Patent US4816438A successfully refreshed from Google Patents.
US4816438A
Expired / Lapsed
US
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Insulin-selective somatostatin analogs
Assignee: Salk Institute for Biological Studies
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Filing: 1987-04-01
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Granted: 1989-03-28
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Expires: 2007-04-01
Abstract
Abstract Anglerfish somatostatin-28 has the formula: ##STR1## Anglerfish somatostation-28 is insulin-selective when administered in vivo and is useful for the treatment of insulinoma. The 14-residue C-terminal peptide may also be used.
Inventors
- 👤 Joachim Spiess
- 👤 Bryan D. Noe
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-01 14:26
CPC Classifications
C; C07; C07K; C07K14/00; C07K14/435; C07K14/575; C07K14/655; A; A61; A61K; A61K38/00; Y; Y10; Y10S; Y10S930/00; Y10S930/01; Y10S930/16
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
38 words
A pharmaceutical composition for the treatment of insulinoma comprising an effective amount of a compound selected from the group consisting of ##STR12## or a nontoxic addition salt of either, plus a pharmaceutically acceptable liquid or solid carrier therefor.
Claim 2
Dependent Claim
38 words
A pharmaceutical composition for the treatment of insulinoma comprising an effective amount of a compound selected from the group consisting of ##STR12## or a nontoxic addition salt of either, plus a pharmaceutically acceptable liquid or solid carrier therefor.
Claim 3
Dependent Claim
15 words
A pharmaceutical composition in accordance with claim 1 wherein said compound has the formula: ##STR13##
Claim 4
Dependent Claim
35 words
A compound selected from the group consisting of ##STR14## the linear version thereof where the disulfide bridge is replaced by hydrogen, ##STR15## and the linear version thereof where the disulfide bridge is replaced by hydrogen.
Claim 5
Dependent Claim
35 words
A compound selected from the group consisting of ##STR14## the linear version thereof where the disulfide bridge is replaced by hydrogen, ##STR15## and the linear version thereof where the disulfide bridge is replaced by hydrogen.
Claim 6
Dependent Claim
11 words
A compound in accordance with claim 3 having the formula: ##STR16##
Claim 7
Independent Claim
27 words
A method of treating insulinoma comprising administering an effective amount of a compound selected from the group consisting of ##STR17## and the nontoxic addition salts of either.
Claim 8
Independent Claim
27 words
A method of treating insulinoma comprising administering an effective amount of a compound selected from the group consisting of ##STR17## and the nontoxic addition salts of either.
Claim 9
Dependent Claim
16 words
A method of treatment in accordance with claim 5 wherein said compound has the formula ##STR18##
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1992-03-27 | 1992-09-26 | 1993-03-28 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1996-03-27 | 1996-09-26 | 1997-03-28 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2000-03-27 | 2000-09-26 | 2001-03-28 | $7700.00 | Window Closed / Lapsed |