US4539333A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Prostacyclin, methods of using and method of making
Assignee: SmithKline Beecham Corp
•
Filing: 1977-05-10
•
Granted: 1985-09-03
•
Expires: 1997-05-10
Abstract
Abstract Prostacyclin, its salts, biosynthesis and synthesis thereof, pharmaceutical formulations containing them, and their use in medicine.
Inventors
- 👤 Salvador Moncada
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-01 21:55
CPC Classifications
C; C07; C07D; C07D307/00; C07D307/77; C07D307/93; C07D307/935; C07D307/937
Claims Analysis
Total Claims: 17
Claim 1
Independent Claim
7 words
Prostacyclin substantially free from other biological material.
Claim 2
Dependent Claim
7 words
Prostacyclin substantially free from other biological material.
Claim 3
Independent Claim
23 words
The method of treating thrombosis in a mammal which comprises administering an effective antithrombotic portion of prostacyclin to said mammal in need thereof.
Claim 4
Independent Claim
23 words
The method of treating thrombosis in a mammal which comprises administering an effective antithrombotic portion of prostacyclin to said mammal in need thereof.
Claim 5
Independent Claim
25 words
The method of inhibiting the aggregation of blood platelets in a mammal which comprises administering an effective platelet antiaggregation amount of prostacyclin to said mammal.
Claim 6
Independent Claim
25 words
The method of inhibiting the aggregation of blood platelets in a mammal which comprises administering an effective platelet antiaggregation amount of prostacyclin to said mammal.
Claim 7
Independent Claim
24 words
A method of preventing thrombosis in a mammal in need thereof which comprises administering an effective thrombosis prevention amount of prostacyclin to said mammal.
Claim 8
Independent Claim
24 words
A method of preventing thrombosis in a mammal in need thereof which comprises administering an effective thrombosis prevention amount of prostacyclin to said mammal.
Claim 9
Independent Claim
28 words
A method for the prevention or treatment of gastric lessions in a mammal comprising the administration of a non-toxic prevention or treatment amount of prostacylin to said mammal.
Claim 10
Independent Claim
28 words
A method for the prevention or treatment of gastric lessions in a mammal comprising the administration of a non-toxic prevention or treatment amount of prostacylin to said mammal.
Claim 11
Independent Claim
24 words
A method for the treatment of a wound in a mammal which comprises administering to said mammal a non-toxic wound treatment amount of prostacylin.
Claim 12
Independent Claim
24 words
A method for the treatment of a wound in a mammal which comprises administering to said mammal a non-toxic wound treatment amount of prostacylin.
Claim 13
Independent Claim
30 words
A method for producing a vasodilatory action in the blood vessels of a mammal in need thereof comprising the administration of an effective vasodilatory amount of prostacyclin to said mammal.
Claim 14
Independent Claim
30 words
A method for producing a vasodilatory action in the blood vessels of a mammal in need thereof comprising the administration of an effective vasodilatory amount of prostacyclin to said mammal.
Claim 15
Independent Claim
19 words
The method of preparing (5-Z)-5,6-Didehydro-9-deoxy-6,9α-epoxyprostaglandin F 1 α which comprises incubating microsomes of mammalian tissue with a prostaglandin endoperoxide.
Claim 16
Independent Claim
19 words
The method of preparing (5-Z)-5,6-Didehydro-9-deoxy-6,9α-epoxyprostaglandin F 1 α which comprises incubating microsomes of mammalian tissue with a prostaglandin endoperoxide.
Claim 17
Dependent Claim
23 words
The method of claim 8 in which the microsomes are aortic microsomes and the prostaglandin endoperoxides are PGG 2 or PGH 2 .
References Cited (Backward Citations)
US4158667A
Cited
US4338325A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1988-09-02 | 1989-03-04 | 1989-09-03 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1992-09-02 | 1993-03-04 | 1993-09-03 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1996-09-02 | 1997-03-04 | 1997-09-03 | $7700.00 | Window Closed / Lapsed |