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US4810699A
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Substituted 1,3,4,9-tetrahydropyrano[3,4,-b]indole-1-acetic acids, pharmaceutical compositions containing them, and methods for treating inflammatory conditions and for analgesic purposes using them
Assignee: Wyeth LLC
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Filing: 1987-09-21
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Granted: 1989-03-07
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Expires: 2007-09-21
Abstract
Abstract Indole derivatives characterized by having a 1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic acid nucleus bearing a substituent in position 1,5, 6, 7 and 8. The derivatives are useful anti-inflammatory and analgesic agents and methods for their preparation and use are also disclosed.
Inventors
- 👤 Joseph P. Sabatucci
- 👤 Christopher A. Demerson
- 👤 Amadeo A. Failli
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-02 07:15
CPC Classifications
C; C07; C07D; C07D491/00; C07D491/02; C07D491/04
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
48 words
The compounds having the structure ##STR5## wherein R 1 is hydrogen, lower alkyl containing 1 to 4 carbon atoms or halogen, R 2 is --O--CH 2 --CH═CH 2 , --O--CH 2 --CF 3 , --O--CH(CH 3 )--CF 3 , --O--CH 2 --C.tbd.CH and the pharmaceutically acceptable salts thereof.
Claim 2
Dependent Claim
48 words
The compounds having the structure ##STR5## wherein R 1 is hydrogen, lower alkyl containing 1 to 4 carbon atoms or halogen, R 2 is --O--CH 2 --CH═CH 2 , --O--CH 2 --CF 3 , --O--CH(CH 3 )--CF 3 , --O--CH 2 --C.tbd.CH and the pharmaceutically acceptable salts thereof.
Claim 3
Dependent Claim
26 words
The compounds according to claim 1 wherein R 1 is hydrogen or chlorine, R 2 is --O--CH 2 --CF 3 and the pharmaceutically acceptable salts thereof.
Claim 4
Dependent Claim
15 words
The compound according to claim 2 designated 7-chloro-1-ethyl-1,3,4,9-tetrahydro-8-(2,2,2-trifluoroethoxy)-pyrano[3,4-b]indole-1-acetic acid and the pharmaceutically acceptable salts thereof.
Claim 5
Dependent Claim
14 words
A compound according to claim 2 designated 1-ethyl-1,3,4,9-tetrahydro-8-(2,2,2-trifluoroethoxy)-pyrano[3,4-b]indole-1-acetic and the pharmaceutically acceptable salts thereof.
Claim 6
Dependent Claim
25 words
A pharmaceutical composition comprising a compound of structure (I), or a pharmaceutically acceptable salt thereof, as define in claim 1 and a pharmaceutically acceptable carrier.
Claim 7
Dependent Claim
51 words
A pharmaceutical composition comprising a compound of structure (I), or a pharmaceutically acceptable salt thereof, as defined in claim 1, a nonsteroid anti-inflammatory drug selected from the group consisting of, ibuprofen and aspirin, an opiate analgesic selected from the group consisting of codeine, oxycodone and morphine and a pharmaceutically acceptable carrier.
Claim 8
Dependent Claim
51 words
A method for treating inflammatory conditions and for analgesic purposes in conditions which require relief from pain in a mammal which comprises the administration to said mammal of an effective amount of a compound selected from those of formula (I), or a pharmaceutically acceptable salt thereof, as claimed in claim 1.
Claim 9
Dependent Claim
60 words
A method for treating inflammatory conditions and for analgesic purposes in conditions which require relief from pain in a mammal which comprises the administration to said mammal of an effective amount of a compound selected from those of formula (I), or a pharmaceutically acceptable salt thereof, as claimed in claim 1, in conjunction with nonsteroid anti-inflammatory drugs and opiate analgesics.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1992-03-06 | 1992-09-05 | 1993-03-07 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1996-03-06 | 1996-09-05 | 1997-03-07 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2000-03-06 | 2000-09-05 | 2001-03-07 | $7700.00 | Window Closed / Lapsed |