US4861589A
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Method for therapeutically treating abnormal cells expressing a major histocompatibility complex class II antigen using cytolytic inducer T4 cells
Assignee: Boston University
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Filing: 1987-03-23
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Granted: 1989-08-29
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Expires: 2007-03-23
Abstract
Abstract The present invention provides a lymphocyte-mediated immunotherapy for the treatment of human or animal subjects afflicted with abnormal or tumor cells which express a MHC Class II antigen on their surface. The method utilizes inducer T-cell clones or lines having a demonstrable specificity for an identifiable antigen. These T-cells are activated in-vivo to express cytolytic and therapeutic activity against the abnormal or tumor cells in the subject.
Inventors
- 👤 Shyr-Te Ju
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-03 01:52
CPC Classifications
A; A61; A61K; A61K40/00; A61K40/40; A61K40/41; A61K40/42; A61K40/10; A61K40/11; A61K40/4202; A61K40/421; A61K40/4213; A61K2239/00; A61K2239/31; A61K2239/38; A61K2239/46; A61K2239/48; Y; Y10; Y10S; Y10S530/00; Y10S530/806; Y10S530/808; Y10S530/827; Y10S530/828
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
132 words
An in-vivo method for therapeutically treating a living subject afflicted with abnormal cells which express a major histocompatibility complex Class II antigen, said method comprising the steps of: administering a plurality of non-activated inducer T-cell lymphocytes to the living subject, said non-activated inducer T-cell lymphocytes having a demonstratable specificity for another antigen in addition to a major histocompatibility Class II antigen; introducing said other antigen to the abnormal cells within the subject at a desired time such that the abnormal cells take up said introduced other antigen and act in-vivo as antigen-presenting cells; allowing said administered T-cell lymphocytes to become activated in-vivo by said introduced other antigen; and waiting for said in-vivo activated inducer T-cell lymphocytes to express cytolytic activity against said antigen-presenting cells comprising the abnormal cells in the living subject.
Claim 2
Dependent Claim
132 words
An in-vivo method for therapeutically treating a living subject afflicted with abnormal cells which express a major histocompatibility complex Class II antigen, said method comprising the steps of: administering a plurality of non-activated inducer T-cell lymphocytes to the living subject, said non-activated inducer T-cell lymphocytes having a demonstratable specificity for another antigen in addition to a major histocompatibility Class II antigen; introducing said other antigen to the abnormal cells within the subject at a desired time such that the abnormal cells take up said introduced other antigen and act in-vivo as antigen-presenting cells; allowing said administered T-cell lymphocytes to become activated in-vivo by said introduced other antigen; and waiting for said in-vivo activated inducer T-cell lymphocytes to express cytolytic activity against said antigen-presenting cells comprising the abnormal cells in the living subject.
Claim 3
Dependent Claim
133 words
An in-vivo method for therapeutically treating a living subject afflicted with tumor cells which express a major histocompatibility complex Class II antigen, said method comprising the steps of: administering a plurality of non-activated inducer T-cell lymphocytes to the living subject, said non-activated inducer T-cell lymphocytes having a demonstratable specificity for an exogenous antigen in addition to a major histocompatibility Class II antigen; introducing said exogenous antigen to the tumor cells within the subject at a desired time such that the tumor cells take up said introduced exogenous antigen and act in-vivo as antigen-presenting cells; allowing said administered T-cell lymphocytes to become activated in-vivo by said introduced exogenous antigen; and waiting for said in-vivo activated inducer T-cell lymphocytes to express cytolytic activity against said antigen-presenting cells comprising the tumor cells in the living subject.
Claim 4
Dependent Claim
133 words
An in-vivo method for therapeutically treating a living subject afflicted with tumor cells which express a major histocompatibility complex Class II antigen, said method comprising the steps of: administering a plurality of non-activated inducer T-cell lymphocytes to the living subject, said non-activated inducer T-cell lymphocytes having a demonstratable specificity for an exogenous antigen in addition to a major histocompatibility Class II antigen; introducing said exogenous antigen to the tumor cells within the subject at a desired time such that the tumor cells take up said introduced exogenous antigen and act in-vivo as antigen-presenting cells; allowing said administered T-cell lymphocytes to become activated in-vivo by said introduced exogenous antigen; and waiting for said in-vivo activated inducer T-cell lymphocytes to express cytolytic activity against said antigen-presenting cells comprising the tumor cells in the living subject.
Claim 5
Dependent Claim
17 words
The method as recited in claim 1 or 2 wherein said inducer T-cell lymphocytes comprise cloned T-cells.
Claim 6
Dependent Claim
22 words
The method as recited in claim 3 wherein said cloned inducer T-cell lymphocytes are derived from the T-cells of the afflicted subject.
Claim 7
Dependent Claim
23 words
The method as recited in claim 1 or 2 wherein the major histocompatablity complex Class II antigen of said cells is constitutively expressed
Claim 8
Dependent Claim
23 words
The method as recited in claim 1 or 2 wherein the major histocompatability complex Class II antigen of said cells is inductively expressed.
Claim 9
Dependent Claim
19 words
The method as recitedin claim 1 or 2 wherein said inducer T-cell lymphocytes administered to the subject are syngeneic.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1992-08-28 | 1993-02-27 | 1993-08-29 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1996-08-28 | 1997-02-27 | 1997-08-29 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2000-08-28 | 2001-02-27 | 2001-08-29 | $7700.00 | Window Closed / Lapsed |