US4816466A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Piperidine derivatives
Assignee: Takeda Pharmaceutical Co Ltd
•
Filing: 1988-04-12
•
Granted: 1989-03-28
•
Expires: 2008-04-12
Abstract
Abstract Novel Compounds of the formula: ##STR1## [wherein A is an α-amino acid residue; B is a group represented by the formula: ##STR2## (wherein R 4 is hydrogen, lower alkyl, aralkyl or amino-lower alkyl), whereby the linkage between the symbols A and B designates a peptide bond and the group R 4 is B may be linked with A; R 1 is hydrogen, lower alkyl or aralkyl; R 2 is hydrogen, lower alkyl, aralkyl or acyl; X is alkylene] and salts thereof posses, for example, inhibitory activity on angiotension converting enzyme, and are useful as an agent for diagnosis, prevention or treatment of hypertension as well as circulatory diseases such as cardiopathy and cerebral apoplexy.
Inventors
- 👤 Hirosada Sugihara
- 👤 Kohei Nishikawa
- 👤 Katsumi Ito
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-06 12:25
CPC Classifications
C; C07; C07K; C07K5/00; C07K5/02; C07K5/022; C07K5/0222; A; A61; A61K; A61K38/00
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
49 words
A compound of the formula ##STR173## wherein R 4' is lower alkyl; R 1 is hydrogen, lower alkyl or phenyl-lower alkyl; R 2 is hydrogen, lower alkyl, phenyl-lower alkyl, lower alkanoyl, benzoyl, phenyl-lower alkoxycarbonyl or lower alkoxycarbonyl; and X is C 1-7 alkylene; or a pharmaceutically acceptable salt thereof.
Claim 2
Dependent Claim
49 words
A compound of the formula ##STR173## wherein R 4' is lower alkyl; R 1 is hydrogen, lower alkyl or phenyl-lower alkyl; R 2 is hydrogen, lower alkyl, phenyl-lower alkyl, lower alkanoyl, benzoyl, phenyl-lower alkoxycarbonyl or lower alkoxycarbonyl; and X is C 1-7 alkylene; or a pharmaceutically acceptable salt thereof.
Claim 3
Dependent Claim
14 words
A compound according to claim 1, wherein R 1 is hydrogen or lower alkyl.
Claim 4
Dependent Claim
11 words
A compound according to claim 1, wherein R 1 is hydrogen.
Claim 5
Dependent Claim
11 words
A compound according to claim 1, wherein R 2 is hydrogen.
Claim 6
Dependent Claim
13 words
A compound according to claim 1, wherein X is trimethylene, tetramethylene or pentamethylene.
Claim 7
Dependent Claim
10 words
A compound according to claim 1, wherein X is tetramethylene.
Claim 8
Dependent Claim
9 words
A compound according to claim 1, which is N-[N-[(S)-1-carboxy-5-(4-piperidyl)pentyl]-L-alanyl]-N-(indan-2-yl)glycine
Claim 9
Dependent Claim
43 words
A pharmaceutical composition suitable for prevention or treatment of hypertension which comprises, as an active ingredient, an effective antihypertensive amount of a compound as claimed in claim 1 or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, excipient or diluent therefor.
Claim 10
Dependent Claim
35 words
A method for prevention or treatment of hypertension in a mammal, which comprises administering to said mammal an effective antihypertensive amount of a compound as claimed in claim 1 or a pharmaceutically acceptable salt thereof.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1992-03-27 | 1992-09-26 | 1993-03-28 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1996-03-27 | 1996-09-26 | 1997-03-28 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2000-03-27 | 2000-09-26 | 2001-03-28 | $7700.00 | Window Closed / Lapsed |