US4828827A
Expired / Lapsed
US
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Process for augmenting soft tissue with cross-linked polyvinyl pyrrolidone
Assignee: Ethicon Inc
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Filing: 1986-12-12
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Granted: 1989-05-09
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Expires: 2006-12-12
Abstract
Abstract An aqueous gel of cross-linked polyvinyl pyrrolidone is used to augment soft tissue in a mammal.
Inventors
- 👤 Alex M. Henderson
- 👤 Loretta M. McKey
- 👤 A. Kim Gordon
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 03:27
CPC Classifications
A; A61; A61L; A61L27/00; A61L27/50; A61L27/52; A61L27/14; A61L27/16; A61P; A61P43/00
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
65 words
In a process for augmenting soft tissue in a living mammal which comprises administering a sterile implant to the mammal at the site of augmentation, the improvement which comprises employing as said implant a sterile aqueous gel consisting essentially of cross-linked polyvinyl pyrrolidone, said cross-linked polyvinyl pyrrolidone being present in said gel in a concentration of from about 5 to about 40 percent, by weight.
Claim 2
Dependent Claim
65 words
In a process for augmenting soft tissue in a living mammal which comprises administering a sterile implant to the mammal at the site of augmentation, the improvement which comprises employing as said implant a sterile aqueous gel consisting essentially of cross-linked polyvinyl pyrrolidone, said cross-linked polyvinyl pyrrolidone being present in said gel in a concentration of from about 5 to about 40 percent, by weight.
Claim 3
Dependent Claim
13 words
The process of claim 1 wherein said sterile gel is administered by injection.
Claim 4
Dependent Claim
21 words
The process of claim 1 wherein the gel is produced by subjecting an aqueous solution of polyvinyl pyrrolidone to ionizing radiation.
Claim 5
Dependent Claim
17 words
The process of claim 3 wherein the ionizing radiation is gamma rays from a Co 60 source.
Claim 6
Dependent Claim
34 words
The process of claim 3 wherein the concentration of polyvinyl pyrrolidone in the aqueous solution is within the range of from 5 to 40 percent by weight, based on total weight of the solution.
Claim 7
Dependent Claim
20 words
The process of claim 5 wherein said concentration is within the range of from 12 to 20 percent, by weight.
Claim 8
Dependent Claim
17 words
The process of claim 4 wherein the total dose of radiation is from 2 to 15 Mrads.
Claim 9
Dependent Claim
17 words
The process of claim 7 wherein the total dose of radiation is from 2.4 to 3.4 Mrads.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1992-05-08 | 1992-11-07 | 1993-05-09 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1996-05-08 | 1996-11-07 | 1997-05-09 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2000-05-08 | 2000-11-07 | 2001-05-09 | $7700.00 | Window Closed / Lapsed |