Patent US4837024A successfully refreshed from Google Patents.
US4837024A
Expired / Lapsed
US
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Compositions, articles and mehtod for improving wound healing
Assignee: University of California, San Diego
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Filing: 1988-05-13
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Granted: 1989-06-06
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Expires: 2008-05-13
Abstract
Abstract The healing of a surface wound is promoted by contacting the wound surfaces with a suspension of particles of collagen and a glycosaminoglycan that is chemotactic of fibroblasts and/or endothelial cells. Typical glycosaminoglycans that exhibit the desired chemotaxis are heparin, heparan sulfate, and alginate. Two or more glycosaminoglycans can be present in the suspensions. Collagen and glycosaminoglycan are present as a dry powdered suspension of particles. Preferably, collagen is present in the suspension in the order of 7-10 mg/ml; while the glycosaminoglycan is present in much lower concentrations, e.g., 250-350 mu g/ml. Application of the collagen/glycosaminoglycan suspension to open wounds greatly increases the rate of healing. The invention includes, an article, useful in the therapy for surface wounds, comprising the suspension of particles on a gauze, bandage tape or the like.
Inventors
- 👤 Dov Michaeli
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-03 19:22
CPC Classifications
A; A61; A61K; A61K38/00; A61K38/16; A61K38/17; A61K38/39
Claims Analysis
Total Claims: 19
Claim 1
Independent Claim
78 words
An article of manufacture for use in promoting the healing of a surface wound, which article comprises: a suspension of collagen fibrils in admixture with a minor amount of glycosaminoglycan wherein said glycosaminoglycan is chemotactic for fibroblasts or endothelial cells and the collagen is not covalently crosslinked to the glycosaminoglycan, wherein the suspension is located on the surface of a suitable carrier selected from the group consisting of a sterile bandage, a fabric, a gauze or a tape.
Claim 2
Dependent Claim
78 words
An article of manufacture for use in promoting the healing of a surface wound, which article comprises: a suspension of collagen fibrils in admixture with a minor amount of glycosaminoglycan wherein said glycosaminoglycan is chemotactic for fibroblasts or endothelial cells and the collagen is not covalently crosslinked to the glycosaminoglycan, wherein the suspension is located on the surface of a suitable carrier selected from the group consisting of a sterile bandage, a fabric, a gauze or a tape.
Claim 3
Dependent Claim
15 words
The article of claim 1 wherein two or more glycosaminoglycans are combined in the suspension.
Claim 4
Dependent Claim
10 words
The article of claim 1 wherein the glycosaminoglycan is heparin.
Claim 5
Dependent Claim
11 words
The article of claim 1 wherein the glycosaminoglycan is heparin sulfate.
Claim 6
Dependent Claim
11 words
The article of claim 1 wherein the glycosamnoglycan is an alginate.
Claim 7
Dependent Claim
13 words
The article of claim 2 wherein the combined glycosaminoglycans are heparin and alginate.
Claim 8
Dependent Claim
26 words
The article of claim 1 wherein in the suspension the ratio of the concentration of collagen to the concentration of glycosaminoglycan is about 25-35 to 1.
Claim 9
Dependent Claim
10 words
The article of claim 7 wherein the glycosaminoglycan is heparin.
Claim 10
Dependent Claim
11 words
The article of claim 7 wherein the glycosaminoglycan is heparin sulfate.
Claim 11
Dependent Claim
11 words
The article of claim 7 wherein the glycosaminoglycan is an alginate.
Claim 12
Dependent Claim
17 words
The article of claim 7 wherein heparin and alginate as glycosaminoglycans are admixed together in the suspension.
Claim 13
Dependent Claim
24 words
The article of claim 1 wherein the suspension consists essentially of a major amount of collagen in admixture with a minor amount of glycosaminoglycan.
Claim 14
Dependent Claim
24 words
The article of claim 1 wherein the suspension consists essentially of a major amount of collagen in admixture with a minor amount of alginate.
Claim 15
Dependent Claim
29 words
The article of claim 1 wherein the suspension consists essentially of a major amount of collagen in admixture with a minor amount of a combination of heparin and alginate.
Claim 16
Dependent Claim
31 words
A method for promoting the healing of surface wounds wherein the article of claim 1 is applied repeatedly to the wound surface during the healing to effectively promote the healing process.
Claim 17
Dependent Claim
52 words
A method for promoting the healing of surface wounds wherein the article of claim 1 is applied repeatedly to the wound surface during the healing to effectively promote the healing process, and in the suspension the ratio of the concentration of collagen to the concentration of glycosaminoglycan is about 25-35 to 1.
Claim 18
Dependent Claim
44 words
A method for promoting the healing of surface wounds wherein the article of claim 1 is applied repeatedly to the wound surface during the healing to effectively promote the healing process, and in the suspension two or more glycosaminoglycans are combined in the suspension.
Claim 19
Dependent Claim
39 words
A method for promoting the healing of surface wounds wherein the article of claim 1 is applied repeatedly to the wound surface during the healing to effectively promote the healing process, and in the suspension the glycosaminoglycan is heparin.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1992-06-05 | 1992-12-05 | 1993-06-06 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1996-06-05 | 1996-12-05 | 1997-06-06 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2000-06-05 | 2000-12-05 | 2001-06-06 | $7700.00 | Window Closed / Lapsed |