Aryl-substituted naphthyridine and pyridopyrazine derivatives

Claim 1

A compound having the structural formula ##STR22## and pharmaceutically acceptable salts thereof, wherein: X represents CH or N; A represents O or S; m is an integer of from 0 to 2; n is an integer of from 0 to 2; R 1 and R 2 are the same or different and each is independently selected from H or alkyl containing 1 to 6 carbon atoms; W represents a covalent bond; B represents alkylene having from 2 to 8 carbon atoms, which alkylene may be optionally substituted with a group selected from -OH, -F, alkyl having from 1 to 4 carbon atoms, --CH 2 OH, --CHO, --CO 2 H, --COR 3 , {wherein R 3 is selected from --NHR 4 , --N(R 4 ) 2 , or --OR 4 and R 4 is alkyl of 1 to 6 carbon atoms}, or --CN; Q represents an aryl group containing from 6 to 15 carbon atoms or an aromatic heterocyclic group containing from 3 to 14 carbon atoms and having at least one O, S, or N in the ring, which aryl or aromatic heterocyclic group can optionally be substituted with up to 3 substituents Y as defined below; and each Y substituent is independently selected form --OH, hydroxymethyl, alkyl containing from 1 to 6 carbon atoms, halo, --N 2 , alkoxy containing 1 to 6 carbon atoms, --CF 3 , --CN, cycloalkyl containing 3 to 7 carbon atoms, alkenyloxy containing from 3 to 6 carbon atoms, alkynyloxy containing from 3 to 6 carbon atoms, --S(O) p -R 4 , {wherein R 4 is as defined above and p is an integer of from 0 to 2}, --CO--R 5 {wherein R 5 represents --OH, --NH 2 , --NHR 4 , --N(R 4 ) 2 or --OR 4 in which R 4 is as defined above}, --O--D--COR 5 , {wherein D represents alkylene having from 1 to 4 carbon atoms and R 5 is a defined above}, --NH 2 , --NHR 4 , --H(R 4 ) 2 {wherein R.sup. 4 is as defined above} or --NHCOH.