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US4839467A
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Radioactive rhenium complexed to 2-hydroxy isobutyric acid
Assignee: CINCINNATI A CORP OF OH, University of
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Filing: 1988-06-15
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Granted: 1989-06-13
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Expires: 2008-06-15
Abstract
Abstract A composition of matter having the following general formula ##STR1## wherein L represents 2-hydroxy isobutyric acid. This composition of matter is useful in improving the reaction efficiency or yield when bonding rhenium to a chelating ligand preferably a polydentate sulfur, selenium, phosphorous or nitrogen ligand. This provides a method to bond radioactive rhenium to various chelating ligands for a radiopharmaceutical. Further, this also provides a method to bond a radioactive rhenium to a protein such as a monoclonal antibody. This in turn provides a method to provide beta emitting radiation to cancer cells.
Inventors
- 👤 Edward A. Deutsch
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 14:26
CPC Classifications
A; A61; A61K; A61K51/00; A61K51/02; A61K51/04; A61K51/0474; A61K51/0476; A61K51/0478; C; C07; C07C; C07C51/00; C07C51/41; C07C51/418; C07C59/00; C07C59/01; C07F; C07F13/00; C07F13/005; G; G01; G01N; G01N33/00; G01N33/48; G01N33/50; G01N33/58; G01N33/60; A61K2123/00
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
15 words
Rhenium selected from the group consisting of rhenium-186 and rhenium-188 complexed to 2-hydroxy isobutyric acid.
Claim 2
Dependent Claim
15 words
Rhenium selected from the group consisting of rhenium-186 and rhenium-188 complexed to 2-hydroxy isobutyric acid.
Claim 3
Dependent Claim
29 words
The complex claimed in claim 1 wherein said complex has the following general formula (O)Re(V)(L).sub.4.sup.- X.sup.+ wherein L represents 2-hydroxy isobutyric acid and X is a pharmaceutically acceptable cation.
Claim 4
Dependent Claim
11 words
The complex claimed in claim 2 wherein said rhenium is rhenium-188.
Claim 5
Dependent Claim
11 words
The complex claimed in claim 2 wherein said rhenium is rhenium-186.
Claim 6
Dependent Claim
27 words
A complex comprising rhenium-186 or rhenium-188 complexed 2-hydroxy isobutyric acid formed by reacting rhenium-186 or rhenium-188 with 2-hydroxy isobutyric acid in the presence of a reducing agent.
Claim 7
Dependent Claim
27 words
A complex comprising rhenium-186 or rhenium-188 complexed 2-hydroxy isobutyric acid formed by reacting rhenium-186 or rhenium-188 with 2-hydroxy isobutyric acid in the presence of a reducing agent.
Claim 8
Dependent Claim
22 words
The complex claimed in claim 5 wherein said reducing agent is selected from the group consisting of stannous chloride and sodium borohydride.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1992-06-12 | 1992-12-12 | 1993-06-13 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1996-06-12 | 1996-12-12 | 1997-06-13 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2000-06-12 | 2000-12-12 | 2001-06-13 | $7700.00 | Window Closed / Lapsed |