Patent US4843158A successfully refreshed from Google Patents.
US4843158A
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[2,2,1]Cryptand compounds that selectively bind sodium
Assignee: GE Healthcare Ltd
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Filing: 1986-11-19
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Granted: 1989-06-27
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Expires: 2006-11-19
Abstract
Abstract A compound having the property of selectively binding sodium ions in the presence of potassium ions and having the formula: <IMAGE> where X is <IMAGE> and where any aromatic ring may be substituted and/or may form part of a fused aromatic ring system. At least one of the aromatic rings may be substituted by a spectroscopic reporter group, a group which permits the compound to enter and remain in a cell and/or an electron donating or withdrawing group. A method of determining cytoplasmic sodium concentration by using this compound as a probe is also described.
Inventors
- 👤 Gerald A. Smith
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 21:29
CPC Classifications
C; C07; C07D; C07D498/00; C07D498/02; C07D498/08; G; G01; G01N; G01N33/00; G01N33/48; G01N33/50; G01N33/84
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
57 words
A compound having the property of selectively binding sodium ions in the presence of potassium ions and having the formula: ##STR7## where X is: ##STR8## and Y is --OEt or --OH and where any or all of the aromatic rings may carry substituents at any free position and/or may form part of a fused aromatic ring system.
Claim 2
Dependent Claim
57 words
A compound having the property of selectively binding sodium ions in the presence of potassium ions and having the formula: ##STR7## where X is: ##STR8## and Y is --OEt or --OH and where any or all of the aromatic rings may carry substituents at any free position and/or may form part of a fused aromatic ring system.
Claim 3
Dependent Claim
20 words
A compound as claimed in claim 1, wherein at least one aromatic ring is substituted by a spectroscopic reporter group.
Claim 4
Dependent Claim
29 words
A compound as claimed in claim 2, wherein at least one aromatic ring is substituted by a group which permits the compound to enter and remain in a cell.
Claim 5
Dependent Claim
18 words
A compound as claimed in claim 3, wherein the group is an acetoxymethyl ester of an anilinodiacetic acid.
Claim 6
Dependent Claim
22 words
A compound as claimed in claim 1, wherein at least one aromatic ring is substituted by an electron donating or withdrawing group.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1992-06-26 | 1992-12-26 | 1993-06-27 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1996-06-26 | 1996-12-26 | 1997-06-27 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2000-06-26 | 2000-12-26 | 2001-06-27 | $7700.00 | Window Closed / Lapsed |