Patent US4814173A successfully refreshed from Google Patents.
US4814173A
Expired / Lapsed
US
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Silicone elastomer transdermal matrix system
Assignee: Warner Lambert Co LLC
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Filing: 1987-09-08
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Granted: 1989-03-21
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Expires: 2007-09-08
Abstract
Abstract A composition for the transmembranal, including transdermal administration of a pharmaceutical preparation comprising medical grade dimethylsiloxane, a catalyst capable of forming an elastomer, a permeation enhancer and a biologically active material, as well as a device for administering the aforementioned compositions and also a method for administering transdermally to a mammal an effective amount of the aforementioned compositions is herein described.
Inventors
- 👤 Suk-Zu Song
- 👤 Zahra A. Rashidbaigi
- 👤 Surendra C. Mehta
- 👤 Russell U. Nesbitt
- 👤 Mahdi B. Fawzi
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-06 20:20
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/70; A61K9/7023; A61K9/703; A61K9/7038; A61K9/7046; A61K9/7069; A61K47/00; A61K47/30; A61K47/34
Claims Analysis
Total Claims: 30
Claim 1
Independent Claim
38 words
A composition for the transmembranal, including transdermal, administration of a pharmaceutical preparation comprising medical grade dimethylsiloxane, a catalyst capable of forming an elastomer wherein said catalyst is dibutyl tin dilaurate, a permeation enhancer, and a biologically active material.
Claim 2
Dependent Claim
38 words
A composition for the transmembranal, including transdermal, administration of a pharmaceutical preparation comprising medical grade dimethylsiloxane, a catalyst capable of forming an elastomer wherein said catalyst is dibutyl tin dilaurate, a permeation enhancer, and a biologically active material.
Claim 3
Dependent Claim
52 words
A composition of claim 1 where the permeation enhancer consists of a saturated or unsaturated fatty acid containing from eight to twenty-four carbon atoms and a solvent or solvents selected from the group consisting of propylene glycol, glycerol, ethanol, triacetin, triethyl citrate, dimethylisosorbide, ethylene glycol, propoxylated cetyl alcohol, 1-N-dodecylazacycloheptan-2-one and alkyl sulfoxides.
Claim 4
Dependent Claim
16 words
A composition of claim 1 where the permeation enhancer is linoleic acid, triacetin, and propylene glycol.
Claim 5
Dependent Claim
13 words
A composition of claim 1 where the biologically active material is a sedative.
Claim 6
Dependent Claim
13 words
A composition of claim 1 where the biologically active material is a tranquilizer.
Claim 7
Dependent Claim
13 words
A composition of claim 1 where the biologically active material is an antihistamine.
Claim 8
Dependent Claim
14 words
A composition of claim 1 where the biologically active material is a cognition activator.
Claim 9
Dependent Claim
13 words
A composition of claim 1 where the biologically active material is an antihypertensive.
Claim 10
Dependent Claim
13 words
A composition of claim 1 where the biologically active material is an analgesic.
Claim 11
Dependent Claim
13 words
A composition of claim 1 where the biologically active material is an antiarrhythmic.
Claim 12
Dependent Claim
13 words
A composition of claim 1 where the biologically active material is a cardiotonic.
Claim 13
Dependent Claim
13 words
A composition of claim 1 where the biologically active material is a bronchodilator.
Claim 14
Dependent Claim
13 words
A composition of claim 1 where the biologically active material is a peptide.
Claim 15
Dependent Claim
14 words
A composition of claim 1 where the biologically active material is a basic drug.
Claim 16
Dependent Claim
12 words
A composition of claim 1 where the biologically active material is diphenhydramine.
Claim 17
Dependent Claim
12 words
A composition of claim 1 where the biologically active material is chlorpheniramine.
Claim 18
Dependent Claim
12 words
A composition of claim 1 where the biologically active material is atenolol.
Claim 19
Dependent Claim
12 words
A composition of claim 1 where the biologically active material is propanolol.
Claim 20
Dependent Claim
12 words
A composition of claim 1 where the biologically active material is morphine.
Claim 21
Dependent Claim
12 words
A composition of claim 1 where the biologically active material is meperidine.
Claim 22
Dependent Claim
12 words
A composition of claim 1 where the biologically active material is pentazocine.
Claim 23
Dependent Claim
12 words
A composition of claim 1 where the biologically active material is ergotamine.
Claim 24
Dependent Claim
9 words
A transdermal device comprising the composition of claim 1.
Claim 25
Dependent Claim
24 words
A transdermal device according to claim 23 which is selected from the group consisting of a patch, film, spray, swab, suppository, cream or gel.
Claim 26
Dependent Claim
9 words
A transdermal device comprising the composition of claim 15.
Claim 27
Dependent Claim
9 words
A transdermal device comprising the composition of claim 16.
Claim 28
Dependent Claim
30 words
A method for administering a biologically active material transdermally to a mammal which comprises applying to the skin of said mammal an effective amount of the composition of claim 1.
Claim 29
Dependent Claim
12 words
A method of claim 27 where the biologically active material is diphenhydramine.
Claim 30
Dependent Claim
12 words
A method of claim 27 where the biologically active material is chlorpheniramine.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1992-03-20 | 1992-09-19 | 1993-03-21 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1996-03-20 | 1996-09-19 | 1997-03-21 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2000-03-20 | 2000-09-19 | 2001-03-21 | $7700.00 | Window Closed / Lapsed |