Process for implanting a medicament depot

Claim 3

A method of claim 1, wherein the gyrase inhibitor is a compound of the formula ##STR2## wherein X is N or CR 6 , Y is N or CR 8 , Z is N or CH, R 1 is alkyl, alkenyl, hydroxyalky, Hal-alkyl, NR 9 R 10 , OR 11 , cycloalkyl, Ar or Ar-alkyl, R 3 is H or alkyl, R 5 is H, Hal, alkyl or alkoxy, R 6 is H, Hal, alkyl, alkoxy or NO 2 , R 7 is alkyl, Hal, NR 9 R 10 , a 5- or 6-membered N-containing aromatic or aliphatic heterocycle, such as heterocycle containing an additional hetero O, N or S atom, or either of said heterocycles which is substituted, or R 6 and R 7 together form methylenedioxy, R 8 is H, Hal, alkyl or alkoxy or R 8 and R 1 together form --O--CH 2 --CHalkyl or --CH 2 CH 2 --CHalkyl, R 9 , R 10 and R 11 are each H or alkyl, Ar is phenyl or substituted phenyl, Hal is F, Cl, Br or I, and the alkyl, cycloalkyl, alkenyl and alkoxy groups in each case contain up to 6 C atoms.

Claim 4

A method of claim 2 wherein Y is N or CR 8 , Z is N or CH, R 1 is alkyl, Hal-alkyl, NH-alkyl, O-alkyl, cycloalkyl or Hal-phenyl, R 3 is H, R 5 is H, R 6 is H or Hal, R 7 is alkyl, Hal or a 5- or 6-membered N-containing aromatic or aliphatic heterocycle which optionally can contain a further N atom, each optionally substituted by one or two alkyl, amino or alkylaminoalkyl groups, or R 6 and R 7 together are methylenedioxy, R 8 is H, Hal or alkyl, or R 8 and R 1 together are --O--CH 2 --CHalkyl or --CH 2 CH 2 --CHalkyl and Hal is F or Cl and the alkyl groups in each case contain 1-3 C atoms.

Claim 5

The method of claim 2 wherein Y is N or CR 8 , Z is N or CH, R 1 is alkyl, 2-fluoroethyl, methylamino, methoxy, cyclopropyl or p-fluorophenyl, R 3 and R 5 are each H, R 6 is H or F, R 7 is methyl, Cl, pyrrl, pyrrolidino, 3,4-dimethylpyrrolidino, 3-aminopyrrolidino, 3-amino-4-methylpyrrolidino, 3-ethylaminomethyl-pyrrolidino, pyridyl, piperidyl, piperazino or 3- or 4-methylpiperazino, or R 6 and R 7 together are methylenedioxy and R 8 is H, methyl or F, or R 8 and R 1 together are --OCH 2 --CH(CH 3 )--or --CH 2 CH 2 --CH(CH 3 )--and the alkyl groups in each case contain 1-3 C atoms.

Claim 6

A method of claim 2 wherein Y is N or CR 8 Z is N or CH, R 1 is ethyl or cyclopropyl, R 3 and R 5 are each H, R 6 is F, R 7 is piperazino or 3- or 4-methylpiperazino, and R 8 is H, or R 8 and R 1 together are --O--CH 2 --CH(CH 3 ).

Claim 7

A method of claim 1 wherein the gyrase inhibitor is ciprofloxacin, ofloxacin, amifloxacin, cinoxacin, difloxacin (A-56619), enoxacin, flumequin, irloxacin, miloxacin, malidixic acid, norfloxacin, oxolic acid, pefloxacin, pipemidic acid, piromidic acid, rosoxacin, A-56620, A-57132, A-60969, A-656619, A-656620, AM-833, AT-3295, AT-3765, CI-934, E-3432, E-3499, EN-272, NY-198, OPC-7594, Ro-23-6240, S-25930, S-25932, T-14097, 79286-76-3, 80-107118, or 1-ethyl-2-phenyl-4-pyridone-5-carboxylic acid.

Claim 8

A method of claim 1 wherein the amount of active agent is 0.01 to 10%.

Claim 9

A method of claim 1 which is an implant.

Claim 10

A method of claim 1 wherein said depot is a bone cement or bone filler.

Claim 11

A method of claim 1 wherein the excipient comprises a polyacrylate or a polymethacrylate.

Claim 12

A method of claim 1 wherein the excipient is tricalcium phosphate.

Claim 13

A method of claim 1 wherein the excipient is collagen.

Claim 14

A method of claim 1 wherein the excipient is a polysaccharide or fibrin.