US4859419A — Diagnostic manifold apparatus

Claim 1

Independent Claim 130 words

A test vessel for an assay apparatus comprising an enclosed elongated body having an interior test chamber for receiving a test strip therein, an inlet port at one end of the body in fluid communication with said chamber with means to connect the port to an inlet manifold, an outlet port at the end of the body in fluid communication with said chamber opposite said inlet port with means to connect the outlet port to an outlet manifold, at least one injection port disposed between the inlet port and the outlet port in fluid communication with said chamber, and means to limit the flow of fluid into the interior test chamber through the inlet port and the injection port and out of the interior test chamber through the outlet port.

Claim 2

Dependent Claim 130 words

A test vessel for an assay apparatus comprising an enclosed elongated body having an interior test chamber for receiving a test strip therein, an inlet port at one end of the body in fluid communication with said chamber with means to connect the port to an inlet manifold, an outlet port at the end of the body in fluid communication with said chamber opposite said inlet port with means to connect the outlet port to an outlet manifold, at least one injection port disposed between the inlet port and the outlet port in fluid communication with said chamber, and means to limit the flow of fluid into the interior test chamber through the inlet port and the injection port and out of the interior test chamber through the outlet port.

Claim 3

Dependent Claim 65 words

A test vessel according to claim 1 in which the means to control the flow comprises a check valve having flexible disk normally sealing off a port and means on the interior of said vessel bearing against the middle of said disk on the side of said disk opposite said port, whereby fluid pressure in said port bends said disk inward about said last-named means.

Claim 4

Dependent Claim 29 words

The vessel according to claim 1 having a plurality of injection ports spaced along the length of said test vessel and having separate check valves for each injection port.

Claim 5

Dependent Claim 26 words

The vessel according to claim 1 in which said inlet port includes a vertically-extending first nipple and the outlet port includes a vertically extending second nipple.

Claim 6

Dependent Claim 22 words

A test vessel according to claim 1 which includes a test paper impregnated with biological specimens along the bottom of said chamber.

Claim 7

Dependent Claim 24 words

The test vessel of claim 5 wherein the test paper is impregnated with biological specimens selected from the group consisting of antigens and antibodies.

Claim 8

Dependent Claim 11 words

The test vessel of claim 1 wherein the body is transparent.

Claim 9

Dependent Claim 14 words

The test vessel of claim 7 wherein the body has a rectangular transverse cross-section.

Claim 10

Dependent Claim 151 words

A multiple test chamber assay apparatus comprising (a) a plurality of enclosed elongated test vessels, each test vessel having an interior test chamber therein adapted to receive a test strip, an inlet port at one end thereof, a discharge port at the other end thereof, at least one injection port disposed between the inlet port and outlet port which is in fluid communication with the test chamber and means to limit the flow of fluid into the interior test chamber through the inlet port and the injection port out of the interior test chamber through the outlet port; (b) a common inlet manifold in fluid communication with inlet ports of the test vessels; (c) a common outlet manifold in fluid communication with outlet ports of the test vessels; (d) means to direct treatment fluids to the inlet manifold; and (e) means to support the test vessels in a generally parallel relationship.

Claim 11

Dependent Claim 151 words

A multiple test chamber assay apparatus comprising (a) a plurality of enclosed elongated test vessels, each test vessel having an interior test chamber therein adapted to receive a test strip, an inlet port at one end thereof, a discharge port at the other end thereof, at least one injection port disposed between the inlet port and outlet port which is in fluid communication with the test chamber and means to limit the flow of fluid into the interior test chamber through the inlet port and the injection port out of the interior test chamber through the outlet port; (b) a common inlet manifold in fluid communication with inlet ports of the test vessels; (c) a common outlet manifold in fluid communication with outlet ports of the test vessels; (d) means to direct treatment fluids to the inlet manifold; and (e) means to support the test vessels in a generally parallel relationship.

Claim 12

Dependent Claim 48 words

Apparatus according to claim 9 in which each of said test vessels are formed with at least one injection port spaced along the length of said test vessel having a check valve therein to allow fluid flow into the test chamber but prevent the discharge of fluid therefrom.

Claim 13

Dependent Claim 15 words

The assay apparatus of claim 9 wherein the fluid flow limiting means include check valves.

Claim 14

Dependent Claim 59 words

Apparatus according to claim 11 in which each of the check valves comprises a flexible disk normally sealing off said port and means on the interior of said vessel bearing against the middle of said disk on the side of said disk opposite said port, whereby fluid pressure in said port bends said disk inward about said last-named means.

Claim 15

Dependent Claim 21 words

The assay apparatus of claim 9 wherein the means to support the test vessels include a frame having parallel side rails.

Claim 16

Dependent Claim 25 words

The assay apparatus of claim 13 wherein the frame is adapted to pivot about an axis generally perpendicular to longitudinal axis of the test vessels.

Claim 17

Dependent Claim 18 words

The assay apparatus of claim 9 wherein the common inlet and outlet manifolds comprise an interfitting manifold segments.

Claim 18

Dependent Claim 61 words

The assay apparatus of claim 15 wherein the manifold segments include a male connection and a female connection, the male connection adapted to engage the female connection of an adjacent segment on one side of the test vessel and the female connection adapted to engage the male connection of an adjacent segment of a test vessel on the opposite side thereof.

Claim 19

Dependent Claim 57 words

The assay apparatus of claim 15 wherein each test vessel includes a pair of vertically extending nipples which depend from the test vessel, one of which cooperates with the inlet port to engage the inlet manifold segment in fluid communication and one which cooperates with the outlet port to engage the outlet manifold segment in fluid communication.

Claim 20

Dependent Claim 25 words

The assay apparatus of claim 17 wherein the inlet and outlet manifold segments are provided with vertical facing ports adapted to receive the depending nipples.

Claim 21

Dependent Claim 29 words

The assay apparatus of claim 15 wherein the manifold segements and provided with outwardly projecting tongues adapted to interfit recessed grooves provided within the side rails of the frame.

Claim 22

Dependent Claim 40 words

The assay apparatus of claim 19 including adjustable plug means slidably mounted on the side rails of the frame at one and thereof to seal open ends of the inlet and outlet manifold segments of a test vessel adjacent thereto.

Claim 23

Dependent Claim 38 words

The assay apparatus of claim 20 including fluid inlet and outlet conduits disposed on the end of the frame opposite the plug means adapted to engage the inlet and outlet manifold segments of a test vessel adjacent thereto.

Claim 24

Dependent Claim 30 words

The assay apparatus of claim 21 including means to urge the plug means and the inlet and outlet conduits together to fluidly interconnect with a plurality of test vessels therebetween.

Claim 25

Dependent Claim 35 words

The assay apparatus of claim 22 wherein the urging means includes an elongated threaded member interconnected with the means and means to rotate the threaded means to move the plug means longitudinally along the frame.

Claim 26

Dependent Claim 151 words

A multiple test vessel assay system comprising: (a) a plurality of test vessels, each test vessel having at least an inlet port and an outlet port in fluid communication with an interior test chamber therein adapted to receive a test strip; (b) means to limit the flow of fluid into the interior test chamber through the inlet port and out of the interior test chamber through the outlet port; (c) a common inlet manifold in fluid communication with the inlet ports of said test vessels; (d) a common outlet manifold in fluid communication with the outlet ports of said test vessels; (e) a plurality of conduits with each of the conduits in fluid communication with a separate fluid source and the common inlet manifold; and (f) automatically controlled valve means in said conduits to control the sequenceing of fluid flow from said sources into the common inlet manifold through said conduits.

Claim 27

Dependent Claim 151 words

A multiple test vessel assay system comprising: (a) a plurality of test vessels, each test vessel having at least an inlet port and an outlet port in fluid communication with an interior test chamber therein adapted to receive a test strip; (b) means to limit the flow of fluid into the interior test chamber through the inlet port and out of the interior test chamber through the outlet port; (c) a common inlet manifold in fluid communication with the inlet ports of said test vessels; (d) a common outlet manifold in fluid communication with the outlet ports of said test vessels; (e) a plurality of conduits with each of the conduits in fluid communication with a separate fluid source and the common inlet manifold; and (f) automatically controlled valve means in said conduits to control the sequenceing of fluid flow from said sources into the common inlet manifold through said conduits.

Claim 28

Dependent Claim 32 words

The assay system of claim 24 wherein the test vessels have injection ports in fluid communication with the interior test chamber with means to restrict flow therethrough into the interior test chamber.

Claim 29

Dependent Claim 19 words

The assay system of claim 24 including a frame for holding the test vessels in a generally parallel relationship.

Claim 30

Dependent Claim 35 words

The assay system of claim 24 including an electronic controller to automatically sequence the opening and closing of said valve means to provide a desired sequence of treatment fluids to each of said test vessels.

Claim 31

Dependent Claim 20 words

The assay system of claim 24 wherein the inlet and outlet manifolds comprise a plurality of individual interfitting manifold segments.

Annuity Stage	Window Opens	Payment Deadline	Surcharge Period Until	Estimated Fee	Status
3.5 Years (Year 4)	1992-08-21	1993-02-20	1993-08-22	$2000.00	Window Closed / Lapsed
7.5 Years (Year 8)	1996-08-21	1997-02-20	1997-08-22	$3760.00	Window Closed / Lapsed
11.5 Years (Year 12)	2000-08-21	2001-02-20	2001-08-22	$7700.00	Window Closed / Lapsed

Diagnostic manifold apparatus

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