US4857641A
Expired / Lapsed
US
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C.12 modified erythromycin A derivatives
Assignee: Pfizer Inc
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Filing: 1987-08-14
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Granted: 1989-08-15
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Expires: 2007-08-14
Abstract
Abstract Antibacterial 12,12'-anhydro-9R-hydroxy-9-deoxoerythromycin A derivatives, intermediate therefor and process of 12,12'-dehydration.
Inventors
- 👤 James R. Hauske
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 12:56
CPC Classifications
C; C07; C07H; C07H17/00; C07H17/04; C07H17/08; A; A61; A61P; A61P31/00; A61P31/04
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
99 words
A compound of the absolute stereochemical formula ##STR7## wherein R is hydrogen or (C 2 -C 4 ) alkanoyl; R 1 and R 2 are taken separately, R 1 is hydroxymethyl and R 2 is hydroxy; or R 1 and R 2 are taken together and are methylene; and R 3 and R 4 are taken separately and are each hydrogen; or R 3 and R 4 are taken together and are thiocarbonyl; with the proviso that when R 3 and R 4 are so taken, R is other than hydrogen; or a pharmaceutically acceptable acid addition salt thereof.
Claim 2
Dependent Claim
99 words
A compound of the absolute stereochemical formula ##STR7## wherein R is hydrogen or (C 2 -C 4 ) alkanoyl; R 1 and R 2 are taken separately, R 1 is hydroxymethyl and R 2 is hydroxy; or R 1 and R 2 are taken together and are methylene; and R 3 and R 4 are taken separately and are each hydrogen; or R 3 and R 4 are taken together and are thiocarbonyl; with the proviso that when R 3 and R 4 are so taken, R is other than hydrogen; or a pharmaceutically acceptable acid addition salt thereof.
Claim 3
Dependent Claim
9 words
A compound of claim 1 wherein R is acetyl.
Claim 4
Dependent Claim
17 words
A compound of claim 2 wherein R 1 and R 2 are taken together and are methylene.
Claim 5
Dependent Claim
17 words
The compound of claim 3 wherein R 3 and R 4 are taken together and are thiocarbonyl.
Claim 6
Dependent Claim
18 words
A compound of claim 2 wherein R 3 and R 4 are taken separately and are each hydrogen.
Claim 7
Dependent Claim
18 words
The compound of claim 3 wherein R 3 and R 4 are taken separately and are each hydrogen.
Claim 8
Dependent Claim
15 words
The compound of claim 5 wherein R 1 is hydroxymethyl and R 2 is hydroxy.
Claim 9
Dependent Claim
30 words
A compound of the absolute stereochemical formula ##STR8## wherein R 5 is (C 2 -C 4 ) alkanoyl or benzoyl; and R 6 is (C 2 -C 4 ) alkanoyl.
Claim 10
Dependent Claim
30 words
A compound of the absolute stereochemical formula ##STR8## wherein R 5 is (C 2 -C 4 ) alkanoyl or benzoyl; and R 6 is (C 2 -C 4 ) alkanoyl.
Claim 11
Dependent Claim
14 words
The compound of claim 8 wherein R 5 and R 6 are each acetyl.
Claim 12
Dependent Claim
15 words
The compound of claim 8 wherein R 5 is benzoyl and R 6 is acetyl.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1992-08-14 | 1993-02-13 | 1993-08-15 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1996-08-14 | 1997-02-13 | 1997-08-15 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2000-08-14 | 2001-02-13 | 2001-08-15 | $7700.00 | Window Closed / Lapsed |