US4814176A
Expired / Lapsed
US
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Sustained release preparation
Assignee: Teijin Ltd
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Filing: 1986-01-10
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Granted: 1989-03-21
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Expires: 2006-01-10
Abstract
Abstract A sustained release preparation comprising: (a) chitin, chitosan, or a mixture thereof (b) anionic polymer compounds such as those having a carboxyl group, a sulfonic acid group, or a group capable of providing the same, and (c) pharmaceutically active agents. This sustained release preparation can provide the desired sustained-release or dissolution of the pharmaceutically active agents in human organs irrespective of the acidity (i.e., pH conditions) therein.
Inventors
- 👤 Yuji Makino
- 👤 Hideo Matugi
- 👤 Yoshiki Suzuki
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-01 04:07
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/20; A61K9/2004; A61K9/2022; A61K9/205; A61K9/2027; A61K9/2054; A61K9/48; A61K9/4841; A61K9/4866
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
60 words
A sustained release preparation consisting essentially of: (a) chitin, chitosan, or a mixture thereof; (b) at least one anionic polymer compound, and (c) a pharmaceutically effective amount of at least one pharmaceutically active agent, wherein (b) is present in said preparation in a ratio of from 10 to b 1,000 parts by weight per 100 parts by weight of (a).
Claim 2
Dependent Claim
60 words
A sustained release preparation consisting essentially of: (a) chitin, chitosan, or a mixture thereof; (b) at least one anionic polymer compound, and (c) a pharmaceutically effective amount of at least one pharmaceutically active agent, wherein (b) is present in said preparation in a ratio of from 10 to b 1,000 parts by weight per 100 parts by weight of (a).
Claim 3
Dependent Claim
32 words
A sustained release preparation as claimed in claim 1, wherein the anionic polymer compounds are those having a carboxyl group, a sulfonic acid group, or a group capable of providing the same.
Claim 4
Dependent Claim
28 words
A sustained release preparation as claimed in claim 1, wherein the anionic polymer compounds are those having a carboxyl group or a group capable of providing the same.
Claim 5
Dependent Claim
70 words
A sustained release preparation as claimed in claim 1, wherein the anionic polymer compound is at least one compound selected from the group consisting of carboxyvinyl polymer and the salts thereof, polyacrylic acid and the salts thereof, methoxyethylene-maleic anhydride copolymer and the hydrolyzates thereof, methacrylic acid-methyl methacrylate copolymer, partial methyl esters of vinyl acetate-maleic anhydride copolymer, vinyl acetate-crotonic acid copolymer, carboxymethyl cellulose, alginic acid, pectin, hyaluronic acid, and poly-L-glutamic acid.
Claim 6
Dependent Claim
58 words
A sustained release preparation as claimed in claim 1, wherein the pharmaceutically active agent is at least one member selected from the group consisting of antipyretic, analgesic, or antiphlogistics, antiarrhythmics, hypotensors, vasodilators, antiarteriosclerotics, agents for circulatory systems, antitussive expectorants, ulcer preventives, enzyme preparations, antimalignants, chemotherapeutic agents, antiphlogistic steroid agents, antihistamine agents, local anesthetic agents, and mouth disinfection agents.
Claim 7
Dependent Claim
23 words
A sustained release preparation as claimed in claim 1 in the form of tablets, granules, grains, powders, dental cones, films, or hard capsules.
Claim 8
Dependent Claim
22 words
A method for administering a sustained release preparation according to claim 1 whereby the pharmaceutically active agent contained therein is gradually released.
Claim 9
Dependent Claim
16 words
A method as claimed in claim 7, wherein the preparation is perorally, intraorally or intranasally administered.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1992-03-20 | 1992-09-19 | 1993-03-21 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1996-03-20 | 1996-09-19 | 1997-03-21 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2000-03-20 | 2000-09-19 | 2001-03-21 | $7700.00 | Window Closed / Lapsed |