US4847338A
Expired / Lapsed
US
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Low molecular weight heparin fragments as inhibitors of complement activation
Assignee: University of Iowa Research Foundation
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Filing: 1987-06-17
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Granted: 1989-07-11
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Expires: 2007-06-17
Abstract
Abstract There is disclosed a tetrasaccharide, a hexasaccharide, on octasaccharide and a decasaccharide all capable of inhibiting complement activation and having less tha 33% of undigested native heparin's anticoagulation activity.
Inventors
- 👤 Robert J. Linhardt
- 👤 Zohar M. Merchant
- 👤 John M. Weiler
- 👤 Murali Sharath
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-31 00:26
CPC Classifications
C; C07; C07H; C07H13/00; C07H13/12; C07H11/00; C08; C08B; C08B37/00; C08B37/006; C08B37/0063; C08B37/0075; C08B37/0078
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
63 words
A compound derived from depolymerized heparin comprising a free acid or metallic or non-metallic salt of a tetrasaccharide, a hexasaccharide, an octasaccharide, or a mixture thereof, wherein said compound has biological activity to inhibit complement activation, wherein said compound has diminished anticoagulant activity as compared to native heparin, and wherein the molecular weight of said compound is no greater than about 2300 daltons.
Claim 2
Dependent Claim
63 words
A compound derived from depolymerized heparin comprising a free acid or metallic or non-metallic salt of a tetrasaccharide, a hexasaccharide, an octasaccharide, or a mixture thereof, wherein said compound has biological activity to inhibit complement activation, wherein said compound has diminished anticoagulant activity as compared to native heparin, and wherein the molecular weight of said compound is no greater than about 2300 daltons.
Claim 3
Dependent Claim
14 words
The compound of claim 1 wherein said compound is obtained by heparinase EC-4.2.2.7 digestion.
Claim 4
Dependent Claim
11 words
The compound of claim 1 wherein the compound is a tetrasaccharide.
Claim 5
Dependent Claim
12 words
The compound of claim 3 wherein the tetrasaccharide is a hexasulfated tetrasaccharide.
Claim 6
Dependent Claim
11 words
The compound of claim 1 wherein the compound is a hexasaccharide.
Claim 7
Dependent Claim
11 words
The compound of claim 1 wherein the compound is an octasaccharide.
Claim 8
Dependent Claim
37 words
A compound derived from depolymerized heparin, comprising a free acid or metallic or non-metallic salt of a decasaccharide, said compound has biological activity to inhibit complement activation and has diminished anticoagulant activity as compared to native heparin.
Claim 9
Dependent Claim
37 words
A compound derived from depolymerized heparin, comprising a free acid or metallic or non-metallic salt of a decasaccharide, said compound has biological activity to inhibit complement activation and has diminished anticoagulant activity as compared to native heparin.
Claim 10
Dependent Claim
18 words
A method of treating immune disorders in mammals, comprising the intravenous administration of the decasaccharide of claim 7.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1992-07-10 | 1993-01-09 | 1993-07-11 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1996-07-10 | 1997-01-09 | 1997-07-11 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2000-07-10 | 2001-01-09 | 2001-07-11 | $7700.00 | Window Closed / Lapsed |