US4840799A
Expired / Lapsed
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Process for preparing rapidly disintegrating granulates
Assignee: Lejus Medical AB
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Filing: 1987-02-17
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Granted: 1989-06-20
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Expires: 2007-02-17
Abstract
Abstract The present invention relates to a process for preparing a rapidly disintegrating core granulate containing a pharmaceutically active compound, which granulate is optionally intended to be coated with a release determining coating, as well as such cores, whereby one adds a pharmaceutically active compound, optionally together with an emulsifier, to a solvent, and optionally treats the composition obtained intensively, optionally while reducing its particle size, distributes the treated composition obtained over a bed of a solid, preferably water soluble material, and dries the agglomerates thus obtained to the so as to form a rapidly disintegrating core granulate.
Inventors
- 👤 Curt H. Appelgren
- 👤 Eva C. Eskilsson
- 👤 Jonas P. Uvdal
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-29 09:30
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/14; A61K9/16; A61K9/167; A61K9/1676; A61K9/1682; A61K9/1694
Claims Analysis
Total Claims: 21
Claim 1
Independent Claim
133 words
A process for the preparation of a rapidly disintegrating core comprising a pharmaceutically active compound, said process comprising adding an emulsifier/tenside having a HLB-value corresponding to the solubility characteristics of the pharmaceutically active compound in a solution or a suspension of the pharmaceutically active compound in a water:alcohol mixture having a weight ratio of 40-80:60-20 to form a pumpable composition, subjecting the pumpable composition to an intense treatment in an apparatus selected from the group of homogenizer, colloid mill, pearl mill, and pebble mill wherein the composition is distributed over a bed of at least one solid material having a large effective surface area and having nonbinding properties to the said pharmaceutically active compound so as to form an agglomerate, and drying the agglomerate to form a granulate having irregular or spherical form.
Claim 2
Dependent Claim
133 words
A process for the preparation of a rapidly disintegrating core comprising a pharmaceutically active compound, said process comprising adding an emulsifier/tenside having a HLB-value corresponding to the solubility characteristics of the pharmaceutically active compound in a solution or a suspension of the pharmaceutically active compound in a water:alcohol mixture having a weight ratio of 40-80:60-20 to form a pumpable composition, subjecting the pumpable composition to an intense treatment in an apparatus selected from the group of homogenizer, colloid mill, pearl mill, and pebble mill wherein the composition is distributed over a bed of at least one solid material having a large effective surface area and having nonbinding properties to the said pharmaceutically active compound so as to form an agglomerate, and drying the agglomerate to form a granulate having irregular or spherical form.
Claim 3
Dependent Claim
31 words
A process according to claim 1, wherein microcrystalline cellulose is part of the material in said bed and is present in an amount so as to form 2-25% of the granulate.
Claim 4
Dependent Claim
32 words
A process according to claim 1, wherein a disintegrating agent is part of the material in said bed and is present in an amount so as to form 2-25% of the granulate.
Claim 5
Dependent Claim
34 words
A process according to claim 1, wherein the pharmaceutically active compound has a solubility of less than 1000 mg per liter and is present in an amount of up to 50% of the granulate.
Claim 6
Dependent Claim
32 words
A process according to claim 4, wherein the pharmaceutically active compound is selected from the group consisting of nifedipine, nimodipine, nivadipine, nitrendipine, nisoldipine, niludipine, nicardipine, felodipine, omeprazole, spironolactone, griseofulvine, furosemide, and terbutaline.
Claim 7
Dependent Claim
33 words
A process according to claim 1, wherein the pharmaceutically active compound has a solubility of 1 to 10 grams per liter, and has an absorption window at the absorption in the gastrointestinal tract.
Claim 8
Dependent Claim
23 words
A process according to claim 6, wherein the pharmaceutically active compound is selected from the group consisting of L-dopa, riboflavin, digoxin, and digitoxin.
Claim 9
Dependent Claim
50 words
A process according to claim 1, wherein the emulsifier having a corresponding HLB-value is selected from the group consisting of polyoxyethylene sorbitan fatty acid esters, polyoxystearate, and polyethylene glycol, and whereby the emulsifier is added in an amount of 5 to 100% of the weight of the pharmaceutically active compound.
Claim 10
Dependent Claim
33 words
A process according to claim 8, wherein the emulsifier is selected from the group consisting of sodium laurylsulphate, polyoxyethylene-polyoxypropylene copolymer, ester of polyhydroxyalcohols, macrogel esters, macrogel ethers, long chain alcohols, and macrogel-polyoxypropylene copolymer.
Claim 11
Dependent Claim
49 words
A process according to claim 1, wherein the bed is at least one solid material selected from the group consisting of mannitol, lactose, saccharose, glucose, fructose, sorbitol, xylitol, sodium phosphate, potassium phosphate, urea, citrate, and ascorbic acid wherein said material comprises at least 40% by weight of the granulate.
Claim 12
Dependent Claim
19 words
A process according to claim 10, wherein the solid material comprises 60 to 90% by weight of the granulate.
Claim 13
Dependent Claim
23 words
A process according to claim 1, wherein the solid material is selected from the group consisting of starch, calcium phosphate, and calcium citrates.
Claim 14
Dependent Claim
34 words
A process according to claim 3, wherein the disintegrating agent is selected from the group consisting of substituted hydroxypropylcellulose, carboxymethylstarch, cross-linked carboxymethylcellulose, cross-linked starch, and cross-linked polyvinylpyrrolidone in an amount of 2-15% by weight.
Claim 15
Dependent Claim
18 words
A process according to claim 1, wherein the granulate has a disintegration time of 5 to 10 minutes.
Claim 16
Dependent Claim
22 words
A process according to claim 1, wherein the solid material in the bed has a particle size of less than 500 microns.
Claim 17
Dependent Claim
15 words
A process according to claim 15, wherein said particle size is less than 250 microns.
Claim 18
Dependent Claim
22 words
A process according to claim 10, wherein the solid material in the bed has a particle size of less than 500 microns.
Claim 19
Dependent Claim
22 words
A process according to claim 11, wherein the solid material in the bed has a particle size of less than 500 microns.
Claim 20
Dependent Claim
22 words
A process according to claim 12, wherein the solid material in the bed has a particle size of less than 500 microns.
Claim 21
Dependent Claim
33 words
A process according to claim 1, wherein the emulsifier is selected from the group consisting of sodium laurylsulphate, polyoxyethylene-polyoxypropylene copolymer, ester of polyhydroxyalcohols, macrogel esters, macrogel ethers, long chain alcohols, and macrogel-polyoxypropylene copolymer.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1992-06-19 | 1992-12-19 | 1993-06-20 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1996-06-19 | 1996-12-19 | 1997-06-20 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2000-06-19 | 2000-12-19 | 2001-06-20 | $7700.00 | Window Closed / Lapsed |