US4695459A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Method of treating autoimmune diseases that are mediated by Leu3/CD4 phenotype T cells
Assignee: Leland Stanford Junior University
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Filing: 1984-12-26
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Granted: 1987-09-22
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Expires: 2004-12-26
Abstract
Abstract Certain autoimmune diseases such as multiple sclerosis, rheumatoid arthritis, and systemic lupus erythematosus may be prevented or attenuated by in vivo treatment with a complement-fixing anti-Leu3 (CD4) antibody that is cytotoxic to Leu3 (CD4) phenotype T cells.
Inventors
- 👤 Lawrence Steinman
- 👤 Matthew K. Waldor
- 👤 Subramanian Sriram
- 👤 Leonard A. Herzenberg
- 👤 Leonore A. Herzenberg
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-03 03:32
CPC Classifications
C; C07; C07K; C07K16/00; C07K16/18; C07K16/28; C07K16/2803; C07K16/2812; A; A61; A61P; A61P37/00; A61P37/02; A61P37/06; Y; Y10; Y10S; Y10S424/00; Y10S424/81; Y10S530/00; Y10S530/868
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
38 words
A method of treating a patient for an autoimmune disease that is mediated by Leu3(CD4) phenotype T cells comprising parenterally administering a therapeutically effective amount of an anti-Leu3(CD4) antibody that binds to said T cells to the patient.
Claim 2
Independent Claim
38 words
A method of treating a patient for an autoimmune disease that is mediated by Leu3(CD4) phenotype T cells comprising parenterally administering a therapeutically effective amount of an anti-Leu3(CD4) antibody that binds to said T cells to the patient.
Claim 3
Dependent Claim
11 words
The method of claim 1 wherein the patient is a human.
Claim 4
Dependent Claim
27 words
The method of claim 2 wherein the disease is multiple sclerosis, rheumatoid arthritis, systemic lupus erythematosus, psoriasis, juvenile onset diabetes, Sjogren's disease, thyroid disease, or myasthenia gravis.
Claim 5
Dependent Claim
11 words
The method of claim 1 wherein the disease is multiple sclerosis.
Claim 6
Dependent Claim
19 words
The method of claim 1 wherein said amount is in the range of about 10 and about 100 mg.
Claim 7
Dependent Claim
17 words
The method of claim 1 wherein said antibody is a monoclonal antibody of class IgG1 or IgG2.
Claim 8
Dependent Claim
19 words
The method of claim 6 wherein the association constant of the antibody is at least about 10 7 L/mol.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1990-09-21 | 1991-03-23 | 1991-09-22 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1994-09-21 | 1995-03-23 | 1995-09-22 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1998-09-21 | 1999-03-23 | 1999-09-22 | $7700.00 | Window Closed / Lapsed |