 | $7700.00 | Window Closed / Lapsed |