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US4857334A Expired / Lapsed US ⏱️ 0.0 years remaining

Synthetic resin matrix system incorporating healing enhancer

Assignee: ENQUAY PHARMACEUTICAL ASSOCIATES A PARTNERSHIP
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Filing: 1988-05-27
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Granted: 1989-08-15
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Expires: 2008-05-27
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Abstract

Abstract An apparatus and method is described for applying epidermal growth factor (EGF) for achieving healing enhancement at a wound site. The human source of epidermal growth factor, designated as hEGF, is applied from the synthetic resin matrix system of this invention, and which comprises a polymer, such as poly(2-hydroxyl ethyl methyl methacrylate), referred to as PHEMA, an organic solvent, such as polyethylene glycol (PEG), and a hydrogen binding plasticizer, such as dimethylsulfoxide (DMSO). The plasticizer regulates the set-up time of the synthetic resin, so that the more plasticizer present, the shorter the set-up time. The dressing, once formed, and having the healing enhancer contained therein, may be sealed within various backing sheets, in order to preserve its aseptic condition. When ready for use, one of the backing sheets may be peeled away to expose the resin pad with the emobodied healing enhancer, ready for application to the wound site.

Inventors

  • 👤 Bernard Korol
  • 👤 Paul Nathan

Bibliographic Details

Application Number —
Jurisdiction US
Data Source google_patents
Last Synchronized 2026-11-02 15:27
CPC Classifications
A; A61; A61L; A61L26/00; A61L26/0061; A61L26/008; A61L15/00; A61L15/16; A61L15/22; A61L15/24; A61L15/42; A61L15/44; A61L26/0009; A61L26/0014; A61L2300/00; A61L2300/40; A61L2300/412; A61L2300/414; A61L2300/60; A61L2300/602

Claims Analysis

Total Claims: 7
Claim 1
Independent Claim 280 words
A synthetic resin matrix system for drug storage and extended duration drug release comprising a particulate, hydrophilic, water swellable polymer, and inert, non-toxic water miscible organic solvent, and a hydrogen bonding plasticizer; said polymer selected from the group consisting of a synthetic resin matrix system for drug storage and extended duration drug release comprising a particulate, hydrophilic, water swellable polymer, an inert, non-toxic water miscible organic solvent, and a hydrogen bonding plasticizer, said polymer selected from the group consisting of hydroxy(C 2 - 4 alkyl) methacrylate, hydroxy(C 2 - 4 alkyl) acrylate, hydroxy(C 2 - 4 alkoxyC 2 - 4 alkyl) methacrylate, hydroxy(C 2 - 4 alkoxyC 2 - $ alkyl) acrylate, alkoxy(C 2 - 4 alkoxyC 2 - 4 alkyl) methacrylate, alkoxy(C 2 - 4 alkoxyC 2 - 4 alkyl)acrylate, N-(C 1 - 4 alkyl) acrylamide, N-(C 1 - 4 alkyl) methacrylamide, N,N-di(C 1 - 4 alkyl) acrylamide, N,N-di(C 1 - 4 alkyl) methacrylamide, vicinal-epoxy(C 1 - 4 alkyl) methacrylate, or vicinal-epoxy(C 1 - 4 alkyl) acrylate, said solvent selected from the group consisting of polyethylene glycol or polypropylene glycol having a molecular weight averaging between about 200-2000 gram molecular weight units, and wherein said plasticizer being selected from the group consisting of dimethylsulfoxide, dimethylphthalate, 2,3-butylene carbonate, dimethylformamide, dimethyltetramethylene sulfone, diethylsulfone, methylene glycolate, methylpropyl sulfone, or butyrolactone, with said polymer ranging between about 15%-50% by weight of said matrix system, with said solvent ranging between about 30%-65% by weight of said matrix system, with said plasticizer ranging up to about 20% by weight of said matrix system, and further including a medicament agent for local or systemic therapeutic effects, said medicament agent being a growth factor or healing enhancer.
Claim 2
Dependent Claim 280 words
A synthetic resin matrix system for drug storage and extended duration drug release comprising a particulate, hydrophilic, water swellable polymer, and inert, non-toxic water miscible organic solvent, and a hydrogen bonding plasticizer; said polymer selected from the group consisting of a synthetic resin matrix system for drug storage and extended duration drug release comprising a particulate, hydrophilic, water swellable polymer, an inert, non-toxic water miscible organic solvent, and a hydrogen bonding plasticizer, said polymer selected from the group consisting of hydroxy(C 2 - 4 alkyl) methacrylate, hydroxy(C 2 - 4 alkyl) acrylate, hydroxy(C 2 - 4 alkoxyC 2 - 4 alkyl) methacrylate, hydroxy(C 2 - 4 alkoxyC 2 - $ alkyl) acrylate, alkoxy(C 2 - 4 alkoxyC 2 - 4 alkyl) methacrylate, alkoxy(C 2 - 4 alkoxyC 2 - 4 alkyl)acrylate, N-(C 1 - 4 alkyl) acrylamide, N-(C 1 - 4 alkyl) methacrylamide, N,N-di(C 1 - 4 alkyl) acrylamide, N,N-di(C 1 - 4 alkyl) methacrylamide, vicinal-epoxy(C 1 - 4 alkyl) methacrylate, or vicinal-epoxy(C 1 - 4 alkyl) acrylate, said solvent selected from the group consisting of polyethylene glycol or polypropylene glycol having a molecular weight averaging between about 200-2000 gram molecular weight units, and wherein said plasticizer being selected from the group consisting of dimethylsulfoxide, dimethylphthalate, 2,3-butylene carbonate, dimethylformamide, dimethyltetramethylene sulfone, diethylsulfone, methylene glycolate, methylpropyl sulfone, or butyrolactone, with said polymer ranging between about 15%-50% by weight of said matrix system, with said solvent ranging between about 30%-65% by weight of said matrix system, with said plasticizer ranging up to about 20% by weight of said matrix system, and further including a medicament agent for local or systemic therapeutic effects, said medicament agent being a growth factor or healing enhancer.
Claim 3
Dependent Claim 16 words
The invention of claim 1 and wherein said healing enhancer is an epidermal growth factor (EGF).
Claim 4
Dependent Claim 34 words
The invention of claim 2 and wherein said EGF is equivalent to human derived material (hEGF) comprising a polypeptide containing 53-amino acids and having a molecular weight of approximately 5,000 gram molecular weight units.
Claim 5
Dependent Claim 24 words
The invention of claim 3 and including a pair of backing sheets, and said matrix system with healing enhancer being arranged intermediate said sheets.
Claim 6
Dependent Claim 11 words
The invention of claim 4 and wherein said sheets being transparent.
Claim 7
Dependent Claim 14 words
The invention of claim 4 and wherein one of said backing sheets being elastic.

References Cited (Backward Citations)

US3287222A Cited
US3419006A Cited
US4191743A Cited
DE2725261A1 Cited
US4272518A Cited
EP0041934A1 Cited
US4347841A Cited

USPTO Annuity & Maintenance Windows

Annuity Stage Window Opens Payment Deadline Surcharge Period Until Estimated Fee Status
3.5 Years (Year 4) 1992-08-14 1993-02-13 1993-08-15 $2000.00 Window Closed / Lapsed
7.5 Years (Year 8) 1996-08-14 1997-02-13 1997-08-15 $3760.00 Window Closed / Lapsed
11.5 Years (Year 12) 2000-08-14 2001-02-13 2001-08-15 $7700.00 Window Closed / Lapsed

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