Patent US4828563A successfully refreshed from Google Patents.
US4828563A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Implant
Assignee: DR MULLER-LIERHEIM AG BEHRINGSTRASSE 6 8033 PLANEGG WEST GERMANY
•
Filing: 1987-08-13
•
Granted: 1989-05-09
•
Expires: 2007-08-13
Abstract
Abstract An implant having a surface coating of growth factors for animal or human cells, wherein the growth factors are covalently bonded to bonding-active groups of a polymer on the base body of the implant.
Inventors
- 👤 Wolfgang G. K. Muller-Lierheim
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 14:13
CPC Classifications
A; A61; A61L; A61L27/00; A61L27/36; A61L27/38; A61L27/14; A61L27/22; A61L27/227; A61L27/50; A61L27/54; A61L2300/00; A61L2300/20; A61L2300/252; A61L2300/256; A61L2300/40; A61L2300/412; A61L2300/414; A61L2300/60; A61L2300/606
Claims Analysis
Total Claims: 17
Claim 1
Independent Claim
74 words
An implant comprising: a rigid, implantable base body; a polymer layer anchored to the surface of said base body, said polymer layer having bonding-active groups at least on a polymer surface thereof remote from said base body polyclonal antibodies bonded to said polymer surface by said bonding-active groups; and growth factors for animal cells including bone substance-inducing proteins bound to said polyclonal antibodies, wherein said polyclonal antibodies are receptors for said bone substance-inducing proteins.
Claim 2
Dependent Claim
74 words
An implant comprising: a rigid, implantable base body; a polymer layer anchored to the surface of said base body, said polymer layer having bonding-active groups at least on a polymer surface thereof remote from said base body polyclonal antibodies bonded to said polymer surface by said bonding-active groups; and growth factors for animal cells including bone substance-inducing proteins bound to said polyclonal antibodies, wherein said polyclonal antibodies are receptors for said bone substance-inducing proteins.
Claim 3
Dependent Claim
17 words
An implant as set forth in claim 1 wherein said growth factors are animal cell metabolism products.
Claim 4
Dependent Claim
15 words
An implant as set forth in claim 1 wherein said growth factors include blood serum.
Claim 5
Dependent Claim
19 words
An implant as set forth in claim 1 wherein said growth factors include at least one blood serum constituent.
Claim 6
Dependent Claim
14 words
An implant as set forth in claim 3 wherein said growth factors include fibronectin.
Claim 7
Dependent Claim
24 words
An implant as set forth in claim 1 wherein said growth factors include a combination of cell metabolism product and biochemically modified natural product.
Claim 8
Dependent Claim
18 words
An implant as set forth in claim 1 wherein said growth factors include protein leading to cell differentiation.
Claim 9
Dependent Claim
20 words
An implant as set forth in claim 7 wherein said growth factors are in the form of bone powder extract.
Claim 10
Dependent Claim
23 words
An implant as set forth in claim 8 wherein said bone powder extract is bonded with an extracellular matrix to said polymer surface.
Claim 11
Dependent Claim
15 words
An implant as set forth in claim 1 wherein said polymer surface has oxirane groups.
Claim 12
Dependent Claim
31 words
An implant as set forth in claim 1 wherein said polymer is a copolymer comprising at least two monomers selected from the group consisting of methacrylate, N-methylene-bis-methacrylamide, allylglycidyl ether and glycidylmethacrylate.
Claim 13
Dependent Claim
14 words
An implant as set forth in claim 1 wherein said base body comprises metal.
Claim 14
Dependent Claim
16 words
An implant as set forth in claim 1 wherein said base body has anchoring means thereon.
Claim 15
Dependent Claim
24 words
An implant as set forth in claim 13 wherein said anchoring means comprise projections forming undercut configurations at the surface of said base body.
Claim 16
Dependent Claim
82 words
A bone implant comprising: a rigid, implantable base body; a polymer layer anchored to the surface of said base body, said polymer layer having bonding-active groups on a polymer surface remote from said base body; and polyclonal antibodies bonded to said polymer surface by said bonding-active groups, said polyclonal antibodies being receptor for bone substance-inducing proteins; wherein, upon implantation of said bone implant in an animal or human body, said polyclonal antibodies absorb bone substance-inducing proteins from the environment in the body.
Claim 17
Dependent Claim
82 words
A bone implant comprising: a rigid, implantable base body; a polymer layer anchored to the surface of said base body, said polymer layer having bonding-active groups on a polymer surface remote from said base body; and polyclonal antibodies bonded to said polymer surface by said bonding-active groups, said polyclonal antibodies being receptor for bone substance-inducing proteins; wherein, upon implantation of said bone implant in an animal or human body, said polyclonal antibodies absorb bone substance-inducing proteins from the environment in the body.
References Cited (Backward Citations)
US3983000A
Cited
US4071409A
Cited
US4164794A
Cited
US4565784A
Cited
US4451568A
Cited
US4458678A
Cited
US4505266A
Cited
US4542069A
Cited
US4568706A
Cited
US4608052A
Cited
DE3519073A1
Cited
US4598122A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1992-05-08 | 1992-11-07 | 1993-05-09 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1996-05-08 | 1996-11-07 | 1997-05-09 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2000-05-08 | 2000-11-07 | 2001-05-09 | $7700.00 | Window Closed / Lapsed |