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US4847080A
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US
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Pre-S gene coded peptide hepatitis B immunogens, vaccines, diagnostics, and synthetic lipide vesicle carriers
Assignee: California Institute of Technology
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Filing: 1985-02-05
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Granted: 1989-07-11
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Expires: 2005-02-05
Abstract
Abstract A hepatitis B vaccine containing a peptide with an amino acid chain of at least six consecutive amino acids within the pre-S gene coded region of the envelope of hepatitis B virus. The vaccine being free of an amino acid sequence corresponding to the naturally occurring envelope proteins of hepatitis B virus and a physiologically acceptable diluent. The peptide being free or linked to a carrier. The carrier being a conventional carrier or a novel carrier including a lipid vesicle stabilized by cross-linking and having covalently bonded active sites on the outer surface thereon. Such novel carrier being useful not only to link the novel peptide containing an amino acid chain with amino acids within the pre-S gene coded region of the surface antigen of hepatitis B virus, but can also be used to bind synthetic peptide analogues of other viral proteins, as well as bacterial, allergen and parasitic proteins of man and animals. The peptides of the invention can be utilized in diagnostics for the detection of antigens and antibodies.V
Inventors
- 👤 Alexander R. Neurath
- 👤 Stephen B. H. Kent
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 18:56
CPC Classifications
C; C07; C07K; C07K14/00; C07K14/005; C12; C12N; C12N15/00; A; A61; A61K; A61K39/00; A61K39/12; A61K39/29; A61K47/00; A61K47/50; A61K47/51; A61K47/56; A61K47/58; A61K47/62; A61K47/64; A61K47/645; A61K47/69; A61K47/6905; A61K47/6911; A61K9/00; A61K9/10; A61K9/127; A61K9/1271; C07K16/00; C07K16/08; C07K16/081; C07K16/082; C07K7/00; C07K7/04; G; G01; G01N; G01N33/00; G01N33/48; G01N33/50; G01N33/53; G01N33/576; G01N33/5761; G01N33/5764; C12N2730/00; C12N2730/00011; C12N2730/10011; C12N2730/10111; C12N2730/10122; Y; Y02; Y02A; Y02A50/00; Y02A50/30; Y10; Y10S; Y10S930/00; Y10S930/01; Y10S930/22; Y10S930/221; Y10S930/222; Y10S930/223; Y10S930/26; Y10S930/27
Claims Analysis
Total Claims: 44
Claim 1
Independent Claim
42 words
A hepatitis B peptide comprising an amino acid chain of at least six consecutive amino acids within the pre-S gene coded region of the envelope of hepatitis B virus, said peptide not comprising a naturally occurring envelope protein of hepatitis B virus.
Claim 2
Dependent Claim
42 words
A hepatitis B peptide comprising an amino acid chain of at least six consecutive amino acids within the pre-S gene coded region of the envelope of hepatitis B virus, said peptide not comprising a naturally occurring envelope protein of hepatitis B virus.
Claim 3
Dependent Claim
24 words
A hepatitis B peptide according to claim 1, wherein said chain of amino acids is located within sequence position pre-S 120 to pre-S 174.
Claim 4
Dependent Claim
22 words
A hepatitis B peptide according to claim 2, wherein said chain of amino acids comprises N-terminal methionine at sequence position pre-S 120.
Claim 5
Dependent Claim
24 words
A hepatitis B peptide according to claim 1, wherein said chain of amino acids is located within sequence position pe-S 1 to pre-S 120.
Claim 6
Dependent Claim
20 words
A hepatitis B peptide according to claim 1, wherein said peptide contains a chain of at least 10 amino acids.
Claim 7
Dependent Claim
20 words
A hepatitis B peptide according to claim 1, wherein said peptide contains a chain of at least 15 amino acids.
Claim 8
Dependent Claim
20 words
A hepatitis B peptide according to claim 1, wherein said peptide contains a chain of at least 20 amino acids.
Claim 9
Dependent Claim
20 words
A hepatitis B peptide according to claim 1, wherein said peptide contains a chain of at least 26 amino acids.
Claim 10
Dependent Claim
21 words
A hepatitis B peptide according to claim 1, wherein said chain is located within sequence positions pre-S 15 to pre-S 120.
Claim 11
Dependent Claim
21 words
A hepatitis B peptide according to claim 1, wherein said chain is located within sequence position pre-S 15 to pre-S 55.
Claim 12
Dependent Claim
21 words
A hepatitis B peptide according to claim 1, wherein said chain is located within sequence position pre-S 90 to pre-S 120.
Claim 13
Dependent Claim
21 words
A hepatitis B peptide according to claim 1, wherein said chain is located within sequence position pre-S 10 and pre-S 40.
Claim 14
Dependent Claim
23 words
A hepatitis B peptide according to claim 1, wherein said chain comprises to amino acids in the ayw subtype of the pre-S region.
Claim 15
Dependent Claim
23 words
A hepatitis B peptide according to claim 1, wherein said chain comprises to amino acids in the adyw subtype of the pre-S region.
Claim 16
Dependent Claim
23 words
A hepatitis B peptide according to claim 1, wherein said chain comprises to amino acids in the ayw2 subtype of the pre-S region.
Claim 17
Dependent Claim
23 words
A hepatitis B peptide according to claim 1, wherein said chain comprises to amino acids in the adw subype of the pre-S region.
Claim 18
Dependent Claim
23 words
A hepatitis B peptide according to claim 1, wherein said chain comprises to amino acids in the adr subtype of the pre-S region.
Claim 19
Dependent Claim
13 words
A heptatis B peptide according to claim 1, wherein said chain is MQWNSTAFHQTLQDPRVRGLYLPAGG.
Claim 20
Dependent Claim
13 words
A hepatitis B peptide according to claim 1, wherein said chain is MGTNLSVPNPLGFFPDHQLDP.
Claim 21
Dependent Claim
13 words
A hepatitis B peptide according to claim 1, wherein said chain is PAFGANSNNPDWFNPVKDDWP.
Claim 22
Dependent Claim
13 words
A hepatitis B peptide according to claim 1, wherein said chain is PQAMQWNSTAFHQTLQDP.
Claim 23
Dependent Claim
13 words
A hepatitis B peptide according to claim 1, wherein said chain is PASTNRQSGRQPTPISPPLRDSHP.
Claim 24
Dependent Claim
13 words
A hepatitis B peptide according to claim 1, wherein said chain is PAPNIASHISSISARTGDP.
Claim 25
Dependent Claim
13 words
A hepatitis B peptide according to claim 1, wherein said chain is MGGWSSKPRKGMGTNLSVPNP.
Claim 26
Dependent Claim
13 words
A hepatitis B peptide according to claim 1, wherein said chain is PAFGANSNNPDWDFNPVKDDWP.
Claim 27
Dependent Claim
13 words
A hepatitis B peptide according to claim 1, wherein said chain is QVGVGAFGPRLTPPHGG.
Claim 28
Dependent Claim
13 words
A hepatitis B peptide according to claim 1, wherein said chain is MGGWSSKPRKG.
Claim 29
Dependent Claim
13 words
A hepatitis B peptide according to claim 1, wherein said chain is MGGWSSKPRQG.
Claim 30
Dependent Claim
34 words
A hepatitis B peptide according to claim 1, wherein said peptide does not comprise an amino acid sequence comprising the entire S gene coded region of the envelope gene product of hepatitis B virus.
Claim 31
Dependent Claim
18 words
A hepatitis B peptide according to claim 1, wherein said peptide has no more than 100 amino acids.
Claim 32
Dependent Claim
18 words
A hepatitis B peptide according to claim 1, wherein said peptide has no more than 40 amino acids.
Claim 33
Dependent Claim
18 words
A hepatitis B peptide according to claim 1, wherein said peptide has no more than 30 amino acids.
Claim 34
Dependent Claim
16 words
A hepatitis B peptide according to claim 1, wherein said peptide is linked to a carrier.
Claim 35
Dependent Claim
17 words
A hepatitis B peptide according to claim 33, wherein said peptide is covalently linked to a carrier.
Claim 36
Dependent Claim
19 words
A hepatitis B peptide according to claim 34, wherein said peptide is covalently linked to a lipid vesicle carrier.
Claim 37
Dependent Claim
16 words
A hepatitis B peptide according to claim 35, wherein said lipid vesicle is stabilized by cross-linking.
Claim 38
Dependent Claim
13 words
A hepatitis B peptide according to claim 1, wherein said chain is pre-S(120-145).
Claim 39
Dependent Claim
13 words
A hepatitis B peptide according to claim 1, wherein said chain is pre-S(12-32)
Claim 40
Dependent Claim
13 words
A hepatitis B peptide according to claim 1, wherein said chain is pre-S(117-134).
Claim 41
Dependent Claim
13 words
A hepatitis B peptide according to claim 1, wherein said chain is pre-S(94-117).
Claim 42
Dependent Claim
13 words
A hepatitis B peptide according to claim 1, wherein said chain is pre-S(153-171).
Claim 43
Dependent Claim
13 words
A hepatitis B peptide according to claim 1, wherein said chain is pre-S(1-21).
Claim 44
Dependent Claim
13 words
A hepatitis B peptide according to claim 1, wherein said chain is pre-S(57-73).
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1992-07-10 | 1993-01-09 | 1993-07-11 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1996-07-10 | 1997-01-09 | 1997-07-11 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2000-07-10 | 2001-01-09 | 2001-07-11 | $7700.00 | Window Closed / Lapsed |