US4803066A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Antibacterial and/or antifungal compositions for topical application
Assignee: Smith and Nephew PLC
•
Filing: 1987-03-19
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Granted: 1989-02-07
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Expires: 2007-03-19
Abstract
Abstract Pharmaceutical compositions which are suitable for topical application in the treatment of bacterial and/or fungal infections are described. The compositions comprise a synergistic mixture of a silver compound and an azole derivative together with a pharmaceutically acceptable carrier therefor. The compositions may be applied topically in the treatment of burns ulcers and other skin lesions, general skin infections and also in the treatment of infections of the mucous membranes. Preferred compositions contain silver sulphadiazine and clotrimazole or metronidazole. The compositions may be applied as ointments, gels, pessaries, tablets and the like.
Inventors
- 👤 Linda M. Edwards
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-04 21:42
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/33; A61K31/395; A61K31/41; A61K31/415; A61K33/00; A61K33/24; A61K33/38; A61P; A61P31/00; A61P31/04
Claims Analysis
Total Claims: 28
Claim 1
Independent Claim
46 words
A pharmaceutical composition in topical administration form which comprises a synergistic mixture of an antimicrobial silver compound and an antimicrobial azole compound or a pharmaceutically acceptable acid addition salt thereof in the weight ratio of 10:1 to 1:10; in combination with a topically acceptable carrier therefor.
Claim 2
Dependent Claim
46 words
A pharmaceutical composition in topical administration form which comprises a synergistic mixture of an antimicrobial silver compound and an antimicrobial azole compound or a pharmaceutically acceptable acid addition salt thereof in the weight ratio of 10:1 to 1:10; in combination with a topically acceptable carrier therefor.
Claim 3
Dependent Claim
131 words
A composition according to claim 1 wherein the azole is a compound of the the formula (I) ##STR3## or a pharmaceutically acceptable acid addition salt thereof, wherein Q is CH or N, n is 0 or 1, R 1 is lower alkanyl, lower hydroxy alkyl, phenyl or phenyl loweer alkyl wherein the phenyl groups are unsubstituted or substituted with up to 3 halogen atoms, R 2 is aryl, aryloxy, arylthio, aryl lower alkyloxy or aryl lower alkylthio, wherein aryl is phenyl, thienyl or halothienyl, the phenyl group being unsubstituted or substituted with up to 3 halogen atoms and R 3 is hydrogen, lower alkynyl, lower alkoxycarbonyl or phenyl, the phenyl group being unsubstituted or substituted with up to 3 substituents, each independently selected from the group consisting of halogen and trifluoromethyl.
Claim 4
Dependent Claim
40 words
A composition according to claim 2 in which Q is CH, n is 1, R 1 is mono or dihalophenyl, R 2 is (mono or dihalophenyl) methoxy and R 3 is hydrogen or a pharmaceutically acceptable acid addition salt thereof.
Claim 5
Dependent Claim
16 words
A composition according to claim 3 in which the azole compound is 1-{2-(2,4-dichlorophenyl)-2-[2,4-dichlorophenyl)methoxy]ethyl}-1H-imidazale nitrate micronazole nitrate).
Claim 6
Dependent Claim
16 words
A composition according to claim 3 in which the azole compound is 1-{2-(2,4-dichlorophenyl)-2-[(4-chlorophenymethoxy]ethyl}-1H-imidazole nitrate (econazole nitrate).
Claim 7
Dependent Claim
27 words
A composition according to claim 2 in which Q is CH, n is 0 R 1 is mono- or dihalophenyl, R 2 and R 3 are phenyl.
Claim 8
Dependent Claim
15 words
A composition according to claim 6 in which the azole compound is 1{(2-chlorophenyl)diphenyl methyl}-1H-amidazole (clotrimazole).
Claim 9
Dependent Claim
56 words
A composition according to claim 1 wherein the azole is a compound of the formula (II) ##STR4## or a pharmaceutically acceptable acid addition salt thereof wherein R 4 is hydrogel or lower alkyl, m is 2 to 4 and X is hydrogen or an acyl residue of a monocarboxylic or dicarboxylic aliphotic acid or aromatic acid.
Claim 10
Dependent Claim
14 words
A composition according to claim 8 in which the azole compound is 1-(2-hydroxyethyl)-2-methyl-5-nitroimidazole (metronidazole).
Claim 11
Dependent Claim
39 words
A composition according to claim 1 in which the mixture contains from 0.1 to 10% by weight of the silver compound and from 0.1 to 10% by weight of the azole compound or pharmaceutically acceptable acid addition salt thereof.
Claim 12
Dependent Claim
39 words
A composition according to claim 10 in which the mixture contains from 0.2 to 5% by weight of the silver compound and from 0.2 to 5% by weight of the azole compound or pharmaceutically acceptable acid addition salt thereof.
Claim 13
Dependent Claim
39 words
A composition according to claim 11 in which the mixture contains from 0.5 to 3% by weight of the silver compound and from 0.5 to 3% by weight of the azole compound or pharmaceutically acceptable acid addition salt thereof.
Claim 14
Dependent Claim
15 words
A composition according to claim 1 in which the silver compound is a silver sulphanamide.
Claim 15
Dependent Claim
14 words
A composition according to claim 13 in which the silver compound is silver sulphadiazine.
Claim 16
Dependent Claim
15 words
A composition according to claim 1 which is in the form of a hydrophilic ointment.
Claim 17
Dependent Claim
15 words
A composition according to claim 1 which is in the form of a hydrophobic ointment.
Claim 18
Dependent Claim
14 words
A composition according to claim 1 which is in the form of a tablet.
Claim 19
Dependent Claim
14 words
A composition according to claim 1 which is in the form of a pessary.
Claim 20
Dependent Claim
15 words
A composition according to claim 1 which is in the form of an aqueous gel.
Claim 21
Dependent Claim
14 words
A composition according to claim 1 wherein the weight ratio is 5:1 to 1:5.
Claim 22
Dependent Claim
14 words
A composition according to claim 1 wherein the weight ratio is 2:1 to 1:1.
Claim 23
Dependent Claim
12 words
A composition according to claim 1 wherein the weight ratio is 1:1.
Claim 24
Independent Claim
61 words
A method of treating burns, ulcers or other skin lesions which comprises applying topically thereto a pharmaceutical composition in topical administration form which comprises a synergistic mixture of an antimicrobial silver compound and an antimicrobial azole compound or a pharmaceutically acceptable acid addition salt thereof in the weight ratio of 10:1 to 1:10 in combination with a topically acceptable carrier therefor.
Claim 25
Independent Claim
61 words
A method of treating burns, ulcers or other skin lesions which comprises applying topically thereto a pharmaceutical composition in topical administration form which comprises a synergistic mixture of an antimicrobial silver compound and an antimicrobial azole compound or a pharmaceutically acceptable acid addition salt thereof in the weight ratio of 10:1 to 1:10 in combination with a topically acceptable carrier therefor.
Claim 26
Dependent Claim
14 words
A method according to claim 23 wherein the weight ratio is 5:1 to 1:5.
Claim 27
Dependent Claim
14 words
A method according to claim 23 wherein the weight ratio is 2:1 to 1:2.
Claim 28
Dependent Claim
12 words
A method according to claim 23 wherein the weight ratio is 1:1.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1992-02-07 | 1992-08-08 | 1993-02-07 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1996-02-07 | 1996-08-08 | 1997-02-07 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2000-02-07 | 2000-08-08 | 2001-02-07 | $7700.00 | Window Closed / Lapsed |