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US4870060A
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Derivatives of γ-cylodextrin
Assignee: Janssen Pharmaceutica NV
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Filing: 1988-07-25
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Granted: 1989-09-26
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Expires: 2008-07-25
Abstract
Abstract Novel derivatives of γ-cyclodextrin, their preparation and their use as complexants and solubilizers. Compositions containing the novel γ-cyclodextrin derivatives and method of preparing such compositions.
Inventors
- 👤 Bernd W. W. Muller
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-08 19:33
CPC Classifications
C; C08; C08B; C08B37/00; C08B37/0006; C08B37/0009; C08B37/0012; A; A61; A61K; A61K47/00; A61K47/50; A61K47/69; A61K47/6949; A61K47/6951; B; B82; B82Y; B82Y5/00
Claims Analysis
Total Claims: 33
Claim 1
Independent Claim
55 words
A composition comprising an active ingredient and a γ-cyclodextrin ether or mixed ether wherein the ether substituents are C 1 -C 6 alkyl, hydroxy C 1 -C 6 alkyl, carboxy C 1 -C 6 alkyl or (C 1 -C 6 alkyloxycarbonyl)C 1 -C 6 alkyl; provided that neither methyl nor hydroxypropyl is a sole substituent.
Claim 2
Dependent Claim
55 words
A composition comprising an active ingredient and a γ-cyclodextrin ether or mixed ether wherein the ether substituents are C 1 -C 6 alkyl, hydroxy C 1 -C 6 alkyl, carboxy C 1 -C 6 alkyl or (C 1 -C 6 alkyloxycarbonyl)C 1 -C 6 alkyl; provided that neither methyl nor hydroxypropyl is a sole substituent.
Claim 3
Dependent Claim
29 words
A composition according to claim 1 wherein the ether substituents are C 1 -C 3 alkyl, hydroxy C 2 -C 4 alkyl or carboxy C 1 -C 2 alkyl.
Claim 4
Dependent Claim
20 words
A composition according to claim 1 wherein the ether substituents are methyl, ethyl, isopropyl, hydroxyethyl, hydroxypropyl, hydroxybutyl, carboxymethyl or carboxyethyl.
Claim 5
Dependent Claim
52 words
A composition comprising an active ingredient and a γ-cyclodextrin ether or mixed ether wherein the ether substituents are C 1 -C 3 alkyl, hydroxy C 2 -C 4 alkyl or carboxy C 1 -C 2 alkyl and wherein the degree of substitution is in the range of 0.125 to less than 2.
Claim 6
Dependent Claim
52 words
A composition comprising an active ingredient and a γ-cyclodextrin ether or mixed ether wherein the ether substituents are C 1 -C 3 alkyl, hydroxy C 2 -C 4 alkyl or carboxy C 1 -C 2 alkyl and wherein the degree of substitution is in the range of 0.125 to less than 2.
Claim 7
Dependent Claim
29 words
A composition according to claim 4 wherein the ether substituent is hydroxyethyl or hydroxypropyl and the average molar substitution is in the range of 0.3 to less than one.
Claim 8
Dependent Claim
13 words
A composition according to claim 1, wherein the active ingredient is a drug.
Claim 9
Dependent Claim
13 words
A composition according to claim 4, wherein the active ingredient is a drug.
Claim 10
Dependent Claim
13 words
A composition according to claim 5, wherein the active ingredient is a drug.
Claim 11
Dependent Claim
41 words
A composition according to claim 6, wherein the drug is a non-steroid anti-rheumatic agent, a steroid, a cardiac glycoside or a derivative of benzodiazepine, benzimidazole, piperidine, piperazine, imidazole, triazole, pyridazine, 1,2,4-triazinedione, 2,3,5,6-tetrahydro-imidazo[2,1-b]thiazole or hydratropic acid, or an amide or trialkylamine derivative.
Claim 12
Dependent Claim
41 words
A composition according to claim 7, wherein the drug is a non-steroid anti-rheumatic agent, a steroid, a cardiac glycoside or a derivative of benzodiazepine, benzimidazole, piperidine, piperazine, imidazole, triazole, pyridazine, 1,2,4-triazinedione, 2,3,5,6-tetrahydro-imidazo[2,1-b]thiazole or hydratropic acid, or an amide or trialkylamine derivative.
Claim 13
Dependent Claim
41 words
A composition according to claim 8, wherein the drug is a non-steroid anti-rheumatic agent, a steroid, a cardiac glycoside or a derivative of benzodiazepine, benzimidazole, piperidine, piperazine, imidazole, triazole, pyridazine, 1,2,4-triazinedione, 2,3,5,6-tetrahydro-imidazo[2,1-b]thiazole or hydratropic acid, or an amide or trialkylamine derivative.
Claim 14
Dependent Claim
31 words
A composition according to claim 6, wherein the drug is a derivative of benzodiazepine, benzimidazole, piperidine, piperazine, imidazole, triazole, pyridazine, 1,2,4-triazinedione, 2,3,5,6-tetrahydro-imidazo[2,1-b]thiazole or hydratropic acid, or an amide or trialkylamine derivative.
Claim 15
Dependent Claim
31 words
A composition according to claim 7, wherein the drug is a derivative of benzodiazepine, benzimidazole, piperidine, piperazine, imidazole, triazole, pyridazine, 1,2,4-triazinedione, 2,3,5,6-tetrahydro-imidazo[2,1-b]thiazole or hydratropic acid, or an amide or trialkylamine derivative.
Claim 16
Dependent Claim
31 words
A composition according to claim 8, wherein the drug is a derivative of benzodiazepine, benzimidazole, piperidine, piperazine, imidazole, triazole, pyridazine, 1,2,4-triazinedione, 2,3,5,6-tetrahydro-imidazo[2,1-b]thiazole or hydratropic acid, or an amide or trialkylamine derivative.
Claim 17
Dependent Claim
21 words
A composition according to claim 6, wherein the drug is selected from the group consisting of etomidate, ketoconazole, itraconazole and flunarizine.
Claim 18
Dependent Claim
21 words
A composition according to claim 7, wherein the drug is selected from the group consisting of etomidate, ketoconazole, itraconazole and flunarizine.
Claim 19
Dependent Claim
21 words
A composition according to claim 8, wherein the drug is selected from the group consisting of etomidate, ketoconazole, itraconazole and flunarizine.
Claim 20
Dependent Claim
13 words
A composition according to claim 4, wherein the active ingredient is a drug.
Claim 21
Dependent Claim
41 words
A composition according to claim 18, wherein the drug is a non-steroid anti-rheumatic agent, a steroid, a cardiac glycoside or a derivative of benzodiazepine, benzimidazole, piperidine, piperazine, imidazole, triazole, pyridazine, 1,2,4-triazinedione, 2,3,5,6-tetrahydro-imidazo[2,1-b]thiazole or hydratropic acid, or an amide or trialkylamine derivative.
Claim 22
Dependent Claim
31 words
A composition according to claim 18, wherein the drug is a derivative of benzodiazepine, benzimidazole, piperidine, piperazine, imidazole, triazole, pyridazine, 1,2,4,-triazinedione, 2,3,5,6-tetrahydro-imidazo[2,1-b]thiazole or hydratropic acid, or an amide or trialkylamine derivative.
Claim 23
Dependent Claim
31 words
A composition according to claim 4, wherein the drug is a derivative of benzodiazepine, benzimidazole, piperidine, piperazine, imidazole, triazole, pyridazine, 1,2,4-triazinedione, 2,3,5,6-tetrahydra-imidazo[2,1-b]thiazole or hydratropc acid, or an amide or trialkylamine derivative.
Claim 24
Dependent Claim
21 words
A composition according to claim 4, wherein the drug is selected from the group consisting of etomidate, ketoconazole, itraconazole and flunarizine.
Claim 25
Dependent Claim
35 words
A method of preparing a composition according to claim 1, characterized in that the γ-cyclodextrin ether is dissolved in water and that the active ingredient is added whereafter the thus obtained solution is optionally dried.
Claim 26
Dependent Claim
35 words
A method of preparing a composition according to claim 2 characterized in that the γ-cyclodextrin ether is dissolved in water and that the active ingredient is added whereafter the thus obtained solution is optionally dried.
Claim 27
Dependent Claim
35 words
A method of preparing a composition according to claim 4 characterized in that the γ-cyclodextrin ether is dissolved in water and that the active ingredient is added whereafter the thus obtained solution is optionally dried.
Claim 28
Dependent Claim
30 words
A method according to claim 23, wherein the residue after removal of the solvent is pulverized and, optionally after addition of further ingredients, converted into a solid form for administration.
Claim 29
Dependent Claim
16 words
A method according to claim 26, wherein further physiologically acceptable substances are added to the water.
Claim 30
Dependent Claim
24 words
A method according to claim 27, wherein sodium chloride, glucose, mannitol, sorbitol, xylitol or a phosphate or citrate buffer are added to the water.
Claim 31
Dependent Claim
30 words
A method according to claim 24, wherein the residue after removal of the solvent is pulverized and, optionally after addition of further ingredients, converted into a solid form for administration.
Claim 32
Dependent Claim
16 words
A method according to claim 29, wherein further physiologically acceptable substances are added to the water.
Claim 33
Dependent Claim
24 words
A method according to claim 30, wherein sodium chloride, glucose, mannitol, sorbitol, xylitol or a phosphate or citrate buffer are added to the water.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
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| 3.5 Years (Year 4) | 1992-09-25 | 1993-03-27 | 1993-09-26 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1996-09-25 | 1997-03-27 | 1997-09-26 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2000-09-25 | 2001-03-27 | 2001-09-26 | $7700.00 | Window Closed / Lapsed |