EP0142561A1
Expired / Lapsed
EP
⏱️ 0.0 years remaining
Long-acting nifedipine preparation
Assignee: Kanebo Ltd
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Filing: 1983-03-05
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Granted: —
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Expires: 2003-03-05
Abstract
Abstract @ A novel long-acting, easily absorbable nifedipine preparation which is prepared by compounding the following compositions (A) and (B) in a weight ratio, in terms of nifedipine, of 15:85 to 50 :50: composition (A): a fast-release preparation composition containing as an effective ingredient fine nifedipine particles having a mean particle size of 5 µ or less; and composition (B): a slow-release preparation composition containing as an effective ingredient fine nifedipine particles having a mean particle size of 5 µ or less and having provided thereon a coating film composed of a difficultly water-soluble, non-toxic substance and an enteric polymer.
Inventors
- 👤 Isao Sugimoto
- 👤 Kazunori Togo
- 👤 Kozo Sasaki
- 👤 Atsushi Yamagata
- 👤 Akira Kuchiki
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-11-09 08:19
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/33; A61K31/395; A61K31/435; A61K31/44; A61K9/00; A61K9/48; A61K9/50; A61K9/5084
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
93 words
A sustained-release nifedipine preparation which comprises the following Composition (A) and Composition (B) in a ratio of 15 ; 85 to 50 : 50 by weight of nifedipine, Composition (A): a rapid-release preparation containing as an active ingredient nifedipine fine powder having an average particle size of not more than 5 . Composition (B): a delayed-release preparation containing as the active ingredient nifedipine fine powder having an average particle size of not more than 5 and having a surface coating layer comprising a non-toxic, hardly water-soluble substance and an enteric high molecular compound.
Claim 2
Dependent Claim
93 words
A sustained-release nifedipine preparation which comprises the following Composition (A) and Composition (B) in a ratio of 15 ; 85 to 50 : 50 by weight of nifedipine, Composition (A): a rapid-release preparation containing as an active ingredient nifedipine fine powder having an average particle size of not more than 5 . Composition (B): a delayed-release preparation containing as the active ingredient nifedipine fine powder having an average particle size of not more than 5 and having a surface coating layer comprising a non-toxic, hardly water-soluble substance and an enteric high molecular compound.
Claim 3
Dependent Claim
23 words
The sustained-release nifedipine preparation according to claim 1, wherein the nifedipine fine powder has an average particle size of 1 to 4 .
Claim 4
Dependent Claim
22 words
The sustained-release nifedipine preparation according to claim 2, wherein the nifedipine fine powder has an average particle size of about 2 .
Claim 5
Dependent Claim
33 words
The sustained-release nifedipine preparation according to claim 1, wherein the non-toxic, hardly water-soluble substance is a member selected from oils and fats and ethyl cellulose or a mixture of two or more thereof.
Claim 6
Dependent Claim
21 words
The sustained-release nifedipine preparation according to claim 4, wherein the oils and fats are hydrogenated oils or fatty acid glycerin esters.
Claim 7
Dependent Claim
34 words
The sustained-release nifedipine preparation according to claim 1, wherein the hardly water-soluble substance and the enteric high molecular compound are mixed in a ratio of 1 : 5 to 5 : 1 (weight ratio).
Claim 8
Dependent Claim
34 words
The sustained-release nifedipine preparation according to claim 6, wherein the hardly water-soluble substance and the enteric high molecular compound are mixed in a ratio of 1 : 2 to 2 : 1 (weight ratio).
Claim 9
Dependent Claim
31 words
The sustained-release nifedipine preparation according to claim 1, wherein Composition (A) and Composition (B) are mixed in a ratio of 20 : 80 to 40 : 60 by weight of nifedipine.
Claim 10
Dependent Claim
19 words
The sustained-release nifedipine preparation according to claim 1, wherein the preparation is in the form of a non-compressed type.
Claim 11
Dependent Claim
57 words
The sustained-release nifedipine preparation according to claim 9, wherein the preparation form is a granule or fine granule preparation which is prepared by mixing a granular or fine granular Composition (A) and a granular or fine granular Composition (B), or a capsule preparation which is prepared by packing said granule or fine granule preparation into a capsule.
References Cited (Backward Citations)
No citation records indexed.
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