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US4871776A
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2,5-anhydro-1,6-dihalo-1,6-dideoxy-D-mannitol
Assignee: Monell Chemical Senses Center
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Filing: 1987-10-22
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Granted: 1989-10-03
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Expires: 2007-10-22
Abstract
Abstract A novel fructose analog is disclosed which has been found to modify the food intake of mammals. If administered during the diurnal fasting period, the mammals increase their food intakes. If administered during the diurnal feeding period, food intake is decreased. The compound is 2,5-anhydro-1,6-dihalo-1,6-dideoxy-D-mannitol, preferably 2,5-anhydro-1,6-dichloro-dideoxy-D-mannitol ("Charmitol").
Inventors
- 👤 Michael J. DiNovi
- 👤 Robert J. Rafka
- 👤 Mark I. Friedman
- 👤 Michael G. Tordoff
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 22:27
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/70; A61K31/7004; A23; A23K; A23K20/00; A23K20/10; A23K20/163; A23L; A23L33/00; A23L33/20; A61K31/33; A61K31/335; A61K31/34; A61P; A61P1/00; A61P3/00; A61P3/08
Claims Analysis
Total Claims: 15
Claim 1
Independent Claim
13 words
A novel composition useful for modifying the food intake of mammals, comprising: 2,5-anhydro-1,6-dihalo-1,6-dideoxy-D-mannitol.
Claim 2
Dependent Claim
13 words
A novel composition useful for modifying the food intake of mammals, comprising: 2,5-anhydro-1,6-dihalo-1,6-dideoxy-D-mannitol.
Claim 3
Dependent Claim
12 words
The composition of claim 1 wherein said halo groups are chloro groups.
Claim 4
Independent Claim
29 words
A method of modifying the food intake in mammals consisting essentially of the step of administering to said mammals an amount of 2,5-anhydro-1,6-dihalo-1,6-dideoxy-D-manniol effective to modify said food intake.
Claim 5
Independent Claim
29 words
A method of modifying the food intake in mammals consisting essentially of the step of administering to said mammals an amount of 2,5-anhydro-1,6-dihalo-1,6-dideoxy-D-manniol effective to modify said food intake.
Claim 6
Dependent Claim
13 words
The method of claim 3 wherein said method consists essentially of administering 2,5-anhydro-1,6-dichloro-1,6-dideoxy-D-mannitol.
Claim 7
Dependent Claim
15 words
The method of claim 3 wherein said amount is at least 50 mg/kg per administration.
Claim 8
Dependent Claim
11 words
The method of claim 5 wherein said amount is administered intragastrically.
Claim 9
Dependent Claim
14 words
The method of claim 6 wherein said amount is about 50-400 mg/kg per administration.
Claim 10
Dependent Claim
31 words
The method of claim 4 wherein said method of modifying is a method of increasing the food intake, and wherein said step of administering comprises administering during a diurnal fasting period.
Claim 11
Dependent Claim
25 words
The method of claim 8 wherein said method comprises administering said mannitol within two hours in advance of the onset of said diurnal fasting period.
Claim 12
Dependent Claim
31 words
The method of claim 4 wherein said method of modifying is a method of decreasing the food intake, and wherein said step of administering comprises administering during a diurnal feeding period.
Claim 13
Dependent Claim
25 words
The method of claim 10 wherein said method comprises administering said mannitol within two hours in advance of the onset of said diurnal feeding period.
Claim 14
Independent Claim
35 words
A method of making 2,5-anhydro-1,6-dichloro-1,6-dideoxy-D-mannitol consisting essentially of the steps of: (a) providing 2,5-anhydro-D-mannitol; (b) halogenating the compound of step (a) by contacting it under reaction conditions with triphenylphosphine and carbon tetrachloride to produce 2,5-anhydro-1,6-dichloro-1,6-dideoxy-D-mannitol.
Claim 15
Independent Claim
35 words
A method of making 2,5-anhydro-1,6-dichloro-1,6-dideoxy-D-mannitol consisting essentially of the steps of: (a) providing 2,5-anhydro-D-mannitol; (b) halogenating the compound of step (a) by contacting it under reaction conditions with triphenylphosphine and carbon tetrachloride to produce 2,5-anhydro-1,6-dichloro-1,6-dideoxy-D-mannitol.
References Cited (Backward Citations)
US4808626A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1992-10-02 | 1993-04-03 | 1993-10-03 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1996-10-02 | 1997-04-03 | 1997-10-03 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2000-10-02 | 2001-04-03 | 2001-10-03 | $7700.00 | Window Closed / Lapsed |