Patent US5642047A successfully refreshed from Google Patents.
US4859779A
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Dopamine-β-hydroxylase inhibitors
Assignee: SmithKline Beecham Corp
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Filing: 1989-01-27
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Granted: 1989-08-22
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Expires: 2009-01-27
Abstract
Abstract Potent dopamine- beta -hydroxylase inhibitors having the formula <IMAGE> that are useful to inhibit dopamine- beta -hydroxylase activity, pharmaceutical compositions including these inhibitors, and methods of using these inhibitors to inhibit dopamine- beta -hydroxylase activity in mammals. Also disclosed are novel intermediates useful in preparing the presently invented inhibitors.
Inventors
- 👤 Joseph A. Finkelstein
- 👤 Lawrence I. Kruse
- 👤 Thomas B. Leonard
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 07:27
CPC Classifications
C; C07; C07D; C07D233/00; C07D233/54; C07D233/66; C07D233/90
Claims Analysis
Total Claims: 4
Claim 1
Independent Claim
80 words
A compound represented by the formula: ##STR8## in which: X is H, F, Cl, Br, I, C 1-4 alkyl, CN, NO 2 , SO 2 NH 2 , COOH, OH, CHO, C 1-4 alkyl, CN, CF 3 , SO 2 CH 3 , SO 2 CF 3 , or CO 2 C a H 2a+1 wherein a is 1-5, or any accessible combination thereof of up to 5 substituents; R is hydrogen or C 1-4 alkyl; and n is 0-5.
Claim 2
Dependent Claim
80 words
A compound represented by the formula: ##STR8## in which: X is H, F, Cl, Br, I, C 1-4 alkyl, CN, NO 2 , SO 2 NH 2 , COOH, OH, CHO, C 1-4 alkyl, CN, CF 3 , SO 2 CH 3 , SO 2 CF 3 , or CO 2 C a H 2a+1 wherein a is 1-5, or any accessible combination thereof of up to 5 substituents; R is hydrogen or C 1-4 alkyl; and n is 0-5.
Claim 3
Dependent Claim
11 words
A compound as claimed in claim 1 being the compound N-(2-aminoethyl)-1-(3,5-difluorobenzyl)-2-mercaptoimidazole-5-carbozamide.
Claim 4
Dependent Claim
11 words
A compound as claimed in claim 1 being the compound N-(2-amino-n-butyl)-1-(3,5-difluorobenzyl)-2-mercaptoimidazole-5-carboxamide.
References Cited (Backward Citations)
US4532331A
Cited
US4719223A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1992-08-21 | 1993-02-20 | 1993-08-22 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1996-08-21 | 1997-02-20 | 1997-08-22 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2000-08-21 | 2001-02-20 | 2001-08-22 | $7700.00 | Window Closed / Lapsed |