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US4847296A
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Triglyceride preparations for the prevention of catabolism
Assignee: Individual
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Filing: 1987-03-20
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Granted: 1989-07-11
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Expires: 2007-03-20
Abstract
Abstract Chemically synthesized structured triglycerides (lipids) for enteral administration as the lipid calorie source, is subjects undergoing severe metabolic stress.
Inventors
- 👤 Vigen K. Babayan
- 👤 George L. Blackburn
- 👤 Bruce R. Bistrian
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 07:44
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/21; A61K31/215; A61K31/22; A61K31/23
Claims Analysis
Total Claims: 15
Claim 1
Independent Claim
100 words
A method of preventing catabolism and increasing protein synthesis in a subject undergoing metabolic stress, which comprises administering enterally to the subject from about 0.3 gms of fat/Kg of body weight/day to about 4.0 gms of fat/Kg of body weight/day of a synthetic structured lipid of the formula ##STR2## wherein R 1 and R 2 may be independently a C 6 to C 24 acid provided that one of R 1 , R 2 or R 3 is a C 12 acid, and one of R 1 , R 2 and R 3 is omega 6 or omega 3 acid.
Claim 2
Independent Claim
100 words
A method of preventing catabolism and increasing protein synthesis in a subject undergoing metabolic stress, which comprises administering enterally to the subject from about 0.3 gms of fat/Kg of body weight/day to about 4.0 gms of fat/Kg of body weight/day of a synthetic structured lipid of the formula ##STR2## wherein R 1 and R 2 may be independently a C 6 to C 24 acid provided that one of R 1 , R 2 or R 3 is a C 12 acid, and one of R 1 , R 2 and R 3 is omega 6 or omega 3 acid.
Claim 3
Dependent Claim
55 words
The method according to claim 1 wherein the synthetic structured lipid is a rearranged mixture of a kernel type oil rich in fatty acids C 6 -C 12 and long chain triglycerides (LCT) oils having a percent composition of MCT to LCT 70 to 30%, 80 to 20%, 85 to 15% or 90 to 10%.
Claim 4
Dependent Claim
22 words
The method according to claim 2 wherein the percent composition of MCT to LCT is 80 to 20% or 85 to 15%.
Claim 5
Dependent Claim
32 words
The method according to claim 2 wherein the structured lipid comprises a medium chain triglyceride having a high lauric acid content and the long chain triglyceride has a high polyunsaturated acid content.
Claim 6
Dependent Claim
48 words
The method according to claim 4 wherein the medium chain triglyceride oils are babassu oil, coconut oil, cohune oil, palm kernel oil, tucum oil, and fractions thereof, and the long chain triglyceride oils are corn oil, peanut oil, safflower oil, soybean oil, sunflower seed oil and fish oil.
Claim 7
Dependent Claim
21 words
The method according to claim 5 wherein the structured lipid is prepared from a fractionated palm kernel oil and soybean oil.
Claim 8
Dependent Claim
23 words
The method according to claim 5 wherein the structured lipid is prepared from a mixture of 80% coconut oil and 20% soybean oil.
Claim 9
Dependent Claim
79 words
A pharmaceutical composition for enteral administration in preventing catabolism and increasing protein synthesis in a subject undergoing metabolic stress which comprises a structured lipid of the formula ##STR3## wherein R 1 and R 2 may be independently a C 6 to C 24 acid provided that one of R 1 , R 2 or R 3 is a C 12 acid, and one of R 1 , R 2 and R 3 is omega 6 or omega 3 acid.
Claim 10
Dependent Claim
79 words
A pharmaceutical composition for enteral administration in preventing catabolism and increasing protein synthesis in a subject undergoing metabolic stress which comprises a structured lipid of the formula ##STR3## wherein R 1 and R 2 may be independently a C 6 to C 24 acid provided that one of R 1 , R 2 or R 3 is a C 12 acid, and one of R 1 , R 2 and R 3 is omega 6 or omega 3 acid.
Claim 11
Dependent Claim
37 words
The pharmaceutical composition according to claim 8 wherein the structured lipid is prepared from a medium chain triglyceride oil having a high lauric acid content and a long chain triglyceride oil having a high polyunsaturated acid content.
Claim 12
Dependent Claim
49 words
The pharmaceutical composition according to claim 8 wherein the medium chain triglyceride oils are babassu oil, coconut oil, cohune oil, palm kernel oil, tucum oil, and fractions thereof, and the long chain triglyceride oils and corn oil, peanut oil, safflower oil, soybean oil, sunflower seed oil and fish oil.
Claim 13
Dependent Claim
22 words
The pharmaceutical composition according to claim 10 wherein the structured lipid is prepared from a fractionated palm kernel oil and soybean oil.
Claim 14
Dependent Claim
24 words
The pharmaceutical composition according to claim 10 wherein the structured lipid is prepared from a mixture of 80% coconut oil and 20% soybean oil.
Claim 15
Dependent Claim
23 words
The pharmaceutical composition according to claim 12 containing amino acids, vitamins and minerals in amounts effective for the treatment of the stressed subject.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1992-07-10 | 1993-01-09 | 1993-07-11 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1996-07-10 | 1997-01-09 | 1997-07-11 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2000-07-10 | 2001-01-09 | 2001-07-11 | $7700.00 | Window Closed / Lapsed |