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Patent US4835185A successfully refreshed from Google Patents.
US4835185A
Expired / Lapsed
US
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Immunomodulator for improving commercial performance of domestic animals
Assignee: Iowa State University Research Foundation Inc
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Filing: 1987-03-02
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Granted: 1989-05-30
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Expires: 2007-03-02
Abstract
Abstract The commercial performance of domestic animals is improved by feeding keto-isocaproate (KIC) in a form nutritionally utilizable by the animals. The KIC enhances blastogenesis of the animal's T-lymphocytes and reduces plasma cortisol levels. The result is a favorable effect on the immune function of the animal, and can be used to counteract stress-associated immunosuppression. The method is applicable to beef cattle, dairy cattle, sheep, goats, swine, and poultry, as raised, respectively, for meat, milk, wood, or egg production. Practical benefits may also include increased rates of gain and reduced cholesterol in meats and eggs, and increased milk, wool, and egg yields.
Inventors
- 👤 Steven L. Nissen
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-26 22:44
CPC Classifications
A; A23; A23K; A23K50/00; A23K50/70; A23K50/75; A23K20/00; A23K20/10; A23K20/105; A23K50/10
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
54 words
The method of activating the blastogenesis function of the immune systems of domestic animals selected from the group consisting of cattle, sheep, goats and swine, comprising administering alphaketoisocaproate (KIC) to the animals, said KIC being in the form utilizable by the animals and being administered in an amount enhancing blastogenesis of their T lymphocytes.
Claim 2
Independent Claim
54 words
The method of activating the blastogenesis function of the immune systems of domestic animals selected from the group consisting of cattle, sheep, goats and swine, comprising administering alphaketoisocaproate (KIC) to the animals, said KIC being in the form utilizable by the animals and being administered in an amount enhancing blastogenesis of their T lymphocytes.
Claim 3
Independent Claim
49 words
The method of counteracting stress-associated plasma cortisol elevation in domestic animals selected from the group consisting of cattle, sheep, goats, and swine, comprising administering alpha-ketoisocaproate (KIC) to the animals, said KIC being in a form utilizable by the animals and being administered in an amount reducing their plasma cortisol.
Claim 4
Independent Claim
49 words
The method of counteracting stress-associated plasma cortisol elevation in domestic animals selected from the group consisting of cattle, sheep, goats, and swine, comprising administering alpha-ketoisocaproate (KIC) to the animals, said KIC being in a form utilizable by the animals and being administered in an amount reducing their plasma cortisol.
Claim 5
Dependent Claim
11 words
The method of claim 2 in which said animals are cattle.
Claim 6
Independent Claim
23 words
The method of claims 1 or 2 in which said KIC is selected from the group consisting of sodium KIC and calcium KIC.
Claim 7
Independent Claim
21 words
The method of claims 1 or 2 in which said KIC is orally administered in admixture with an animal feed material.
Claim 8
Independent Claim
14 words
The method of claims 1 or 2 in which said KIC is parenterally administered.
Claim 9
Independent Claim
30 words
The method of claims 1 or 2 in which said animals are selected from the group consisting of cattle and sheep, and said KIC is administered in a rumen-protected form.
Claim 10
Independent Claim
14 words
The method of claims 1 or 2 in which said KIC is sodium KIC.
Claim 11
Independent Claim
14 words
The method of claims 1 or 2 in which said KIC is calcium KIC.
Claim 12
Independent Claim
13 words
The method of claims 1 or 2 in which said animals are swine.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1992-05-29 | 1992-11-28 | 1993-05-30 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1996-05-29 | 1996-11-28 | 1997-05-30 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2000-05-29 | 2000-11-28 | 2001-05-30 | $7700.00 | Window Closed / Lapsed |