US4532331A
Expired / Lapsed
US
⏱️ 0.0 years remaining
1-Benzyl-2-aminomethyl imidazole derivatives
Assignee: SmithKline Beecham Corp
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Filing: 1983-04-12
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Granted: 1985-07-30
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Expires: 2003-04-12
Abstract
Abstract Potent DBH inhibitors having the formula: ##STR1## wherein R is --CO 2 H or --CH 2 NHR 1 can be used to inhibit DBH activity in mammals.
Inventors
- 👤 James S. Frazee
- 👤 Carl Kaiser
- 👤 Lawrence I. Kruse
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 07:14
CPC Classifications
C; C07; C07D; C07D233/00; C07D233/54; C07D233/64; A; A61; A61P; A61P43/00; C07C; C07C217/00; C07C217/54; C07C217/56; C07C217/62; C07D233/66; C07D233/84; C07D233/90
Claims Analysis
Total Claims: 5
Claim 1
Independent Claim
84 words
A compound having the formula: ##STR21## wherein Y is --H, --OH, --OCH 3 , --F, --CF 3 or C 1-4 alkyl; X is --H, --OH, --OCH 3 , --F, --CF 3 or C 1-4 alkyl, or any accessible combination thereof up to four substituents and wherein at least one of Y and X is --OH; R 1 is --CH 2 NHR 1 ; R 1 is --H, phenyl or benzyl; and, n is 0-4, or a pharmaceutically acceptable acid addition salt or hydrate thereof.
Claim 2
Dependent Claim
84 words
A compound having the formula: ##STR21## wherein Y is --H, --OH, --OCH 3 , --F, --CF 3 or C 1-4 alkyl; X is --H, --OH, --OCH 3 , --F, --CF 3 or C 1-4 alkyl, or any accessible combination thereof up to four substituents and wherein at least one of Y and X is --OH; R 1 is --CH 2 NHR 1 ; R 1 is --H, phenyl or benzyl; and, n is 0-4, or a pharmaceutically acceptable acid addition salt or hydrate thereof.
Claim 3
Dependent Claim
24 words
The compound of claim 3 wherein X is --H, Y is --OH R 1 is --H or benzyl and n is 1 or 3.
Claim 4
Dependent Claim
17 words
The compound of claim 2 wherein Y is --OH, R 1 is --H and n is 1.
Claim 5
Dependent Claim
17 words
The compound of claim 2 wherein Y is --OH, R 1 is benzyl and n is 1.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1988-07-29 | 1989-01-28 | 1989-07-30 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1992-07-29 | 1993-01-28 | 1993-07-30 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1996-07-29 | 1997-01-28 | 1997-07-30 | $7700.00 | Window Closed / Lapsed |