US4839169A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Synergistic combination of t-PA and prostacyclin
Assignee: Wellcome Foundation Ltd
•
Filing: 1987-08-04
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Granted: 1989-06-13
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Expires: 2007-08-04
Abstract
Abstract A combination of t-PA and a prostaglandin of use in removing or inhibiting the formation of a blood clot in a mammal.
Inventors
- 👤 Brendan J. R. Whittle
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-01 20:23
CPC Classifications
A; A61; A61K; A61K38/00; A61K38/16; A61K38/43; A61K38/46; A61K38/48; A61K38/49; A61P; A61P7/00; A61P7/02; Y; Y10; Y10S; Y10S930/00; Y10S930/01; Y10S930/26
Claims Analysis
Total Claims: 14
Claim 1
Independent Claim
50 words
A method of removing a blood clot in a mammal in need thereof comprising the parenteral administration to said mammal of t-PA and prostacyclin or a pharmaceutically acceptable salt thereof, wherein said t-PA and prostacyclin or said pharmaceutically acceptable salt thereof are administered in amounts to provide a synergistic effect.
Claim 2
Independent Claim
50 words
A method of removing a blood clot in a mammal in need thereof comprising the parenteral administration to said mammal of t-PA and prostacyclin or a pharmaceutically acceptable salt thereof, wherein said t-PA and prostacyclin or said pharmaceutically acceptable salt thereof are administered in amounts to provide a synergistic effect.
Claim 3
Dependent Claim
18 words
The method according to claim 1 in which the prostacyclin or salt thereof and t-PA are administered concurrently.
Claim 4
Dependent Claim
18 words
The method according to claim 1 in which the prostacyclin or salt thereof and t-PA are administered sequentially.
Claim 5
Independent Claim
113 words
A method of removing a blood clot in a mammal in need thereof comprising the parenteral administration to said mammal of t-PA and a compound of formula (I), said t-PA and a compound of formula (I), ##STR4## wherein R 1 is --(CH 2 ) 3 COR 4 or ##STR5## in which R 4 is hydroxy, C 1-4 alkoxy, amino, C 1-4 alkylamino or di-C 1-4 alkylamino, R 2 is n-pentyl, cyclopentyl, cyclohexyl or 1-methyl-3-pentynyl, R 3 is hydrogen or methyl, and X is oxygen, or a pharmaceutically acceptable salt thereof, wherein said compound of formula (I) or said pharmaceutically acceptable salt thereof and t-PA are administered in amounts to provide a synergistic effect.
Claim 6
Independent Claim
113 words
A method of removing a blood clot in a mammal in need thereof comprising the parenteral administration to said mammal of t-PA and a compound of formula (I), said t-PA and a compound of formula (I), ##STR4## wherein R 1 is --(CH 2 ) 3 COR 4 or ##STR5## in which R 4 is hydroxy, C 1-4 alkoxy, amino, C 1-4 alkylamino or di-C 1-4 alkylamino, R 2 is n-pentyl, cyclopentyl, cyclohexyl or 1-methyl-3-pentynyl, R 3 is hydrogen or methyl, and X is oxygen, or a pharmaceutically acceptable salt thereof, wherein said compound of formula (I) or said pharmaceutically acceptable salt thereof and t-PA are administered in amounts to provide a synergistic effect.
Claim 7
Dependent Claim
21 words
The method according to claim 4 in which the compound of formula I or salt thereof and t-PA are administered concurrently.
Claim 8
Dependent Claim
21 words
The method according to claim 4 in which the compound of formula (I) or salt thereof and t-PA are administered sequentially.
Claim 9
Independent Claim
106 words
A method of removing a blood clot in a mammal in need thereof comprising the parenteral administration to said mammal of t-PA and a compound of formula (I), ##STR6## wherein R 1 is --(CH 2 ) 3 COR 4 or ##STR7## in which R 4 is hydroxy, C 1-4 alkoxy, amino, C 1-4 alkylamino or di-C 1-4 alkylamino, R 2 is n-pentyl, cyclopentyl, cyclohexyl or 1-methyl-3-pentynyl, R 3 is hydrogen or methyl, and X is methylene, or a pharmaceutically acceptable salt thereof, wherein said t-PA and the compound of formula (I) or said pharmaceutically acceptable salt thereof are administered in amounts to provide a synergistic effect.
Claim 10
Independent Claim
106 words
A method of removing a blood clot in a mammal in need thereof comprising the parenteral administration to said mammal of t-PA and a compound of formula (I), ##STR6## wherein R 1 is --(CH 2 ) 3 COR 4 or ##STR7## in which R 4 is hydroxy, C 1-4 alkoxy, amino, C 1-4 alkylamino or di-C 1-4 alkylamino, R 2 is n-pentyl, cyclopentyl, cyclohexyl or 1-methyl-3-pentynyl, R 3 is hydrogen or methyl, and X is methylene, or a pharmaceutically acceptable salt thereof, wherein said t-PA and the compound of formula (I) or said pharmaceutically acceptable salt thereof are administered in amounts to provide a synergistic effect.
Claim 11
Dependent Claim
21 words
The method according to claim 7 in which the compound of formula I or salt thereof and t-PA are administered concurrently.
Claim 12
Dependent Claim
18 words
The method according to claim 8 in which the compound or salt thereof and t-PA are administered sequentially.
Claim 13
Dependent Claim
32 words
The method of claim 7 in which the compound of R is --(CH 2 ) 3 COR 4 in which R 4 is hydroxy, R 2 is 1-methyl-3-pentynyl, R 3 is hydrogen.
Claim 14
Dependent Claim
30 words
The method of claim 7 in which R 1 is (CH 2 ) 3 COR 4 in which R 4 hydroxy, R 2 in n-pentyl and R 3 is hydrogen.
References Cited (Backward Citations)
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Cited
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Cited
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Cited
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