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US4815447A Expired / Lapsed US ⏱️ 0.0 years remaining

Mossbauer cancer therapy

Assignee: Individual
•
Filing: 1985-03-19
•
Granted: 1989-03-28
•
Expires: 2005-03-19
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Abstract

Abstract Frequency selective radiation therapy providing selective tissue damage or necrosis by irradiating a component element of the target tissue at the corresponding Mossbauer absorption frequency. The component radiation absorption at the Mossbauer absorption frequency is thus enhanced many times over the absorption of the surrounding tissue having a different Mossbauer absorption frequency. The energy thusly absorbed by the target tissue component is converted to and remitted as Auger electrons, which provide intranuclear radiation resulting in lethal double strand breaks in the DNA molecules of the target tissue. The therapy is administered in frequency and tissue selective modes of treatment, and may be combined with conventional chemotherapeutic agents to provide a further enhanced treatment modality. Moreover, the source frequency can be adjusted to enhance the killing effect. The therapy method and apparatus according to the present invention is useful in combination with naturally occurring or administered pharmaceutical stable isotope absorbers, having significantly reduced side effects by comparison to convention chemotherapy or radiation therapy.

Inventors

  • 👤 Randell L. Mills

Bibliographic Details

Application Number —
Jurisdiction US
Data Source google_patents
Last Synchronized 2026-10-27 18:53
CPC Classifications
A; A61; A61K; A61K41/00; A61K41/0085; A61K51/00; A61K51/12; A61N; A61N5/00; A61N5/10; A61K2121/00; A61N2005/1092; A61N2005/1098

Claims Analysis

Total Claims: 12
Claim 1
Independent Claim 97 words
A system for therapeutic administration of radiation for selective necrosis of target tissue, comprising a source of radiation selectively providing at least one frequency of radiation emission; means for tuning the frequency of said source radiation; and means for selective absorption of said emission administered to said target tissue, wherein said source is directed to provide said radiation to said target tissue and is adjusted to provide sufficient radiation at the frequency corresponding to the Mossbauer frequency of the means for selective absorption to provide target tissue necrosis, and said radiation comprises radiation applicable to Mossbauer absorption.
Claim 2
Independent Claim 97 words
A system for therapeutic administration of radiation for selective necrosis of target tissue, comprising a source of radiation selectively providing at least one frequency of radiation emission; means for tuning the frequency of said source radiation; and means for selective absorption of said emission administered to said target tissue, wherein said source is directed to provide said radiation to said target tissue and is adjusted to provide sufficient radiation at the frequency corresponding to the Mossbauer frequency of the means for selective absorption to provide target tissue necrosis, and said radiation comprises radiation applicable to Mossbauer absorption.
Claim 3
Dependent Claim 14 words
The system of claim 1, wherein said means for tuning comprises Doppler shift means.
Claim 4
Dependent Claim 13 words
The system of claim 1, wherein said filter means comprises crystal diffraction means.
Claim 5
Dependent Claim 32 words
The system of claim 1, wherein the excited component of said target tissue emits radiation causing necrosis of said target tissue, the apparatus further comprising means for detecting said target tissue radiation.
Claim 6
Dependent Claim 30 words
The system of claim 1, further comprising means for sensing target tissue fluorescence in response to said radiation, said fluorescence being emitted along a path off-axis from the incident radiation.
Claim 7
Dependent Claim 19 words
The system of claim 4, further comprising means for imaging said target tissue according to said target tissue radiation.
Claim 8
Dependent Claim 36 words
The system of claim 1, wherein said means for selective absorption comprises at least one of a molecule, a protein, and a peptide, wherein said means for selective absorption further includes naturally occurring and synthesized elements.
Claim 9
Dependent Claim 21 words
The system of claim 7, wherein said means for selective absorption comprises at least one of an isotope and a hormone.
Claim 10
Dependent Claim 14 words
The system of claim 8, wherein said means for selective absorption comprises a pharmaceutical.
Claim 11
Dependent Claim 20 words
The system of claim 1, further including filter means for selective transmittance of said radiation emission for providing filtered radiation.
Claim 12
Dependent Claim 15 words
The system of claim 1, wherein said radiation applicable to Mossbauer absorption comprises gamma rays.

References Cited (Backward Citations)

US3057998A Cited
US3257558A Cited
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US3794840A Cited
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WO1985001871A1 Cited
EP0198257A2 Cited

USPTO Annuity & Maintenance Windows

Annuity Stage Window Opens Payment Deadline Surcharge Period Until Estimated Fee Status
3.5 Years (Year 4) 1992-03-27 1992-09-26 1993-03-28 $2000.00 Window Closed / Lapsed
7.5 Years (Year 8) 1996-03-27 1996-09-26 1997-03-28 $3760.00 Window Closed / Lapsed
11.5 Years (Year 12) 2000-03-27 2000-09-26 2001-03-28 $7700.00 Window Closed / Lapsed

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