US4874601A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Radiolabelling kit
Assignee: Draximage Inc
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Filing: 1988-06-14
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Granted: 1989-10-17
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Expires: 2008-06-14
Abstract
Abstract A kit for the direct and rapid preparation of radiolabelled compounds is disclosed comprising a Resin-S-Hg-R component where R is an organic group together with MZ* where M is an alkali metal and Z* is a radiohalogen isotope.
Inventors
- 👤 Richard J. Flanagan
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-28 23:31
CPC Classifications
A; A61; A61K; A61K51/00; A61K51/12; A61K51/1282; A61K2123/00
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
52 words
A kit for direct preparation of radio-labeled compounds of the formula R-Z which comprises (a) a vessel component containing a Resin-S-Hg-R (A) ingredient and a halogen-containing oxidizing agent wherein R is an organic group, and (b) a source of MZ*, wherein M is an alkali metal and Z* is a halogen isotope.
Claim 2
Dependent Claim
52 words
A kit for direct preparation of radio-labeled compounds of the formula R-Z which comprises (a) a vessel component containing a Resin-S-Hg-R (A) ingredient and a halogen-containing oxidizing agent wherein R is an organic group, and (b) a source of MZ*, wherein M is an alkali metal and Z* is a halogen isotope.
Claim 3
Dependent Claim
21 words
The kit of claim 1 wherein Z is 131 I, 123 I, 125 I, 211 At, 77 Br or 75 Br.
Claim 4
Dependent Claim
53 words
The kit of claim 1 wherein R is cholest-5-en-3-β-olyl, carboxy-C 5 -C 10 hydrocarbonaryl, C 1 -C 8 alkyl, C 2 -C 8 alkenyl, aminoC 5 -C 10 hydrocarbonaryl, hippuric acid residue, or heterocyclic having 4 to 7 ring atoms of which 1 to 3 are heteroatoms selected from O, N, or S.
Claim 5
Dependent Claim
9 words
The kit of claim 1 wherein M is Na.
Claim 6
Dependent Claim
15 words
The claim 1 kit wherein the halogen-containing oxidizing agent ingredient is on a support material.
Claim 7
Dependent Claim
53 words
A method of preparing a radiolabelled compound RZ* which comprises mixing a mixture of a Resin-S-Hg-R component (A) and a halogen containing oxidizing agent with MZ*, in a solvent followed by removing the solvent to obtain the desired RZ* wherein the R, Z*, component (A), and M are defined as in claim 1.
Claim 8
Dependent Claim
10 words
The kit of claim 1 wherein Z is 131 I.
Claim 9
Dependent Claim
9 words
The kit of claim 7 wherein R is ##STR3##
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1992-10-16 | 1993-04-17 | 1993-10-17 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1996-10-16 | 1997-04-17 | 1997-10-17 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2000-10-16 | 2001-04-17 | 2001-10-17 | $7700.00 | Window Closed / Lapsed |