US4798904A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Certain [(lower alkanoyl-thio)methyl-1-oxo-3-phenyl propyl amino]benzene lower alkanoic acid or ester derivatives which inhibit enkephalinase
Assignee: ER Squibb and Sons LLC
•
Filing: 1987-11-13
•
Granted: 1989-01-17
•
Expires: 2007-11-13
Abstract
Abstract Acylmercaptoalkanoyl compounds of the formula ##STR1## wherein n is an integer from one to fifteen possess enkephalinase inhibition activity and are useful as analgesic agents.
Inventors
- 👤 Norma G. Delaney
- 👤 Eric M. Gordon
- 👤 Miguel A. Ondetti
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-06 06:16
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/16
Claims Analysis
Total Claims: 18
Claim 1
Independent Claim
110 words
A compound of the formula: ##STR91## including a pharmaceutically acceptable salt thereof wherein: ##STR92## R 3 is hydrogen, lower alkyl, ##STR93## R 4 is --OH or --OCH 3 ; n is an integer from 1 to 15; R 5 is lower alkyl, ##STR94## m is zero or an integer from 1 to 4; R 6 is lower alkyl of 1 to 4 carbons, lower alkoxy of 1 to 4 carbons, lower alkylthio of 1 to 4 carbons, hydroxy, Cl, Br, F or trifluoromethyl; and r is an integer from 1 to 3 provided that r is more than one only if R 6 is hydroxy, methyl, methoxy, Cl, or F.
Claim 2
Dependent Claim
110 words
A compound of the formula: ##STR91## including a pharmaceutically acceptable salt thereof wherein: ##STR92## R 3 is hydrogen, lower alkyl, ##STR93## R 4 is --OH or --OCH 3 ; n is an integer from 1 to 15; R 5 is lower alkyl, ##STR94## m is zero or an integer from 1 to 4; R 6 is lower alkyl of 1 to 4 carbons, lower alkoxy of 1 to 4 carbons, lower alkylthio of 1 to 4 carbons, hydroxy, Cl, Br, F or trifluoromethyl; and r is an integer from 1 to 3 provided that r is more than one only if R 6 is hydroxy, methyl, methoxy, Cl, or F.
Claim 3
Dependent Claim
52 words
A compound of claim 1 wherein: R 1 is ##STR95## R 2 is ##STR96## R 3 is hydrogen, straight or branched chain alkyl of 1 to 4 carbons, ##STR97## m is one or two; R 6 is methyl, methoxy, Cl, F, or hydroxy; and n is an integer from 1 to 9.
Claim 4
Dependent Claim
19 words
A compound of claim 2 wherein: R 2 is benzyl; and n is an integer from 3 to 6.
Claim 5
Dependent Claim
10 words
A compound of claim 2 wherein R 1 is ##STR98##
Claim 6
Dependent Claim
10 words
A compound of claim 3 wherein R 1 is ##STR99##
Claim 7
Dependent Claim
10 words
A compound of claim 2 wherein R 1 is ##STR100##
Claim 8
Dependent Claim
10 words
The compound of claim 3 wherein R 1 is ##STR101##
Claim 9
Dependent Claim
9 words
A compound of claim 5 wherein n is 3.
Claim 10
Dependent Claim
17 words
The compound of claim 8 wherein R 3 is hydrogen; and R 4 is --OCH 3 .
Claim 11
Dependent Claim
9 words
A compound of claim 5 wherein n is 4.
Claim 12
Dependent Claim
9 words
A compound of claim 5 wherein n is 5.
Claim 13
Dependent Claim
17 words
The compound of claim 11 wherein R 3 is hydrogen; and R 4 is --OCH 3 .
Claim 14
Dependent Claim
9 words
A compound of claim 5 wherein n is 6.
Claim 15
Dependent Claim
9 words
A compound of claim 7 wherein n is 3.
Claim 16
Dependent Claim
9 words
A compound of claim 7 wherein n is 4.
Claim 17
Dependent Claim
9 words
A compound of claim 7 wherein n is 5.
Claim 18
Dependent Claim
9 words
A compound of claim 7 wherein n is 6.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1992-01-17 | 1992-07-18 | 1993-01-17 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1996-01-17 | 1996-07-18 | 1997-01-17 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2000-01-17 | 2000-07-18 | 2001-01-17 | $7700.00 | Window Closed / Lapsed |