Patent US4806494A successfully refreshed from Google Patents.
US4806494A
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US
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Monoclonal antibody against ovarian cancer cells (OVB-3)
Assignee: United States Department of Health and Human Services
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Filing: 1986-07-24
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Granted: 1989-02-21
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Expires: 2006-07-24
Abstract
Abstract Monoclonal antibodies are produced which specifically bind to human ovarian cancer cells. These antibodies are conjugated to Pseudomonas exotoxin in order to produce an immunotoxin suitable for the chemotherapeutic treatment of human ovarian cancer.
Inventors
- 👤 Ira Pastan
- 👤 David J. Fitzgerald
- 👤 Mark Willingham
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 14:36
CPC Classifications
C; C07; C07K; C07K16/00; C07K16/18; C07K16/28; C07K16/30; A; A61; A61K; A61K47/00; A61K47/50; A61K47/51; A61K47/68; A61K47/6801; A61K47/6803; A61K47/6811; A61K47/6817; A61K47/6829; A61K47/6835; A61K47/6851; A61K47/6855; A61K38/00
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
24 words
Monoclonal antibody OVB-3 having all the characteristics of that antibody produced by the hydroma ell line which has been assigned ATCC Accession No. HB9147.
Claim 2
Dependent Claim
24 words
Monoclonal antibody OVB-3 having all the characteristics of that antibody produced by the hydroma ell line which has been assigned ATCC Accession No. HB9147.
Claim 3
Dependent Claim
27 words
An immunotoxin conjugate for the chemotherapeutic alleviation of human ovarian cancer comprising a monoclonal antibody OVB-3 which specifically binds to ovarian cancer cells bonded to Pseudomonas exotoxin.
Claim 4
Dependent Claim
27 words
An immunotoxin conjugate for the chemotherapeutic alleviation of human ovarian cancer comprising a monoclonal antibody OVB-3 which specifically binds to ovarian cancer cells bonded to Pseudomonas exotoxin.
Claim 5
Dependent Claim
76 words
An immunotoxin conjugate comprising Pseudomonas exotoxin (PE) bound to a monoclonal antibody which specifically binds to ovarian cancer cells wherein said PE is modified by treatment with 2-iminothiolane followed by treatment with dithiobis(2-nitrobenzoic acid) and wherein said monoclonal antibody is modified by treatment with a reagent selected from the group consisting of 2-imminothiolane and m-maleimidobenzoyl N-hydroxysuccinimide ester under conditions which effect the formation of a disulfide or thioether bond between said PE and said monoclonal antibody.
Claim 6
Dependent Claim
76 words
An immunotoxin conjugate comprising Pseudomonas exotoxin (PE) bound to a monoclonal antibody which specifically binds to ovarian cancer cells wherein said PE is modified by treatment with 2-iminothiolane followed by treatment with dithiobis(2-nitrobenzoic acid) and wherein said monoclonal antibody is modified by treatment with a reagent selected from the group consisting of 2-imminothiolane and m-maleimidobenzoyl N-hydroxysuccinimide ester under conditions which effect the formation of a disulfide or thioether bond between said PE and said monoclonal antibody.
Claim 7
Dependent Claim
16 words
A composition of matter comprising a monoclonal antibody of claim 1 conjugated with a Pseudomonas exotoxin.
Claim 8
Dependent Claim
14 words
A composition of matter comprising an monoclonal antibody of claim 1 in a carrier.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1992-02-21 | 1992-08-22 | 1993-02-21 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1996-02-21 | 1996-08-22 | 1997-02-21 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2000-02-21 | 2000-08-22 | 2001-02-21 | $7700.00 | Window Closed / Lapsed |