US4851382A
Expired / Lapsed
US
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Separation medium
Assignee: Mitsubishi Chemical Corp
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Filing: 1988-07-19
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Granted: 1989-07-25
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Expires: 2008-07-19
Abstract
Abstract A separation medium useful as an adsorbent of liquid chromatography for optical resolution of racemic mixtures is disclosed, which comprises a reversed phase support coated with an optically active amino acid derivative represented by formula (I): ##STR1## wherein R 1 represents a straight or branched alkyl group having from 1 to 3 carbon atoms; and R 2 and R 3 each represents a straight or branched alkyl group having from 4 to 12 carbon atoms which may contain an aromatic group or an unsaturated alkyl group. The separation medium is applicable to optical resolution of a wide range of DL-amino acids and exhibits excellent durability.
Inventors
- 👤 Hiroshi Kusano
- 👤 Hideaki Kiniwa
- 👤 Akihiro Shimura
- 👤 Masahiko Annaka
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-02 06:45
CPC Classifications
B; B01; B01J; B01J20/00; B01J20/281; B01J20/286; B01J20/287; B01J20/22; B01J20/223; B01J20/28; B01J20/28002; B01J20/28004; B01J20/28014; B01J20/28016; B01J20/28054; B01J20/28057; B01J20/28078; B01J20/29; B01J20/30; B01J20/3092; B01J20/32; B01J20/3202; B01J20/3204; B01J20/3231; B01J20/3242; B01J20/3244; B01J20/3246; B01J20/3257; B01J20/3259; B01J20/3261; B01J20/3263; B01J20/3265; C; C07; C07C; C07C227/00; C07C227/30; C07C227/34; B01J2220/00; B01J2220/50; B01J2220/52; B01J2220/54; B01J2220/58
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
78 words
A separation medium comprising a reversed phase support coated with an optically active amino acid derivative represented by formula (I): ##STR3## wherein R 1 represents a straight or branched alkyl group having from 1 to 3 carbon atoms; and R 2 and R 3 , which may be the same or different, each represents a straight or branched alkyl group having from 4 to 12 carbon atoms which may contain an aromatic group or an unsaturated alkyl group.
Claim 2
Dependent Claim
78 words
A separation medium comprising a reversed phase support coated with an optically active amino acid derivative represented by formula (I): ##STR3## wherein R 1 represents a straight or branched alkyl group having from 1 to 3 carbon atoms; and R 2 and R 3 , which may be the same or different, each represents a straight or branched alkyl group having from 4 to 12 carbon atoms which may contain an aromatic group or an unsaturated alkyl group.
Claim 3
Dependent Claim
34 words
A separation medium as claimed in claim 1, wherein the total number of carbon atoms contained in R 2 and R 3 is from 10 to 20 when R 1 contains one carbon atom.
Claim 4
Dependent Claim
36 words
A separation medium as claimed in claim 1, wherein the total number of carbon atoms contained in R 2 and R 3 is from 8 to 14 when R 1 contains 2 to 3 carbon atoms.
Claim 5
Dependent Claim
25 words
A separation medium as claimed in claim 1, wherein said support is a porous support having a particle size of from 1 to 50 μm.
Claim 6
Dependent Claim
34 words
A separation medium as claimed in claim 4, wherein said porous support has a pore diameter of from 10 to 1000 Å and a surface area of from 1 to 1000 m 2 .
Claim 7
Dependent Claim
28 words
A separation medium as claimed in claim 1, wherein said separation medium has an amino acid derivative coverage of from 1 to 50% by weight to the support.
Claim 8
Dependent Claim
28 words
A separation medium as claimed in claim 1, wherein said separation medium has an amino acid derivative coverage of from 5 to 30% by weight to the support.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1992-07-24 | 1993-01-23 | 1993-07-25 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1996-07-24 | 1997-01-23 | 1997-07-25 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2000-07-24 | 2001-01-23 | 2001-07-25 | $7700.00 | Window Closed / Lapsed |