Patent US4860744A successfully refreshed from Google Patents.
US4860744A
Expired / Lapsed
US
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Thermoelectrically controlled heat medical catheter
Assignee: ANAD RAJ K MD 210 LINCOLN STREET WORCESTER MASSACHUSETTS
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Filing: 1987-11-02
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Granted: 1989-08-29
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Expires: 2007-11-02
Abstract
Abstract A system and method are disclosed for providing precisely controlled heating (and cooling in come case) of a small region of body tissue to effectuate the removal of tumors and deposits. such as atheromatous plaque, without causing damage to healthy surrounding tissue, e.g. arterial walls. Such precisely controlled heating is produced through thermoelectric and resistive heating, and thermoelectric control of a heated probe tip. The system includes a probe tip with N-doped and P-doped legs of semincoductor material, a catheter to which the probe tip is attached for insertion into a patient's body, and a system control mechanism. The probe may be used for reduction and/or removal of atheromatous obstruction in arteries or veins. It may also be used for destruction of diseased tissue and/or tumors in various parts of the body, such as the brain or the bladder. The probe may be configured for either tip heating or for side heating.
Inventors
- 👤 Norman J. Johnson
- 👤 Raj K. Anand
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 18:12
CPC Classifications
A; A61; A61B; A61B18/00; A61B18/04; A61B18/08; A61B18/082; A61F; A61F7/00; A61F7/12; A61B18/12; A61B18/1206; A61B17/00; A61B17/22; A61B2017/22001; A61B2018/00005; A61B2018/00047; A61B2018/00053; A61B2018/00059; A61B2018/00071; A61B2018/00083; A61B2018/00089; A61B2018/00095; A61B2018/00273; A61B2018/00279; A61B2018/00285; A61B2018/00636; A61B2018/00696; A61B2018/00726; A61B2018/00773; A61B2018/00791; A61B2018/087; A61F7/007; A61F2007/0071; A61F2007/0075
Claims Analysis
Total Claims: 34
Claim 1
Independent Claim
135 words
An apparatus for applying highly controlled, localized heating or cooling to precise points in a patient to treat the patient comprising: a P-doped thermocouple leg including first and second end portions and an N-doped thermocouple leg including first and second end portions, said legs being connected at said first end portions to form a probe tip junction and not being connected at said second end portions, said legs being oriented to be opposite each other; a metal sleeve surrounding said unconnected second end portions of said thermocouple legs; a layer of thermally conductive, electrically insulative material separating said thermocouple legs from said metal sleeve; means for delivering said pair of thermocouple legs into a patient's body; and means for passing a current through said pair of legs to heat or cool said probe tip junction.
Claim 2
Independent Claim
135 words
An apparatus for applying highly controlled, localized heating or cooling to precise points in a patient to treat the patient comprising: a P-doped thermocouple leg including first and second end portions and an N-doped thermocouple leg including first and second end portions, said legs being connected at said first end portions to form a probe tip junction and not being connected at said second end portions, said legs being oriented to be opposite each other; a metal sleeve surrounding said unconnected second end portions of said thermocouple legs; a layer of thermally conductive, electrically insulative material separating said thermocouple legs from said metal sleeve; means for delivering said pair of thermocouple legs into a patient's body; and means for passing a current through said pair of legs to heat or cool said probe tip junction.
Claim 3
Dependent Claim
31 words
The apparatus of claim 1 wherein said metal sleeve is bonded to an end of a catheter and said first end portions forming said probe tip junction extend from said catheter.
Claim 4
Dependent Claim
25 words
The apparatus of claim 1 wherein said pair of thermocouple legs are constructed from materials having a high thermoelectric potential and a low electric resistivity.
Claim 5
Dependent Claim
16 words
The apparatus of claim 1 wherein said pair of thermocouple legs are constructed from semiconductor material.
Claim 6
Dependent Claim
30 words
The apparatus of claim 1 wherein said pair of thermocouple legs are constructed from a semiconductor material selected from the group consisting of silicon and alloys of silicon and germanium.
Claim 7
Dependent Claim
28 words
The apparatus of claim 1 including a molybdenum silicide plate joined to said first end portions of the pair of thermocouple legs to form said probe tip junction.
Claim 8
Dependent Claim
37 words
The apparatus of claim 1 including a pair of connector wires individually attached to the pair of thermocouple legs near said second end portion remote from said first end portion to form a pair of reference junctions.
Claim 9
Dependent Claim
18 words
The apparatus of claim 7 including means for determining and controlling the temperature of said probe tip junction.
Claim 10
Dependent Claim
55 words
The apparatus of claim 8 wherein said means for determining and controlling the temperature of said probe tip junction includes a temperature sensor thermally connected to at least one of the thermocouple legs at a location away from said probe tip junction and means for periodically interrupting the flow of current through said thermocouple legs.
Claim 11
Dependent Claim
13 words
The apparatus of claim 1 having more than one pair of thermocouple legs.
Claim 12
Dependent Claim
19 words
The apparatus of claim 10 wherein said more than one pair of thermocouple legs are constructed from semiconductor material.
Claim 13
Dependent Claim
33 words
The apparatus of claim 10 wherein said more than one pair of thermocouple legs are constructed from a semiconductor material selected from the group consisting of silicon and alloys of silicon and germanium.
Claim 14
Dependent Claim
17 words
The apparatus of claim 10 wherein each of said thermocouple legs is electrically separated along its length.
Claim 15
Dependent Claim
25 words
The apparatus of claim 10 wherein said more than one pair of thermocouple legs are joined at a first end in pairs P to N.
Claim 16
Dependent Claim
25 words
The apparatus of claim 14 wherein said more than one pair of thermocouple legs are joined at a second end in pairs N to P.
Claim 17
Dependent Claim
39 words
The apparatus of claim 1 wherein said layer of thermally conductive, electrically insulative material which insulates said thermocouple legs from said metal sleeve defines a channel through said apparatus substantially parallel to said legs to accommodate a guide wire.
Claim 18
Dependent Claim
26 words
The apparatus of claim 1 wherein said thermocouple legs are bent such that said probe tip junction faces perpendicularly to a longitudinal axis of said apparatus.
Claim 19
Dependent Claim
38 words
The apparatus of claim 17 including a balloon positioned adjacent to a probe tip adjacent to said probe tip junction, said balloon being inflatable within an artery to press said probe tip junction against said facing arterial wall.
Claim 20
Dependent Claim
24 words
The apparatus of claim 17 wherein the pair of thermocouple legs are constructed from materials having a high thermo-electric potential and low electrical resistivity.
Claim 21
Dependent Claim
17 words
The apparatus of claim 17 wherein the pair of thermocouple legs are constructed from a semiconductor material.
Claim 22
Dependent Claim
30 words
The apparatus of claim 17 wherein the pair of thermocouple legs are constructed from a semiconductor material selected from the group consisting of silicon and alloys of silicon and germanium.
Claim 23
Dependent Claim
27 words
The apparatus of claim 17 including a molybdenum plate joined to said first end portions of the pair of thermocouple legs to form said probe tip junction.
Claim 24
Dependent Claim
37 words
The apparatus of claim 17 including a pair of connector wires individually connected to the pair of thermocouple legs near said second end portions remote from said first end portions to form a pair of reference junctions.
Claim 25
Dependent Claim
13 words
The apparatus of claim 17 having more than one pair of thermocouple legs.
Claim 26
Dependent Claim
19 words
The apparatus of claim 24 wherein said more than one pair of thermocouple legs are constructed from semiconductor material.
Claim 27
Dependent Claim
33 words
The apparatus of claim 24 wherein said more than one pair of thermocouple legs are constructed from a semiconductor material selected from the group consisting of silicon and alloys of silicon and germanium.
Claim 28
Dependent Claim
17 words
The apparatus of claim 24 wherein each of said thermocouple legs is electrically separated along its length.
Claim 29
Dependent Claim
26 words
The apparatus of claim 24 wherein said more than one pair of thermocouple legs are joined at a first end in pairs of P to N.
Claim 30
Dependent Claim
28 words
The apparatus of claim 24 wherein said more than one pair of thermocouple legs are joined at a second end in pairs N to P with metal plates.
Claim 31
Dependent Claim
28 words
The apparatus of claim 24 wherein a P-doped leg and an N-doped leg of said more than one pair of thermocouple legs are attached to two connector wires.
Claim 32
Dependent Claim
19 words
The apparatus of claim 1 including means for determining and precisely controlling the temperature of said probe tip junction.
Claim 33
Independent Claim
218 words
An apparatus for applying highly controlled localized heating to precise joints within a patient to melt or vaporize undesirable organic material comprising: a probe tip including a P-doped leg of semiconductor thermoelectric material having first and second end portions and an N-doped leg of semiconductor thermoelectric material having first and second end portions arranged substantially parallel to said P-doped leg and electrically insulated from said P-doped leg along the lengths of said legs, an electrically conductive shoe connected to said first end portions of said legs to form a probe tip junction, said legs being unconnected at their second end portions, a first electrical lead attached to said P-doped leg to form a first reference junction, and a second electrical lead attached to said N-doped leg to form a second reference junction; a metal sleeve surrounding said second end portions of said legs; a layer of thermally conductive, electrically insulative material separating said thermocouple legs from said metal sleeve; means for delivering said probe tip to a selected location within the body of a patient; and means for passing an electrical current through said electrical leads and said legs to heat said shoe to a selected temperature sufficient to melt or vaporize undesirable organic material at said selected location and for precisely controlling the temperature of said shoe.
Claim 34
Independent Claim
218 words
An apparatus for applying highly controlled localized heating to precise joints within a patient to melt or vaporize undesirable organic material comprising: a probe tip including a P-doped leg of semiconductor thermoelectric material having first and second end portions and an N-doped leg of semiconductor thermoelectric material having first and second end portions arranged substantially parallel to said P-doped leg and electrically insulated from said P-doped leg along the lengths of said legs, an electrically conductive shoe connected to said first end portions of said legs to form a probe tip junction, said legs being unconnected at their second end portions, a first electrical lead attached to said P-doped leg to form a first reference junction, and a second electrical lead attached to said N-doped leg to form a second reference junction; a metal sleeve surrounding said second end portions of said legs; a layer of thermally conductive, electrically insulative material separating said thermocouple legs from said metal sleeve; means for delivering said probe tip to a selected location within the body of a patient; and means for passing an electrical current through said electrical leads and said legs to heat said shoe to a selected temperature sufficient to melt or vaporize undesirable organic material at said selected location and for precisely controlling the temperature of said shoe.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1992-08-28 | 1993-02-27 | 1993-08-29 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1996-08-28 | 1997-02-27 | 1997-08-29 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2000-08-28 | 2001-02-27 | 2001-08-29 | $7700.00 | Window Closed / Lapsed |