Patent US2574342A successfully refreshed from Google Patents.
Patent US4842575A successfully refreshed from Google Patents.
US4842575A
Expired / Lapsed
US
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Method for forming impregnated synthetic vascular grafts
Assignee: Boston Scientific Scimed Inc
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Filing: 1988-08-05
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Granted: 1989-06-27
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Expires: 2008-08-05
Abstract
Abstract A collagen impregnated synthetic vascular graft including a synthetic vascular graft substrate and cross-linked collagen fibril is formed by depositing an aqueous slurry of collagen fibrils in the lumen of the graft and massaging to insure intimate mixing of the fibrils into the porous structure of the substrate. After massaging, the collagen is dried and cross-linked. Repeated applications and massaging and drying further reduce porosity of the graft.
Inventors
- 👤 Harmon Hoffman, Jr.
- 👤 Kemal Schankereli
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 12:58
CPC Classifications
A; A61; A61L; A61L27/00; A61L27/50; A61L27/507; A61F; A61F2/00; A61F2/02; A61F2/04; A61F2/06; A61L27/28; A61L27/34; A61L27/502; A61F2002/065; Y; Y10; Y10S; Y10S128/00; Y10S128/08; Y10S623/00; Y10S623/92; Y10S623/921
Claims Analysis
Total Claims: 18
Claim 1
Independent Claim
74 words
A process for preparing a blood-tight collagen-impregnated synthetic vascular graft, comprising: providing a porous tubular flexible synthetic graft substrate; placing an aqueous slurry of water-insoluble collagen fibrils and plasticizer onto at least the inner surface of the substrate; massaging the substrate to insure intimate mixing of the collagen fibrils into the porous structure of the substrate; drying the collagen; cross-linking the collagen by exposure to formaldehyde vapor; and vacuum drying to remove excess formaldehyde.
Claim 2
Dependent Claim
74 words
A process for preparing a blood-tight collagen-impregnated synthetic vascular graft, comprising: providing a porous tubular flexible synthetic graft substrate; placing an aqueous slurry of water-insoluble collagen fibrils and plasticizer onto at least the inner surface of the substrate; massaging the substrate to insure intimate mixing of the collagen fibrils into the porous structure of the substrate; drying the collagen; cross-linking the collagen by exposure to formaldehyde vapor; and vacuum drying to remove excess formaldehyde.
Claim 3
Dependent Claim
32 words
A collagen fibril slurry for forming a blood-tight synthetic vascular graft comprising about 0.5 to 5.0 percent collagen fibril, 4.0 to 12.0 percent of a biologically compatible plasticizer and the balance water.
Claim 4
Dependent Claim
32 words
A collagen fibril slurry for forming a blood-tight synthetic vascular graft comprising about 0.5 to 5.0 percent collagen fibril, 4.0 to 12.0 percent of a biologically compatible plasticizer and the balance water.
Claim 5
Dependent Claim
17 words
The slurry of claim 2, wherein the collagen fibrils are obtained by acid digestion of bovine skin.
Claim 6
Dependent Claim
18 words
The slurry of claim 2, wherein the plasticizer is selected from the group consisting of sorbitol and glycerine.
Claim 7
Dependent Claim
23 words
The process of claim 1, wherein the slurry is applied and massaged through the substrate at least three times and dried between applications.
Claim 8
Dependent Claim
75 words
A process for preparing a blood-type collagen-impregnated synthetic vascular graft, comprising: providing a porous tubular flexible synthetic graft substrate; placing a aqueous slurry of water-insoluble collagen fibrils and plasticizer onto the inner surface of the substrate; massaging the substrate to mature intimate mixing of the collagen fibrils into the porous structure of the substrate; drying the collagen; cross-linking the collagen by exposure to a biocompatible cross-linking agent; and vacuum drying to remove excess cross-linking agent.
Claim 9
Dependent Claim
75 words
A process for preparing a blood-type collagen-impregnated synthetic vascular graft, comprising: providing a porous tubular flexible synthetic graft substrate; placing a aqueous slurry of water-insoluble collagen fibrils and plasticizer onto the inner surface of the substrate; massaging the substrate to mature intimate mixing of the collagen fibrils into the porous structure of the substrate; drying the collagen; cross-linking the collagen by exposure to a biocompatible cross-linking agent; and vacuum drying to remove excess cross-linking agent.
Claim 10
Dependent Claim
24 words
The process of claim 6, wherein the substrate has a porosity of less than about 3,000 ml/min.-cm 2 (purified water at 120 mm Hg);
Claim 11
Dependent Claim
12 words
The process of claim 6, wherein the cross-linking agent is formaldehyde vapor.
Claim 12
Dependent Claim
12 words
The process of claim 7, wherein the cross-linking agent is formaldehyde vapor.
Claim 13
Dependent Claim
20 words
The process of claim 6, wherein the slurry is applied in at least three applications and dried between each application.
Claim 14
Dependent Claim
20 words
The process of claim 7, wherein the slurry is applied in at least three applications and dried between each application.
Claim 15
Dependent Claim
20 words
The process of claim 6, wherein the aqueous slurry contains between about 0.5 to 5.0 weight percent water-insoluble collagen fibrils.
Claim 16
Dependent Claim
20 words
The process of claim 7, wherein the aqueous slurry contains between about 0.5 to 5.0 weight percent water-insoluble collagen fibrils.
Claim 17
Dependent Claim
20 words
The process of claim 12, wherein the platicizer is present in an amount between about 4 to 12 weight percent.
Claim 18
Dependent Claim
20 words
The process of claim 13, wherein the plasticizer is present in an amount between about 4 to 12 weight percent.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1992-06-26 | 1992-12-26 | 1993-06-27 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1996-06-26 | 1996-12-26 | 1997-06-27 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2000-06-26 | 2000-12-26 | 2001-06-27 | $7700.00 | Window Closed / Lapsed |