Patent US4859653A successfully refreshed from Google Patents.
US4859653A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Use of compositions of matter containing N-acylates of alpha aminoacids for the treatment of skin
Assignee: Individual
•
Filing: 1986-12-09
•
Granted: 1989-08-22
•
Expires: 2006-12-09
Abstract
Abstract This invention relates to new compositions of matter for use in treating wrinkling of the human skin. The compositions comprise, as an essential ingredient therein, at least one N-acylate, by butyric acid, of an alpha-amino acid or a salt of said acylate with an inorganic, organic or biologic base or with a metal.
Inventors
- 👤 Jean V. Morelle
- 👤 Eliane M. T. Lauzanne-Morelle
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 13:42
CPC Classifications
C; C07; C07D; C07D207/00; C07D207/02; C07D207/04; C07D207/10; C07D207/16; A; A01; A01N; A01N37/00; A01N37/44; A01N37/46; A01N43/00; A01N43/34; A01N43/36; A01N61/00; A01N63/00; A01N63/50; A61; A61K; A61K31/00; A61K31/185; A61K31/19; A61K31/195; A61K8/00; A61K8/18; A61K8/30; A61K8/40; A61K8/44; A61K8/447; A61K8/49; A61K8/4906; A61K8/4913; A61K8/64; A61K8/65; A61Q; A61Q19/00; A61Q19/08
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
80 words
A method of treating wrinkles of the human skin, said method comprising the topical administration of a composition comprising as an active ingredient at least one N-acylate selected from the group consisting of butyrylglycine, butyryl phenylalanine, butyrylthreonine, butyrylaspartic acid, butyrylvaline, butyryl leucine, dibutyryl lysine, butyrylproline, mono and dibutyryl hydroxyproline, dibutyrylhydroxylysine, butyryl methionine, dibutyryl cystine, butyrylcysteine, butyrylcollagenic acid, butyrylkeratinic acid and butyrylcaseinic acid, said composition comprising a pharmaceutically acceptable carrier and an amount of said active ingredient effective to treat wrinkles.
Claim 2
Independent Claim
80 words
A method of treating wrinkles of the human skin, said method comprising the topical administration of a composition comprising as an active ingredient at least one N-acylate selected from the group consisting of butyrylglycine, butyryl phenylalanine, butyrylthreonine, butyrylaspartic acid, butyrylvaline, butyryl leucine, dibutyryl lysine, butyrylproline, mono and dibutyryl hydroxyproline, dibutyrylhydroxylysine, butyryl methionine, dibutyryl cystine, butyrylcysteine, butyrylcollagenic acid, butyrylkeratinic acid and butyrylcaseinic acid, said composition comprising a pharmaceutically acceptable carrier and an amount of said active ingredient effective to treat wrinkles.
Claim 3
Dependent Claim
20 words
The method of claim 1 wherein said active ingredient is present in an amount from 0.1% to 10% by weight.
Claim 4
Independent Claim
64 words
A method of treating wrinkles of the human skin, said method comprising the topical administration of a composition comprising as an active ingredient at least one N-acylate, said N-acylate being formed by butyric acid acylation of at least one alpha-aminoacid or a salt of said N-acylate, said composition comprising a pharmaceutically acceptable carrier and an amount of said active ingredient effective to treat wrinkles.
Claim 5
Independent Claim
64 words
A method of treating wrinkles of the human skin, said method comprising the topical administration of a composition comprising as an active ingredient at least one N-acylate, said N-acylate being formed by butyric acid acylation of at least one alpha-aminoacid or a salt of said N-acylate, said composition comprising a pharmaceutically acceptable carrier and an amount of said active ingredient effective to treat wrinkles.
Claim 6
Dependent Claim
20 words
The method of claim 3 wherein said active ingredient is present in an amount from 0.1% to 10% by weight.
Claim 7
Dependent Claim
14 words
The method of claim 3 wherein said active ingredient in said composition is butyrylhydroxyproline.
Claim 8
Dependent Claim
38 words
The method of claim 5 wherein the active ingredient is present in the amount of about 1% by weight of the composition and the composition is topically administered to the area to be treated once every two days.
Claim 9
Independent Claim
68 words
A method of treating wrinkles of the human skin, said method comprising the topical administration of a composition comprising as an active ingredient at least one N-acylate being the result of the butyric acid acylation of a mixture of alpha-aminoacids obtained by the complete hydrolysis of one or more proteins, said composition comprising a pharmaceutically acceptable carrier and an amount of said active ingredient effective to treat wrinkles.
Claim 10
Independent Claim
68 words
A method of treating wrinkles of the human skin, said method comprising the topical administration of a composition comprising as an active ingredient at least one N-acylate being the result of the butyric acid acylation of a mixture of alpha-aminoacids obtained by the complete hydrolysis of one or more proteins, said composition comprising a pharmaceutically acceptable carrier and an amount of said active ingredient effective to treat wrinkles.
References Cited (Backward Citations)
US4208421A
Cited
FR2152486A1
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1992-08-21 | 1993-02-20 | 1993-08-22 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1996-08-21 | 1997-02-20 | 1997-08-22 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2000-08-21 | 2001-02-20 | 2001-08-22 | $7700.00 | Window Closed / Lapsed |