US4814175A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Nifedipine combination preparation
Assignee: Bayer Pharma AG
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Filing: 1987-03-18
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Granted: 1989-03-21
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Expires: 2007-03-18
Abstract
Abstract The invention relates to nifedipine combination preparations, containing nifedipine with delayed release of active agent and a β-blocker in each case in granulated form, and their pharmaceutical usage as a therapeutic agent in cardiovascular diseases.
Inventors
- 👤 Johannes-Wilhelm Tack
- 👤 Manfred Albring
- 👤 Fred Windt-Hanke
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-08 02:01
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/48; A61K9/50; A61K9/5084; A61K31/00; A61K31/33; A61K31/395; A61K31/435; A61K31/44
Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
26 words
A gelatin capsule containing 1 part by weight of granulated nifidepine having a particle diameter of 10-50 μm and 0.01-0.5 parts by weight of granulated mepindolol.
Claim 2
Dependent Claim
26 words
A gelatin capsule containing 1 part by weight of granulated nifidepine having a particle diameter of 10-50 μm and 0.01-0.5 parts by weight of granulated mepindolol.
Claim 3
Dependent Claim
20 words
The capsule of claim 1 wherein both the granulated nifidepine and granulated mepindolol are coated before dispensing into the capsule.
Claim 4
Dependent Claim
14 words
The capsule of claim 1 further comprising auxiliary agents and excipients added before granulation.
Claim 5
Dependent Claim
21 words
Combination preparation according to claim 1, characterized in that the nifedipine component of the combination exhibits retarded release of active compound.
Claim 6
Dependent Claim
16 words
A process for treating cardiovascular disease which comprises the administration of the capsule of claim 1.
Claim 7
Dependent Claim
22 words
Combination preparation according to claim 1, characterized in that the granulated nifedipine and the granulated mepindolol are provided in one two-piece capsule.
References Cited (Backward Citations)
US4281654A
Cited
GB2084017A
Cited
US4510150A
Cited
EP0142561A1
Cited
US4668770A
Cited
US4690935A
Cited
EP0165450A2
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1992-03-20 | 1992-09-19 | 1993-03-21 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1996-03-20 | 1996-09-19 | 1997-03-21 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2000-03-20 | 2000-09-19 | 2001-03-21 | $7700.00 | Window Closed / Lapsed |