US4438258A
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Hydrogels
Assignee: BTG International Ltd
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Filing: 1982-06-14
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Granted: 1984-03-20
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Expires: 2002-06-14
Abstract
Abstract A hydrogel which comprises polymerized moieties derivable from (i) at least one polymerizable cyclic (thio)ether and (ii) at least one hydrophilic homo- or copolymer.
Inventors
- 👤 Neil B. Graham
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 02:39
CPC Classifications
C; C08; C08G; C08G75/00; C08G75/02; C08G75/06; A; A01; A01N; A01N25/00; A01N25/08; A01N25/10; A61; A61K; A61K9/00; A61K9/20; A61K9/2004; A61K9/2022; A61K9/2031; A61L; A61L15/00; A61L15/16; A61L15/22; A61L15/42; A61L15/60; C08G65/00; C08G65/02; C08G65/04; C08G65/06; C08G65/16
Claims Analysis
Total Claims: 34
Claim 1
Independent Claim
145 words
A hydrogel, which comprises: polymerized moieties derivable from (i) at least one unsaturated cyclic(thio) ether of the formula: ##STR16## wherein R 1 , R 2 and R 4 , which may be the same or different, each represent hydrogen or a substituted or unsubstituted hydrocarbyl or hydrocarbyloxy group; R 3 represents a substituted or unsubstituted methylene, ethylene, or 1,3-propylene group; R 5 represents a monovalent polymerizable group; Q represents an oxygen or sulfur atom; and X represents: ##STR17## wherein Y represents an oxygen atom or an --NR 6 -- group wherein R 6 represents any of the values which R 1 may assume; a is 0 or 1; b is 0 or 1; c is 1 or 2; d is 0 or 1; with the proviso that at least one of b or d is 1, and (ii) at least one hydrophilic homo- or copolymer.
Claim 2
Dependent Claim
145 words
A hydrogel, which comprises: polymerized moieties derivable from (i) at least one unsaturated cyclic(thio) ether of the formula: ##STR16## wherein R 1 , R 2 and R 4 , which may be the same or different, each represent hydrogen or a substituted or unsubstituted hydrocarbyl or hydrocarbyloxy group; R 3 represents a substituted or unsubstituted methylene, ethylene, or 1,3-propylene group; R 5 represents a monovalent polymerizable group; Q represents an oxygen or sulfur atom; and X represents: ##STR17## wherein Y represents an oxygen atom or an --NR 6 -- group wherein R 6 represents any of the values which R 1 may assume; a is 0 or 1; b is 0 or 1; c is 1 or 2; d is 0 or 1; with the proviso that at least one of b or d is 1, and (ii) at least one hydrophilic homo- or copolymer.
Claim 3
Dependent Claim
12 words
The hydrogel according to claim 1 which is hydrolysable in aqueous media.
Claim 4
Dependent Claim
16 words
The hydrogel according to claim 1 or 2 wherein a hydrolysable function is contained in (i).
Claim 5
Dependent Claim
15 words
The hydrogel according to any preceding claim wherein a hydrolysable function is contained in (ii).
Claim 6
Dependent Claim
22 words
The hydrogel according to any preceding claim wherein the hydrogel comprises a hydrolysable carboxylic ester, carbonate ester, amide, urethane or glycoside function.
Claim 7
Dependent Claim
14 words
The hydrogel according to claim 1 wherein X represents --COO-- or --CH 2 OCO--.
Claim 8
Dependent Claim
14 words
The hydrogel according to claim 6 wherein the cyclic ether has the formula: ##STR18##
Claim 9
Dependent Claim
50 words
The hydrogel according to claim 7 wherein the cyclic ether has the formula: ##STR19## in which: R 1 ', R 2 ', and R 4 ', which may be the same or different, represent any of the values which R 1 , R 2 and R 4 respectively may assume.
Claim 10
Dependent Claim
13 words
The hydrogel according to claim 8 wherein the cyclic ether is acrolein tetramer.
Claim 11
Dependent Claim
14 words
The hydrogel according to any preceding claim wherein the cyclic compound is an ether.
Claim 12
Dependent Claim
90 words
The hydrogel according to any preceding claim wherein the hydrophilic homo- or copolymer (ii) comprises residues derivable from at least one of the following monomer classes: (a) (meth)acrylic acid, (meth)acrylamide or an unsubstituted or hydroxy-substituted ethyl or propyl (meth)acrylate, or a poly(oxyethylene) ester of (meth)acrylic acid; (b) a substituted or unsubstituted cyclic mono- or polyether having from 3 to 6 ring atoms or a cyclic imine having 3 ring atoms; or (c) a substituted or unsubstituted vinyl alcohol, aldehyde, ether acetal, ketone, ester or substituted or unsubstituted N-vinyl hetereocyclic compound.
Claim 13
Dependent Claim
19 words
The hydrogel according to any preceding claim wherein the hydrophilic homo- or copolymer (ii) comprises polymerised alkylene oxide residues.
Claim 14
Dependent Claim
13 words
The hydrogel according to claim 12 wherein the alkylene oxide comprises ethylene oxide.
Claim 15
Dependent Claim
21 words
The hydrogel according to claim 11, 12 or 13 wherein the hydrophilic homo- or copolymer is a homo- or copoly(alkylene oxide).
Claim 16
Dependent Claim
18 words
The hydrogel according to claim 9 wherein the hydrophilic homo- or copolymer is a homo- or copoly(ethylene oxide).
Claim 17
Dependent Claim
31 words
The hydrogel according to claim 13 or 15 wherein the homo- or copoly(alkylene oxide) comprises polyethylene oxide residues having a ratio of number average molecular weight to functionality greater than 1000.
Claim 18
Dependent Claim
22 words
The hydrogel according to claim 16 wherein the residues have a ratio of number average molecular weight to functionality greater than 1,500.
Claim 19
Dependent Claim
22 words
The hydrogel according to claim 17 wherein the residues have a ratio of number average molecular weight to functionality greater than 2,000.
Claim 20
Dependent Claim
23 words
The hydrogel according to any preceding claim which is a crystalline hydrogel in the dry form and exhibits syneresis in the wet form.
Claim 21
Dependent Claim
34 words
The hydrogel according to any of claims 14 to 19 wherein the polyethylene oxide is the reaction product of (a) ethylene oxide with (b) an aliphatic or aromatic hydroxyl, carboxyl, amino or mercapto compound.
Claim 22
Dependent Claim
15 words
The hydrogel according to claim 20 wherein (b) comprises a di- or tri-hydroxyl-substituted aliphatic compound.
Claim 23
Dependent Claim
18 words
The hydrogel according to any preceding claim wherein (i) and (ii) are chemically cross-linked to form the hydrogel.
Claim 24
Dependent Claim
25 words
The hydrogel according to claim 22 wherein chemical cross-linking is effected by incorporating into the hydrogel a compound with more than two active hydrogen atoms.
Claim 25
Dependent Claim
15 words
The hydrogel according to claim 23 wherein the compound contains more than two hydroxyl groups.
Claim 26
Dependent Claim
25 words
The hydrogel according to claim 22 wherein chemical cross-linking is effected by incorporating into the hydrogel a compound comprising more than two cyclic (thio)ether groups.
Claim 27
Dependent Claim
21 words
The hydrogel according to claim 22 wherein chemical cross-linking is effected by incorporating into the hydrogel a stoichiometric excess of (i).
Claim 28
Dependent Claim
19 words
The hydrogel according to any preceding claim which has a glass transition temperature from -120° C. to +15° C.
Claim 29
Dependent Claim
19 words
The hydrogel according to any preceding claim which has a crystallite melting temperature from +10° C. to +60° C.
Claim 30
Dependent Claim
13 words
The hydrogel according to any preceding claim for use in prophylaxis or therapy.
Claim 31
Dependent Claim
12 words
The hydrogel according to claim 29 for use as a wound dressing.
Claim 32
Dependent Claim
10 words
The hydrogel according to any preceding claim which is particulate.
Claim 33
Dependent Claim
21 words
A hydrogel, which comprises: a polymerizate derived from the reaction of polyethylene oxide with an acrolein tetramer of the formula: ##STR20##
Claim 34
Dependent Claim
21 words
A hydrogel, which comprises: a polymerizate derived from the reaction of polyethylene oxide with an acrolein tetramer of the formula: ##STR20##
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1987-03-20 | 1987-09-19 | 1988-03-20 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1991-03-20 | 1991-09-19 | 1992-03-20 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1995-03-20 | 1995-09-19 | 1996-03-20 | $7700.00 | Window Closed / Lapsed |