US4865848A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Skin permeation enhancer compositions using sucrose esters
Assignee: Alza Corp
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Filing: 1987-02-26
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Granted: 1989-09-12
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Expires: 2007-02-26
Abstract
Abstract A method for enhancing the transdermal flux of a transdermally deliverable drug through intact skin is described in which the drug is delivered simultaneously with sucrose monolaurate or a mixture of sucrose esters of coconut fatty acids, which is predominantly sucrose monolaurate. Preferred embodiments of therapeutic systems for delivering the drug and the sucrose ester employ a matrix containing drug at a concentration above saturation.
Inventors
- 👤 Yu-Ling Cheng
- 👤 Robert M. Gale
- 👤 Edna Sugihara
- 👤 Harold F. Sanders
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 07:22
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/70; A61K9/7023; A61K9/703; A61K9/7038; A61K9/7046; A61K9/7053; A61K47/00; A61K47/06; A61K47/26; A61K9/7076; A61K9/7084
Claims Analysis
Total Claims: 5
Claim 1
Independent Claim
57 words
A method for enhancing the transdermal flux of a biologically active agent through intact skin which comprises placing a source of said agent in agent transmitting relationship to said intact skin in the presence of a permeation enhancing amount of a permeation enhancer consisting essentially of a sucrose monolaurate mixed with sucrose esters of coconut fatty acids.
Claim 2
Independent Claim
57 words
A method for enhancing the transdermal flux of a biologically active agent through intact skin which comprises placing a source of said agent in agent transmitting relationship to said intact skin in the presence of a permeation enhancing amount of a permeation enhancer consisting essentially of a sucrose monolaurate mixed with sucrose esters of coconut fatty acids.
Claim 3
Dependent Claim
22 words
The method of claim 1 wherein the source of said agent contains agent in excess of its saturation concentration in said source.
Claim 4
Dependent Claim
86 words
In a method for transdermally administering a biologically active agent by permeation through skin which comprises: (a) placing a source of said agent and a permeation enhancer therefor in agent and permeation enhancer transmitting relationship to said skin, and (b) maintaining said source in contact with said skin for a period of time sufficient to produce a beneficial effect; the improvements wherein said permeation enhancer consists essentially of a material selected from the group consisting of sucrose monolaurate mixed with sucrose esters of coconut fatty acids.
Claim 5
Dependent Claim
86 words
In a method for transdermally administering a biologically active agent by permeation through skin which comprises: (a) placing a source of said agent and a permeation enhancer therefor in agent and permeation enhancer transmitting relationship to said skin, and (b) maintaining said source in contact with said skin for a period of time sufficient to produce a beneficial effect; the improvements wherein said permeation enhancer consists essentially of a material selected from the group consisting of sucrose monolaurate mixed with sucrose esters of coconut fatty acids.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1992-09-11 | 1993-03-13 | 1993-09-12 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1996-09-11 | 1997-03-13 | 1997-09-12 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2000-09-11 | 2001-03-13 | 2001-09-12 | $7700.00 | Window Closed / Lapsed |